Patents by Inventor Matthew R. Banghart

Matthew R. Banghart has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Photocleavable Chemical Inducers of Dimerization (CID) and Methods of Use
    Publication number: 20190284164
    Abstract: The instant invention provides photolysable compounds, and their use in reversible chemical induced dimerization and light-induced regulation of proteins.
    Type: Application
    Filed: August 20, 2018
    Publication date: September 19, 2019
    Applicants: Children's Medical Center Corporation, President and Fellows of Harvard College
    Inventors: Thomas L. Schwarz, Matthew R. Banghart, Amos Gutnick
  • Photocleavable chemical inducers of dimerization (CID) and methods of use
    Patent number: 10053445
    Abstract: The instant invention provides photolysable compounds, and their use in reversible chemical induced dimerization and light-induced regulation of proteins.
    Type: Grant
    Filed: October 24, 2014
    Date of Patent: August 21, 2018
    Assignees: Children's Medical Center Corporation, President and Fellows of Harvard College
    Inventors: Thomas L. Schwarz, Matthew R. Banghart, Amos Gutnick
  • Photoreactive synthetic regulator of protein function and methods of use thereof
    Patent number: 9688617
    Abstract: The present disclosure provides a photoreactive synthetic regulator of protein function. The present disclosure further provides a light-regulated polypeptide that includes a subject synthetic regulator. Also provided are cells and membranes comprising a subject light-regulated polypeptide. The present disclosure further provides methods of modulating protein function, involving use of light.
    Type: Grant
    Filed: April 19, 2016
    Date of Patent: June 27, 2017
    Assignee: The Regents of the University of California
    Inventors: Dirk Trauner, Ehud Y. Isacoff, Richard H. Kramer, Matthew R. Banghart, Doris L. Fortin, Alexandre Mourot
  • Photoreactive regulator of protein function and methods of use thereof
    Patent number: 9629911
    Abstract: The present invention provides a synthetic regulator of protein function, which regulator is a light-sensitive regulator. The present invention further provides a light-regulated polypeptide that includes a subject synthetic regulator. Also provided are cells and membranes comprising a subject light-regulated polypeptide. The present invention further provides methods of modulating protein function, involving use of light. The present invention further provides methods of identifying agents that modulate protein function.
    Type: Grant
    Filed: January 8, 2015
    Date of Patent: April 25, 2017
    Assignee: The Regents of the University of California
    Inventors: Ehud Y. Isacoff, Richard H. Kramer, Dirk Trauner, Matthew R. Banghart, Matthew Volgraf, Pablo Ignacio Gorostiza Langa, Katharine Borges
  • PHOTOCLEAVABLE CHEMICAL INDUCERS OF DIMERIZATION (CID) AND METHODS OF USE
    Publication number: 20160272618
    Abstract: The instant invention provides photolysable compounds, and their use in reversible chemical induced dimerization and light-induced regulation of proteins.
    Type: Application
    Filed: October 24, 2014
    Publication date: September 22, 2016
    Applicants: CHILDREN'S MEDICAL CENTER CORPORATION, PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Thomas L. Schwarz, Matthew R. Banghart, Amos Gutnick
  • PHOTOREACTIVE SYNTHETIC REGULATOR OF PROTEIN FUNCTION AND METHODS OF USE THEREOF
    Publication number: 20160229794
    Abstract: The present disclosure provides a photoreactive synthetic regulator of protein function. The present disclosure further provides a light-regulated polypeptide that includes a subject synthetic regulator. Also provided are cells and membranes comprising a subject light-regulated polypeptide. The present disclosure further provides methods of modulating protein function, involving use of light.
    Type: Application
    Filed: April 19, 2016
    Publication date: August 11, 2016
    Inventors: Dirk Trauner, Ehud Y. Isacoff, Richard H. Kramer, Matthew R. Banghart, Doris L. Fortin, Alexandre Mourot
  • Photoreactive synthetic regulator of protein function and methods of use thereof
    Patent number: 9334231
    Abstract: The present disclosure provides a photoreactive synthetic regulator of protein function. The present disclosure further provides a light-regulated polypeptide that includes a subject synthetic regulator. Also provided are cells and membranes comprising a subject light-regulated polypeptide. The present disclosure further provides methods of modulating protein function, involving use of light.
    Type: Grant
    Filed: February 19, 2015
    Date of Patent: May 10, 2016
    Assignee: The Regents of the University of California
    Inventors: Dirk Trauner, Ehud Y. Isacoff, Richard H. Kramer, Matthew R. Banghart, Doris L. Fortin, Alexandre Mourot
  • PHOTOREACTIVE REGULATOR OF PROTEIN FUNCTION AND METHODS OF USE THEREOF
    Publication number: 20150224193
    Abstract: The present invention provides a synthetic regulator of protein function, which regulator is a light-sensitive regulator. The present invention further provides a light-regulated polypeptide that includes a subject synthetic regulator. Also provided are cells and membranes comprising a subject light-regulated polypeptide. The present invention further provides methods of modulating protein function, involving use of light. The present invention further provides methods of identifying agents that modulate protein function.
    Type: Application
    Filed: January 8, 2015
    Publication date: August 13, 2015
    Inventors: Ehud Y. Isacoff, Richard H. Kramer, Dirk Trauner, Matthew R. Banghart, Matthew Volgraf, Pablo Ignacio Gorostiza Langa, Katharine Borges
  • Photoreactive regulator of protein function and methods of use thereof
    Patent number: 9097707
    Abstract: The present invention provides a synthetic regulator of protein function, which regulator is a light-sensitive regulator. The present invention further provides a light-regulated polypeptide that includes a subject synthetic regulator. Also provided are cells and membranes comprising a subject light-regulated polypeptide. The present invention further provides methods of modulating protein function, involving use of light. The present invention further provides methods of identifying agents that modulate protein function.
    Type: Grant
    Filed: November 8, 2012
    Date of Patent: August 4, 2015
    Assignee: The Regents of the University of California
    Inventors: Ehud Y. Isacoff, Richard H. Kramer, Dirk Trauner, Matthew R. Banghart, Matthew Volgraf, Pablo Ignacio Gorostiza Langa, Katharine Borges
  • PHOTOREACTIVE SYNTHETIC REGULATOR OF PROTEIN FUNCTION AND METHODS OF USE THEREOF
    Publication number: 20150158811
    Abstract: The present disclosure provides a photoreactive synthetic regulator of protein function. The present disclosure further provides a light-regulated polypeptide that includes a subject synthetic regulator. Also provided are cells and membranes comprising a subject light-regulated polypeptide. The present disclosure further provides methods of modulating protein function, involving use of light.
    Type: Application
    Filed: February 19, 2015
    Publication date: June 11, 2015
    Inventors: Dirk Trauner, Ehud Y. Isacoff, Richard H. Kramer, Matthew R. Banghart, Doris L. Fortin, Alexandre Mourot
  • Photoreactive synthetic regulator of protein function and methods of use thereof
    Patent number: 8993736
    Abstract: The present disclosure provides a photoreactive synthetic regulator of protein function. The present disclosure further provides a light-regulated polypeptide that includes a subject synthetic regulator. Also provided are cells and membranes comprising a subject light-regulated polypeptide. The present disclosure further provides methods of modulating protein function, involving use of light.
    Type: Grant
    Filed: October 29, 2009
    Date of Patent: March 31, 2015
    Assignee: The Regents of the University of California
    Inventors: Dirk Trauner, Ehud Y. Isacoff, Richard H. Kramer, Matthew R. Banghart, Doris L. Fortin, Alexandre Mourot
  • Photoreactive regulator of protein function and methods of use thereof
    Patent number: 8309350
    Abstract: The present invention provides a synthetic regulator of protein function, which regulator is a light-sensitive regulator. The present invention further provides a light-regulated polypeptide that includes a subject synthetic regulator. Also provided are cells and membranes comprising a subject light-regulated polypeptide. The present invention further provides methods of modulating protein function, involving use of light. The present invention further provides methods of identifying agents that modulate protein function.
    Type: Grant
    Filed: February 1, 2012
    Date of Patent: November 13, 2012
    Assignee: The Regents of the University of California
    Inventors: Ehud Y. Isacoff, Richard H. Kramer, Dirk Trauner, Matthew R. Banghart, Matthew Volgraf, Pablo Ignacio Gorostiza Langa, Katharine Borges
  • Photoreactive Regulator of Protein Function and Methods of Use Thereof
    Publication number: 20120190094
    Abstract: The present invention provides a synthetic regulator of protein function, which regulator is a light-sensitive regulator. The present invention further provides a light-regulated polypeptide that includes a subject synthetic regulator. Also provided are cells and membranes comprising a subject light-regulated polypeptide. The present invention further provides methods of modulating protein function, involving use of light. The present invention further provides methods of identifying agents that modulate protein function.
    Type: Application
    Filed: February 1, 2012
    Publication date: July 26, 2012
    Inventors: EHUD Y. ISACOFF, Richard H. Kramer, Dirk Trauner, Matthew R. Banghart, Matthew Volgraf, Pablo Ignacio Gorostiza Langa, Katharine Borges
  • Caged Neuropeptides: modulation and measurement of synapse and signaling activity; and methods for drug evaluation, pharmaceuticals preparation and treatment
    Publication number: 20120136416
    Abstract: A neuropeptide is caged and delivered to a synaptic site, then photolytically activated to enable precise temporal and spatial temporal investigation of localized signaling activity or synaptic responses. Caged molecules, delivery and activation systems clarify the kinetics and activity of neuropeptide-mediated signaling to identify agonists and permit focused drug evaluation for specific diseases and conditions. The caged peptides may also provide light-mediated treatment therapies for localized relief of pain or nerve-related conditions, and serve as a screening or measurement tool for potential agonists and antagonists. A kit includes the caged molecule and may further include a reporter for indicating response to the activated neuropeptide.
    Type: Application
    Filed: November 18, 2011
    Publication date: May 31, 2012
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Bernardo L. Sabatini, Matthew R. Banghart
  • Photoreactive Synthetic Regulator of Protein Function and Methods of Use Thereof
    Publication number: 20110207213
    Abstract: The present disclosure provides a photoreactive synthetic regulator of protein function. The present disclosure further provides a light-regulated polypeptide that includes a subject synthetic regulator. Also provided are cells and membranes comprising a subject light-regulated polypeptide. The present disclosure further provides methods of modulating protein function, involving use of light.
    Type: Application
    Filed: October 29, 2009
    Publication date: August 25, 2011
    Inventors: Dirk Trauner, Ehud Y. Isacoff, Richard H. Kramer, Matthew R. Banghart, Doris L. Fortin, Alexandre Mourot