Patents by Inventor Matthew R. Dreher

Matthew R. Dreher has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11957755
    Abstract: Radiopaque hydrogels, in particular radiopaque hydrogel microspheres, comprising a polymer having 1,2-dil or 1,3-diol groups acetalized with radiopaque species.
    Type: Grant
    Filed: May 25, 2021
    Date of Patent: April 16, 2024
    Assignee: Boston Scientific Medical Device Limited
    Inventors: Stephane Hohn, Andrew Lennard Lewis, Sean Leo Willis, Matthew R. Dreher, Koorosh Ashrafi, Yiqing Tang
  • Patent number: 11672876
    Abstract: This invention concerns imageable, radiopaque embolic beads, which are particularly useful for monitoring embolization procedures. The beads comprise iodine containing compounds which are covalently incorporated into the polymer network of a preformed hydrogel bead. The beads are prepared by activating pre-formed hydrogel beads towards nucleophilic attack and then covalently attaching iodinated compounds into the polymer network. The radiopaque beads may be loaded with chemotherapeutic agents and used in methods of embolizing hyperplastic tissue or solid tumors.
    Type: Grant
    Filed: January 22, 2020
    Date of Patent: June 13, 2023
    Assignees: BIOCOMPATIBLES UK LIMITED, THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
    Inventors: Matthew R. Dreher, Bradford J. Wood, Ayele H. Negussie, Andrew Lennard Lewis, Yiqing Tang
  • Publication number: 20220008339
    Abstract: This present disclosure relates to compositions and methods useful in therapeutic embolisation and particularly in methods for bariatric arterial embolisation (BAE).
    Type: Application
    Filed: September 24, 2021
    Publication date: January 13, 2022
    Inventors: Matthew R. Dreher, Clifford Weiss
  • Publication number: 20210275674
    Abstract: Radiopaque hydrogels, in particular radiopaque hydrogel microspheres, comprising a polymer having 1,2-dil or 1,3-diol groups acetalized with radiopaque species.
    Type: Application
    Filed: May 25, 2021
    Publication date: September 9, 2021
    Inventors: Stephane HOHN, Andrew Lennard Lewis, Sean Leo Willis, Matthew R. Dreher, Koorosh Ashrafi, Yiqing Tang
  • Publication number: 20210236660
    Abstract: This invention relates to imageable polymers, particularly those comprising poly vinylalcohol and to methods for making them as well as to embolic microspheres comprising the polymers. The microspheres are imageable during embolization procedures and can be loaded with drugs or other therapeutic agents to provide an imageable drug delivery system.
    Type: Application
    Filed: January 15, 2021
    Publication date: August 5, 2021
    Inventors: Stephane HOHN, Andrew Lennard LEWIS, Sean Leo WILLIS, Matthew R. DREHER, Koorosh ASHRAFI, Yiqing TANG
  • Patent number: 11040104
    Abstract: Radiopaque hydrogels, in particular radiopaque hydrogel microspheres, comprising a polymer having 1,2-dil or 1,3-diol groups acetalized with radiopaque species.
    Type: Grant
    Filed: January 3, 2020
    Date of Patent: June 22, 2021
    Assignee: BIOCOMPATIBLES UK LTD.
    Inventors: Stephane Hohn, Andrew Lennard Lewis, Sean Leo Willis, Matthew R. Dreher, Koorosh Ashrafi, Yiqing Tang
  • Patent number: 10925979
    Abstract: This invention relates to imageable polymers, particularly those comprising poly vinylalcohol and to methods for making them as well as to embolic microspheres comprising the polymers. The microspheres are imageable during embolization procedures and can be loaded with drugs or other therapeutic agents to provide an imageable drug delivery system.
    Type: Grant
    Filed: January 3, 2020
    Date of Patent: February 23, 2021
    Assignee: BIOCOMPATIBLES UK LTD.
    Inventors: Stephane Hohn, Andrew Lennard Lewis, Sean Leo Willis, Matthew R. Dreher, Koorosh Ashrafi, Yiqing Tang
  • Publication number: 20200297635
    Abstract: This present disclosure relates to compositions and methods useful in therapeutic embolisation and particularly in methods for bariatric arterial embolisation (BAE).
    Type: Application
    Filed: March 23, 2020
    Publication date: September 24, 2020
    Inventors: Matthew R. Dreher, Clifford Weiss
  • Publication number: 20200289680
    Abstract: A method of treating CNS tumors such as gliomas is provided comprising delivering a ?-emitting radionuclide containing composition to the tumor via the cerebral vasculature.
    Type: Application
    Filed: March 11, 2020
    Publication date: September 17, 2020
    Inventors: Matthew R. Dreher, Alexander Pasciak, Clifford Weiss
  • Publication number: 20200254099
    Abstract: Radiopaque hydrogels, in particular radiopaque hydrogel microspheres, comprising a polymer having 1,2-dil or 1,3-diol groups acetalized with radiopaque species.
    Type: Application
    Filed: January 3, 2020
    Publication date: August 13, 2020
    Inventors: Stephane HOHN, Andrew Lennard Lewis, Sean Leo Willis, Matthew R. Dreher, Koorosh Ashrafi, Yiqing Tang
  • Publication number: 20200254117
    Abstract: This invention relates to imageable polymers, particularly those comprising poly vinylalcohol and to methods for making them as well as to embolic microspheres comprising the polymers. The microspheres are imageable during embolization procedures and can be loaded with drugs or other therapeutic agents to provide an imageable drug delivery system.
    Type: Application
    Filed: January 3, 2020
    Publication date: August 13, 2020
    Inventors: Stephane HOHN, Andrew Lennard LEWIS, Sean Leo WILLIS, Matthew R. DREHER, Koorosh ASHRAFI, Yiqing TANG
  • Publication number: 20200155711
    Abstract: This invention concerns imageable, radiopaque embolic beads, which are particularly useful for monitoring embolization procedures. The beads comprise iodine containing compounds which are covalently incorporated into the polymer network of a preformed hydrogel bead. The beads are prepared by activating pre-formed hydrogel beads towards nucleophilic attack and then covalently attaching iodinated compounds into the polymer network. The radiopaque beads may be loaded with chemotherapeutic agents and used in methods of embolizing hyperplastic tissue or solid tumors.
    Type: Application
    Filed: January 22, 2020
    Publication date: May 21, 2020
    Inventors: Matthew R. DREHER, Bradford J. WOOD, Ayele H. NEGUSSIE, Andrew Lennard LEWIS, Yiqing TANG
  • Patent number: 10568967
    Abstract: Radiopaque hydrogels, in particular radiopaque hydrogel microspheres, comprising a polymer having 1,2-diol or 1,3-diol groups acetalised with radiopaque species.
    Type: Grant
    Filed: January 9, 2019
    Date of Patent: February 25, 2020
    Assignee: Biocompatibles UK Ltd.
    Inventors: Stéphane Hohn, Andrew Lennard Lewis, Sean Leo Willis, Matthew R. Dreher, Koorosh Ashrafi, Yiqing Tang
  • Patent number: 10556022
    Abstract: This invention relates to imageable polymers, particularly those comprising poly vinylalcohol and to methods for making them as well as to embolic microspheres comprising the polymers. The microspheres are imageable during embolization procedures and can be loaded with drugs or other therapeutic agents to provide an imageable drug delivery system.
    Type: Grant
    Filed: September 5, 2018
    Date of Patent: February 11, 2020
    Assignee: Biocompatibles UK Ltd.
    Inventors: Stéphane Hohn, Andrew Lennard Lewis, Sean Leo Willis, Matthew R. Dreher, Koorosh Ashrafi, Yiqing Tang
  • Publication number: 20190328908
    Abstract: This invention concerns imageable, radiopaque embolic beads, which are particularly useful for monitoring embolization procedures. The beads comprise iodine containing compounds which are covalently incorporated into the polymer network of a preformed hydrogel bead. The beads are prepared by activating pre-formed hydrogel beads towards nucleophilic attack and then covalently attaching iodinated compounds into the polymer network. The radiopaque beads may be loaded with chemotherapeutic agents and used in methods of embolizing hyperplastic tissue or solid tumors.
    Type: Application
    Filed: April 11, 2019
    Publication date: October 31, 2019
    Inventors: Matthew R. DREHER, Bradford J. WOOD, Ayele H. NEGUSSIE, Andrew Lennard LEWIS, Yiqing TANG
  • Patent number: 10406257
    Abstract: Pharmaceutical compositions comprising embolic particles, that optionally comprise pharmaceutical actives, in oil or emulsion formulations that are useful in therapeutic embolization procedures, particularly for the treatment of vascularised neoplasias, such as liver carcinomas.
    Type: Grant
    Filed: September 16, 2014
    Date of Patent: September 10, 2019
    Assignee: BIOCOMPATIBLES UK LTD.
    Inventors: Matthew R. Dreher, Andrew Lennard Lewis
  • Patent number: 10350295
    Abstract: Radiopaque hydrogels, in particular radiopaque hydrogel microspheres, comprising a polymer having 1,2-diol or 1,3-diol groups acetalized with radiopaque species.
    Type: Grant
    Filed: September 5, 2014
    Date of Patent: July 16, 2019
    Assignee: BIOCOMPATIBLES UK LTD.
    Inventors: Stéphane Hohn, Andrew Lennard Lewis, Sean Leo Willis, Matthew R. Dreher, Koorosh Ashrafi, Yiqing Tang
  • Patent number: 10307493
    Abstract: This invention concerns imageable, radiopaque embolic beads, which are particularly useful for monitoring embolization procedures. The beads comprise iodine containing compounds which are covalently incorporated into the polymer network of a preformed hydrogel bead. The beads are prepared by activating pre-formed hydrogel beads towards nucleophilic attack and then covalently attaching iodinated compounds into the polymer network. The radiopaque beads may be loaded with chemotherapeutic agents and used in methods of embolizing hyperplastic tissue or solid tumors.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: June 4, 2019
    Assignees: Biocompatible UK Limited, National Institutes of Health
    Inventors: Matthew R. Dreher, Bradford J. Wood, Ayele H. Negussie, Andrew Leonard Lewis, Yiqing Tang
  • Publication number: 20190142946
    Abstract: Radiopaque hydrogels, in particular radiopaque hydrogel microspheres comprising a polymer having 1,2-diol or 1,3-diol groups acetalised with radiopaque species.
    Type: Application
    Filed: January 9, 2019
    Publication date: May 16, 2019
    Inventors: Stephane HOHN, Andrew Lennard Lewis, Sean Leo Willis, Matthew R. Dreher, Koorosh Ashrafi, Yiqing Tang
  • Publication number: 20190111159
    Abstract: This invention relates to imageable polymers, particularly those comprising poly vinylalcohol and to methods for making them as well as to embolic microspheres comprising the polymers.
    Type: Application
    Filed: September 5, 2018
    Publication date: April 18, 2019
    Inventors: Stéphane HOHN, Andrew Lennard LEWIS, Sean Leo WILLIS, Matthew R. DREHER, Koorosh ASHRAFI, Yiqing TANG