Patents by Inventor Matthew R. LEVENGOOD

Matthew R. LEVENGOOD has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MULTI-DRUG ANTIBODY DRUG CONJUGATES
    Publication number: 20240033372
    Abstract: The present disclosure provides, inter alia, multi-drug Antibody Drug Conjugates (MD-ADCs) and Linking Assembly (LA) Units that are constructed in a site-specific matter via “orthogonal” deprotection and drug loading. Also provided are, Protected Linking Assembly Units, which allow for ‘orthogonal’ deprotection and construction of MD-ADCs and LA Units of the present disclosure.
    Type: Application
    Filed: November 10, 2022
    Publication date: February 1, 2024
    Inventor: Matthew R. LEVENGOOD
  • Multi-drug antibody drug conjugates
    Patent number: 11541128
    Abstract: The present disclosure provides, inter alia, multi-drug Antibody Drug Conjugates (MD-ADCs) and Linking Assembly (LA) Units, that are constructed in a site-specific matter via ‘orthogonal’ deprotection and drug loading. Also provided are, Protected Linking Assembly Units, which allow for ‘orthogonal’ deprotection and construction of MD-ADCs and LA Units of the present disclosure.
    Type: Grant
    Filed: December 14, 2017
    Date of Patent: January 3, 2023
    Assignee: Seagen Inc.
    Inventor: Matthew R. Levengood
  • Bivalent antibodies masked by coiled coils
    Patent number: 11230610
    Abstract: The invention provides bivalent antibodies including two light and heavy chain pairs. The N-termini of one or both light and heavy chain pairs are linked via linkers comprising a protease cleavage site to coiled-coil forming peptides that associate to form a coiled coil reducing binding affinity of at least one light-heavy chain pair to a target.
    Type: Grant
    Filed: December 8, 2017
    Date of Patent: January 25, 2022
    Assignee: SEAGEN INC.
    Inventors: Vivian Trang, Matthew R. Levengood, Peter Senter
  • MULTI-DRUG ANTIBODY DRUG CONJUGATES
    Publication number: 20200129639
    Abstract: The present disclosure provides, inter alia, multi-drug Antibody Drug Conjugates (MD-ADCs) and Linking Assembly (LA) Units, that are constructed in a site-specific matter via ‘orthogonal’ deprotection and drug loading. Also provided are, Protected Linking Assembly Units, which allow for ‘orthogonal’ deprotection and construction of MD-ADCs and LA Units of the present disclosure.
    Type: Application
    Filed: December 14, 2017
    Publication date: April 30, 2020
    Inventor: Matthew R. LEVENGOOD
  • BIVALENT ANTIBODIES MASKED BY COILED COILS
    Publication number: 20190352428
    Abstract: The invention provides bivalent antibodies including two light and heavy chain pairs. The N-termini of one or both light and heavy chain pairs are linked via linkers comprising a protease cleavage site to coiled-coil forming peptides that associate to form a coiled coil reducing binding affinity of at least one light-heavy chain pair to a target.
    Type: Application
    Filed: December 8, 2017
    Publication date: November 21, 2019
    Applicant: SEATTLE GENETICS, INC.
    Inventors: Vivian TRANG, Matthew R. LEVENGOOD, Peter SENTER