Patents by Inventor Matthew R. MacEwan
Matthew R. MacEwan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240115296Abstract: Provided herein is a scaffold for growing bone, comprising a randomized porosity pattern typical of native trabecular bone. The present disclosure also provides a medical device comprising a scaffold disclosed herein.Type: ApplicationFiled: November 4, 2023Publication date: April 11, 2024Applicant: Allumin8, Inc.Inventors: Alyssa Huffmann, Matthew R MacEwan, Michael J Milella, JR., Michael Sherman, Charlie Barfield, Matthew Shomper
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Publication number: 20230347023Abstract: A three-dimensional electrospun biomedical patch includes a first polymeric scaffold having a first structure of deposited electrospun fibers extending in a plurality of directions in three dimensions to facilitate cellular migration for a first period of time upon application of the biomedical patch to a tissue, wherein the first period of time is less than twelve months, and a second polymeric scaffold having a second structure of deposited electrospun fibers. The second structure of deposited electrospun fibers includes the plurality of deposited electrospun fibers configured to provide structural reinforcement for a second period of time upon application of the three-dimensional electrospun biomedical patch to the tissue wherein the second period of time is less than twelve months. The three-dimensional electrospun biomedical patch is sufficiently pliable and resistant to tearing to enable movement of the three-dimensional electrospun biomedical patch with the tissue.Type: ApplicationFiled: January 25, 2023Publication date: November 2, 2023Inventor: Matthew R. MacEwan
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Publication number: 20230074964Abstract: Some embodiments described herein are directed to non-woven graft materials for use in specialized surgical procedures such as neurosurgical procedures, methods for making the non-woven graft materials, and methods for repairing tissue such as neurological tissue using the non-woven graft materials.Type: ApplicationFiled: September 6, 2022Publication date: March 9, 2023Inventors: Matthew R. MacEwan, Lily Jeng, Abdolrasol Rahimi, Manisha Jassal, Tamas Kovacs
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Patent number: 11596717Abstract: A three-dimensional electrospun biomedical patch includes a first polymeric scaffold having a first structure of deposited electrospun fibers extending in a plurality of directions in three dimensions to facilitate cellular migration for a first period of time upon application of the biomedical patch to a tissue, wherein the first period of time is less than twelve months, and a second polymeric scaffold having a second structure of deposited electrospun fibers. The second structure of deposited electrospun fibers includes the plurality of deposited electrospun fibers configured to provide structural reinforcement for a second period of time upon application of the three-dimensional electrospun biomedical patch to the tissue wherein the second period of time is less than twelve months. The three-dimensional electrospun biomedical patch is sufficiently pliable and resistant to tearing to enable movement of the three-dimensional electrospun biomedical patch with the tissue.Type: GrantFiled: January 14, 2022Date of Patent: March 7, 2023Assignee: Washington UniversityInventor: Matthew R. MacEwan
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Publication number: 20230053327Abstract: A multi-laminar electrospun nanofiber scaffold for use in repairing a defect in a tissue substrate is provided. The scaffold includes a first layer formed by a first plurality of electrospun polymeric fibers, and a second layer formed by a second plurality of electrospun polymeric fibers. The second layer is combined with the first layer. A first portion of the scaffold includes a higher density of fibers than a second portion of the scaffold, and the first portion has a higher tensile strength than the second portion. The scaffold is configured to degrade via hydrolysis after at least one of a predetermined time or an environmental condition. The scaffold is configured to be applied to the tissue substrate containing the defect, and is sufficiently flexible to facilitate application of the scaffold to uneven surfaces of the tissue substrate, and to enable movement of the scaffold by the tissue substrate.Type: ApplicationFiled: June 25, 2021Publication date: February 16, 2023Inventors: Matthew R. MacEwan, Jingwei Xie, Zack Ray, Younan Xia
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Publication number: 20230030107Abstract: Disclosed herein are embodiments of a non-woven hybrid-scale fiber matrix sheet which can be used to improve wound healing. The non-woven hybrid-scale fiber matrix sheet may be both microporous, due to the hybrid-scale fiber matrix , as well as macroporous through the addition of cuts or perforations in the hybrid-scale fiber matrix sheet. The micro and macroporous sheet can improve biological healing at a wound site.Type: ApplicationFiled: July 29, 2022Publication date: February 2, 2023Inventors: Matthew R. MacEwan, Lily Jeng, Abdolrasol Rahimi, Manisha Jassal, Tamas Kovacs
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Publication number: 20230033599Abstract: Particles of non-woven graft materials for use in specialized surgical procedures such as soft tissue repair and wound management procedures, methods for making the powder, and methods for repairing tissue such as neurological tissue using the powder are disclosed. The particles can advantageously be used to fill irregular shaped areas or can be used in conjunction with non-woven graft materials.Type: ApplicationFiled: July 29, 2022Publication date: February 2, 2023Inventors: Matthew R. MACEWAN, Lily JENG, Abdolrasol RAHIMI, Manisha JASSAL, Tamas KOVACS
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Patent number: 11471260Abstract: A multi-laminar electrospun nanofiber scaffold for use in repairing a defect in a tissue substrate is provided. The scaffold includes a first layer formed by a first plurality of electrospun polymeric fibers, and a second layer formed by a second plurality of electrospun polymeric fibers. The second layer is combined with the first layer. A first portion of the scaffold includes a higher density of fibers than a second portion of the scaffold, and the first portion has a higher tensile strength than the second portion. The scaffold is configured to degrade via hydrolysis after at least one of a predetermined time or an environmental condition. The scaffold is configured to be applied to the tissue substrate containing the defect, and is sufficiently flexible to facilitate application of the scaffold to uneven surfaces of the tissue substrate, and to enable movement of the scaffold by the tissue substrate.Type: GrantFiled: October 27, 2020Date of Patent: October 18, 2022Assignee: Washington UniversityInventors: Matthew R. MacEwan, Jingwei Xie, Zack Ray, Younan Xia
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Publication number: 20220249743Abstract: A three-dimensional electrospun biomedical patch includes a first polymeric scaffold having a first structure of deposited electrospun fibers extending in a plurality of directions in three dimensions to facilitate cellular migration for a first period of time upon application of the biomedical patch to a tissue, wherein the first period of time is less than twelve months, and a second polymeric scaffold having a second structure of deposited electrospun fibers. The second structure of deposited electrospun fibers includes the plurality of deposited electrospun fibers configured to provide structural reinforcement for a second period of time upon application of the three-dimensional electrospun biomedical patch to the tissue wherein the second period of time is less than twelve months. The three-dimensional electrospun biomedical patch is sufficiently pliable and resistant to tearing to enable movement of the three-dimensional electrospun biomedical patch with the tissue.Type: ApplicationFiled: January 14, 2022Publication date: August 11, 2022Inventor: Matthew R. MacEwan
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Publication number: 20220175510Abstract: A structure of aligned (e.g., radially and/or polygonally aligned) fibers, and systems and methods for producing and using the same. One or more structures provided may be created using an apparatus that includes one or more first electrodes that define an area and/or partially circumscribe an area. For example, a single first electrode may enclose the area, or a plurality of first electrode(s) may be positioned on at least a portion of the perimeter of the area. A second electrode is positioned within the area. Electrodes with rounded (e.g., convex) surfaces may be arranged in an array, and a fibrous structure created using such electrodes may include an array of wells at positions corresponding to the positions of the electrodes.Type: ApplicationFiled: July 23, 2021Publication date: June 9, 2022Inventors: Matthew R. MacEwan, Jingwei Xie, Zack Ray, Younan Xia
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Publication number: 20220151741Abstract: Systems and methods are provided for enhancing osseointegration performed in conjunction with placing a dental implant. A dental implant post can be used for applying current to the implant site as well as for anchoring an artificial tooth. Such a dual purpose implant can allow faster healing and osseointegration time as well as enabling the use of dental implants in a large segment of the population currently disqualified from such treatment due to poor bone quality.Type: ApplicationFiled: March 2, 2018Publication date: May 19, 2022Inventors: Eric C. LEUTHARDT, Daniel W. MORAN, Matthew R. MacEWAN MacEWAN
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Patent number: 11311366Abstract: A structure of aligned (e.g., radially and/or polygonally aligned) fibers, and systems and methods for producing and using the same. One or more structures provided may be created using an apparatus that includes one or more first electrodes that define an area and/or partially circumscribe an area. For example, a single first electrode may enclose the area, or a plurality of first electrode(s) may be positioned on at least a portion of the perimeter of the area. A second electrode is positioned within the area. Electrodes with rounded (e.g., convex) surfaces may be arranged in an array, and a fibrous structure created using such electrodes may include an array of wells at positions corresponding to the positions of the electrodes.Type: GrantFiled: April 26, 2017Date of Patent: April 26, 2022Assignee: Washington UniversityInventors: Matthew R. MacEwan, Jingwei Xie, Zack Ray, Younan Xia
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Patent number: 11253635Abstract: A three-dimensional electrospun biomedical patch includes a first polymeric scaffold having a first structure of deposited electrospun fibers extending in a plurality of directions in three dimensions to facilitate cellular migration for a first period of time upon application of the biomedical patch to a tissue, wherein the first period of time is less than twelve months, and a second polymeric scaffold having a second structure of deposited electrospun fibers. The second structure of deposited electrospun fibers includes the plurality of deposited electrospun fibers configured to provide structural reinforcement for a second period of time upon application of the three-dimensional electrospun biomedical patch to the tissue wherein the second period of time is less than twelve months. The three-dimensional electrospun biomedical patch is sufficiently pliable and resistant to tearing to enable movement of the three-dimensional electrospun biomedical patch with the tissue.Type: GrantFiled: July 21, 2021Date of Patent: February 22, 2022Assignee: Washington UniversityInventor: Matthew R. MacEwan
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Publication number: 20220040476Abstract: A system for stimulating tissue generally comprises a resorbable implant. The resorbable implant includes a substrate, at least one contact, and a transceiver, wherein the substrate, the at least one contact, and the transceiver are resorbable. The system also includes a controller configured to communicate with the transceiver of the resorbable implant and a power supply connected to the controller. The controller delivers power to the resorbable implant from the power supply. The resorbable implant delivers electrical stimulation to tissue when the resorbable implant receives power.Type: ApplicationFiled: October 21, 2021Publication date: February 10, 2022Inventors: Wilson Z. Ray, Matthew R. MacEwan, Zohny S. Zohny, John A. Rogers
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Patent number: 11179564Abstract: A system for stimulating tissue generally comprises a resorbable implant. The resorbable implant includes a substrate, at least one contact, and a transceiver, wherein the substrate, the at least one contact, and the transceiver are resorbable. The system also includes a controller configured to communicate with the transceiver of the resorbable implant and a power supply connected to the controller. The controller delivers power to the resorbable implant from the power supply. The resorbable implant delivers electrical stimulation to tissue when the resorbable implant receives power.Type: GrantFiled: April 25, 2018Date of Patent: November 23, 2021Assignees: Washington University, Northwestern UniversityInventors: Wilson Z. Ray, Matthew R. MacEwan, Zohny S. Zohny, John A. Rogers
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Publication number: 20210353834Abstract: A three-dimensional electrospun biomedical patch includes a first polymeric scaffold having a first structure of deposited electrospun fibers extending in a plurality of directions in three dimensions to facilitate cellular migration for a first period of time upon application of the biomedical patch to a tissue, wherein the first period of time is less than twelve months, and a second polymeric scaffold having a second structure of deposited electrospun fibers. The second structure of deposited electrospun fibers includes the plurality of deposited electrospun fibers configured to provide structural reinforcement for a second period of time upon application of the three-dimensional electrospun biomedical patch to the tissue wherein the second period of time is less than twelve months. The three-dimensional electrospun biomedical patch is sufficiently pliable and resistant to tearing to enable movement of the three-dimensional electrospun biomedical patch with the tissue.Type: ApplicationFiled: July 21, 2021Publication date: November 18, 2021Inventor: Matthew R. MacEwan
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Patent number: 11173234Abstract: A three-dimensional electrospun nanofiber scaffold for use in repairing a defect in a tissue substrate is provided. The three-dimensional electrospun nanofiber scaffold includes a first layer formed by a first plurality of electrospun polymeric fibers and a second layer formed by a second plurality of electrospun polymeric fibers. The second layer is coupled to the first layer using a coupling process and includes a plurality of varying densities formed by the second plurality of electrospun polymeric fibers. The first and second layers are configured to degrade via hydrolysis after at least one of a predetermined time or an environmental condition. The three-dimensional electrospun nanofiber scaffold is configured to be applied to the tissue substrate containing the defect.Type: GrantFiled: April 13, 2021Date of Patent: November 16, 2021Assignee: Washington UniversityInventor: Matthew R. MacEwan
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Patent number: 11167132Abstract: A system to deliver current to an area of interest of a subject is described that includes a power source, a controller electrically coupled to the power source, at least one first electrode electrically coupled to the controller, and at least one second electrode electrically coupled to one of the power source and the controller, with the area of interest positioned between the at least one first electrode and the at least one second electrode. A method of stimulating at least one of bone growth, tissue healing and pain control within an area of interest of a patient is described that includes inserting first and second electrode spaced at a predetermined distance, and further includes directing an electric current between the first and second electrodes so that at least a portion of the electric current passes through the area of interest positioned between the first electrode and the second electrode.Type: GrantFiled: May 13, 2019Date of Patent: November 9, 2021Assignee: Washington UniversityInventors: Eric Claude Leuthardt, Daniel W. Moran, Matthew R. MacEwan
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Publication number: 20210338408Abstract: A multi-laminar electrospun nanofiber scaffold for use in repairing a defect in a tissue substrate is provided. The scaffold includes a first layer formed by a first plurality of electrospun polymeric fibers, and a second layer formed by a second plurality of electrospun polymeric fibers. The second layer is combined with the first layer. A first portion of the scaffold includes a higher density of fibers than a second portion of the scaffold, and the first portion has a higher tensile strength than the second portion. The scaffold is configured to degrade via hydrolysis after at least one of a predetermined time or an environmental condition. The scaffold is configured to be applied to the tissue substrate containing the defect, and is sufficiently flexible to facilitate application of the scaffold to uneven surfaces of the tissue substrate, and to enable movement of the scaffold by the tissue substrate.Type: ApplicationFiled: June 25, 2021Publication date: November 4, 2021Inventors: Matthew R. MacEwan, Jingwei Xie, Zack Ray, Younan Xia
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Publication number: 20210267746Abstract: A structure of aligned (e.g., radially and/or polygonally aligned) fibers, and systems and methods for producing and using the same. One or more structures provided may be created using an apparatus that includes one or more first electrodes that define an area and/or partially circumscribe an area. For example, a single first electrode may enclose the area, or a plurality of first electrode(s) may be positioned on at least a portion of the perimeter of the area. A second electrode is positioned within the area. Electrodes with rounded (e.g., convex) surfaces may be arranged in an array, and a fibrous structure created using such electrodes may include an array of wells at positions corresponding to the positions of the electrodes.Type: ApplicationFiled: April 13, 2021Publication date: September 2, 2021Inventors: Matthew R. MacEwan, Jingwei Xie, Zack Ray, Younan Xia