Patents by Inventor Matthew R. Powers

Matthew R. Powers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NEW PROCESS FOR PREPARING 2-(3--PHENYL)-2-METHYLPROPRIONIC ACID
    Publication number: 20100184979
    Abstract: This invention is directed to a process for preparing 2-(3-{6-[2-(2,4-dichloro-phenyl)-ethylamino]-2-methoxy-pyrimidin-4-yl}-phenyl)-2-methyl-propionic acid.
    Type: Application
    Filed: December 16, 2009
    Publication date: July 22, 2010
    Applicant: SANOFI-AVENTIS
    Inventors: Reda G. HANNA, Elizabeth SECORD, Bao-Guo HUANG, Matthew R. POWERS
  • STABLE NON-HYGROSCOPIC CRYSTALLINE FORM OF N-[N-[N-(4-(PIPERIDIN-4-YL)BUTANOYL)-N-ETHYLGLYCYL]ASPARTYL]-L-&bgr;-CYCLOHEXYL ALANINE AMIDE, INTERMEDIATES THEREOF, AND PREPARATION THEREOF AND OF ANTITHROMBOTIC AZACYCLOALKYLALKANOYL PEPTIDES AND PSEUDOPEPTIDES
    Patent number: 6753409
    Abstract: The invention is directed to a non-hygroscopic stable crystalline form of the antithrombotic compound N-[N-[N-(4-piperdin-4-yl)butanoyl)-N-ethylglycyl]-(L)-aspartyl]-(L)-&bgr;-cyclohexyl-alanine amide, to processes for preparing said stable crystalline form, to a pharmaceutical composition thereof, and intermediates thereof, and the invention is directed also to processes for preparing a compound of the formula wherein: A, B, Z, E1, E2, G, R, m, n, and p are as defined herein.
    Type: Grant
    Filed: August 15, 2000
    Date of Patent: June 22, 2004
    Assignee: Aventis Pharmaceuticals Inc.
    Inventors: Zofia J. Chrzan, James J. Mencel, David Toledo-Velasquez, Vincent Windisch, Rick G. Woodward, Diane C. Salazar, Narasimha M. Vemuri, Anthony J. Gardetto, Matthew R. Powers, Gregory G. Kubiak, Robert C. Liu, Benoit J. Vanasse, James P. Sherbine, Walter Rodriguez, Adam W. Sledeski
  • Novel processes for the preparation of adenosine compounds and intermediates thereto
    Publication number: 20030069423
    Abstract: Novel processes for the preparation of adenosine compounds and intermediates thereto. The adenosine compounds prepared by the present processes may be useful as cardiovascular agents, more particularly as antihypertensive and anti-ischemic agents, as cardioprotective agents which ameliorate ischemic injury or myocardial infarct size consequent to myocardial ischemia, and as an antilipolytic agents which reduce plasma lipid levels, serum triglyceride levels, and plasma cholesterol levels. The present processes may offer improved yields, purity, ease of preparation and/or isolation of intermediates and final product, and more industrially useful reaction conditions and workability.
    Type: Application
    Filed: May 10, 2002
    Publication date: April 10, 2003
    Inventors: Timothy A. Ayers, Geoffrey A. D'Netto, Gregory G. Kubiak, James J. Mencel, Michael K. O'Brien, Matthew R. Powers, John J. Shay, Adam W. Sledeski, David S. Teager, Benoit Vanasse
  • Steroespecific preparation of chiral 1-aryl- and 1-heteroaryl-2-substituted ethyl-2-amines
    Patent number: 6433172
    Abstract: This invention is directed to methods for stereospecifically preparing [(1-optionally substituted aryl)- or (1-optionally substituted heteroaryl)]-2-substituted ethyl-2-amines, having chirality at the 2-position, and to intermediates to the substituted ethyl-2-amines.
    Type: Grant
    Filed: October 25, 1999
    Date of Patent: August 13, 2002
    Assignee: Aventis Pharmaceuticals Inc.
    Inventors: Luc Grondard, Jean-Paul Casimir, Patrick Leon, Michael K. O'Brien, Matthew R. Powers, Daniel Robin
  • Process for preparing N6-substituted adenosine derivatives
    Patent number: 6429315
    Abstract: This invention is directed to a process for preparing N6-substituted adenosine derivatives, to intermediates useful therefor and to methods of preparing these intermediates.
    Type: Grant
    Filed: January 21, 2000
    Date of Patent: August 6, 2002
    Assignee: Aventis Pharmaceuticals Inc.
    Inventors: Adam W. Sledeski, Luc Grondard, Matthew R. Powers, Tory H. Powner, Michael K. O'Brien, Ching T. Tsuei, Patrick Leon, Gregory G. Kubiak, Laurence Pailleres-Hubert, Benoit Viguier
  • Process for preparing N6-substituted adenosine derivatives
    Patent number: 6184382
    Abstract: The invention is directed to improved methods for preparing N6-substituted adenosine derivatives, to intermediates useful therefor and to methods of preparing these intermediates.
    Type: Grant
    Filed: January 12, 2000
    Date of Patent: February 6, 2001
    Assignee: Aventis Pharmaceuticals Products Inc.
    Inventors: Diane C. Salazar, Walter Rodriguez, James P. Sherbine, Rick G. Woodward, Adam W. Sledeski, Matthew R. Powers, Michael K. O'Brien
  • Stable non-hygroscopic crystalline form of N-[N-[N-4-(piperidin-4-yl)butanoyl)-N-ethylglycyl] aspartyl]-L-.beta.-cyclohexyl alanine amide
    Patent number: 6153588
    Abstract: The invention is directed to a non-hygroscopic stable crystalline form of the antithrombotic compound N-[N-[N-(4-piperdin-4-yl)butanoyl)-N-ethylglycyl]-(L)-aspartyl]-(L)-.beta. -cyclohexyl-alanine amide, to processes for preparing said stable crystalline form, to a pharmaceutical composition thereof, and intermediates thereof, and the invention is directed also to processes for preparing a compound of the formula ##STR1## wherein: A, B, Z, E.sup.1, E.sup.2, G, R, m, n, and p are as defined herein.
    Type: Grant
    Filed: February 18, 1999
    Date of Patent: November 28, 2000
    Assignee: Aventis Pharmaceuticals Products Inc.
    Inventors: Zofia J. Chrzan, James J. Mencel, David Toledo-Velasquez, Vincent Windisch, Rick G. Woodward, Diane C. Salazar, deceased, Narasimha M. Vemuri, Anthony J. Gardetto, Matthew R. Powers, Gregory G. Kubiak, Robert C. Liu, Benoit J. Vanasse, James P. Sherbine, Walter Rodriguez, Adam W. Sledeski
  • Stereospecific preparation of chiral 1-aryl-and 1-heteroaryl-2-substituted ethyl-2-amines
    Patent number: 6127550
    Abstract: This invention is directed to methods for stereospecifically preparing [(1-optionally substituted aryl)- or (1-optionally substituted heteroaryl)]-2-substituted ethyl-2-amines, having chirality at the 2-position, and to intermediates to the substituted ethyl-2-amines.
    Type: Grant
    Filed: March 11, 1999
    Date of Patent: October 3, 2000
    Assignee: Rhone-Poulenc Rorer Pharmaceuticals Inc.
    Inventors: Luc Grondard, Jean-Paul Casimir, Patrick Leon, Michael K. O'Brien, Matthew R. Powers, Daniel Robin
  • 2,6-methano-2H-1-benzoxocincarboxylic acids, esters and amides
    Patent number: 5288731
    Abstract: Novel compounds which are 2,6-methano-2H-1-benzoxocincarboxamides having 5-HT.sub.3 -antagonist properties including unique CNS, antiemetic and gastric prokinetic activities and which are void of any significant D.sub.2 receptor binding affinity, therapeutic compositions and methods of treatment of disorders which result from 5-HT.sub.3 activity using said compounds. Processes for their preparation and the preparation of their intermediates are also disclosed.
    Type: Grant
    Filed: August 5, 1992
    Date of Patent: February 22, 1994
    Assignee: Rhone-Poulenc Rorer Pharmaceuticals Inc.
    Inventors: John E. Airey, Matthew R. Powers, Walter Rodriguez, Raymond D. Youssefyeh
  • Process for preparing chiral dibenzofurans via intramolecular heck reaction
    Patent number: 5278323
    Abstract: The present invention is directed to the synthesis of 2-chloro-cis-[5a(S)-9a(S)-(5a,6,7,8,9,9a-hexahydro)]dibenzofuran-4-carboxy lic acid by an intramolecular Heck stereospecific synthesis substantially free of undesirable 8-chloro-2,6-methano-2H-3,4,5,6-tetrahydro-1-benzoxocin-10-carboxylic.
    Type: Grant
    Filed: April 30, 1993
    Date of Patent: January 11, 1994
    Assignee: Rhone-Poulenc Rorer Pharmaceuticals Inc.
    Inventor: Matthew R. Powers
  • Pharmaceutically useful dibenzofurancarboxamides of specific stereo-configuration
    Patent number: 5246942
    Abstract: This invention is directed to certain dibenzofurancarboxamides and their use as 5HT.sub.3 antagonists having unique CNS, anti-emetic and gastric prokinctic activity void of any significant D.sub.2 receptor binding properties. This invention also describes novel processes necessary for their preparation.
    Type: Grant
    Filed: May 29, 1992
    Date of Patent: September 21, 1993
    Assignee: Rhone-Poulenc Rorer Pharmaceuticals Inc.
    Inventors: Raymond D. Youssefyeh, Henry F. Campbell, Donald E. Kuhla, John E. Airey, Scott I. Klein, Matthew R. Powers
  • Process for the preparation of optically pure amides
    Patent number: 5086179
    Abstract: This invention is directed to certain dibenzofurancarboxamides and dibenzofurancarboxamide acids and their use as 5HT.sub.3 antagonists having unique CNS, anti-emetic and gastric prokinetic activity void of any significant D.sub.2 receptor binding properties. Further, this invention relates to a process for the synthesis of stereoisomeric compounds having such CNS, anti-emetic and gastric prokinetic activity.
    Type: Grant
    Filed: September 24, 1990
    Date of Patent: February 4, 1992
    Assignee: Rhone-Poulenc Rorer Pharmaceuticals Inc.
    Inventors: Matthew R. Powers, Raymond D. Youssefyeh, William L. Studt, Frederick A. Golec
  • Process for preparing dibenzofurans via catalytic heteroannulation
    Patent number: H1406
    Abstract: The present invention is directed to the synthesis of 2-chloro-cis-[5a(S)-9a(S)-(5a,6,7,8,9,9a-hexahydro)]dibenzofuran-4-carboxy lic acid by a stereospecific catalytic heteroannulation synthesis free of undesirable 8-chloro-2,6-methano-2H-3,4,5,6-tetrahydro-1-benzoxocin-10-carboxylic.
    Type: Grant
    Filed: April 30, 1993
    Date of Patent: January 3, 1995
    Assignee: Rhone Poulenc Rorer Pharmaceuticals Inc.
    Inventor: Matthew R. Powers