Patents by Inventor MATTHEW RAAB

MATTHEW RAAB has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method to monitor and quantify interphase nuclear envelope rupture events
    Patent number: 10969389
    Abstract: The present invention provides an in vitro method for monitoring interphase nuclear envelope rupture events in a eukaryotic cell or screening or identifying compound capable of increasing or decreasing the intensity and/or frequency of interphase nuclear envelope rupture events in a eukaryotic cell. These methods relate on a protein having a cytosolic non-nuclear localization in interphase and a non-sequence specific DNA binding activity. Interphase nuclear envelope rupture events are characterized by the presence of the protein of the invention in the nucleus of the eukaryotic cell.
    Type: Grant
    Filed: February 17, 2017
    Date of Patent: April 6, 2021
    Assignees: INSTITUT CURIE, INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Matthieu Piel, Matteo Gentili, Matthew Raab, Nicolas Manel
  • METHOD TO MONITOR AND QUANTIFY INTERPHASE NUCLEAR ENVELOPE RUPTURE EVENTS
    Publication number: 20190033311
    Abstract: The present invention provides an in vitro method for monitoring interphase nuclear envelope rupture events in a eukaryotic cell or screening or identifying compound capable of increasing or decreasing the intensity and/or frequency of interphase nuclear envelope rupture events in a eukaryotic cell. These methods relate on a protein having a cytosolic non-nuclear localization in interphase and a non-sequence specific DNA binding activity. Interphase nuclear envelope rupture events are characterized by the presence of the protein of the invention in the nucleus of the eukaryotic cell.
    Type: Application
    Filed: February 17, 2017
    Publication date: January 31, 2019
    Inventors: MATTHIEU PIEL, MATTEO GENTILI, MATTHEW RAAB, NICOLAS MANEL