Abstract: Certain aspects of the present disclosure provide techniques for an end effector system. The end effector system includes an end effector coupled to a gimbal assembly, wherein the end effector is configured to grasp an object and the gimbal assembly is attached to a shaft. The end effector system includes a first actuator coupled to the shaft and configured to move the shaft and a self-alignment assembly. The self-alignment assembly includes a first surface coupled to the end effector and a second surface coupled to the first actuator and configured to interface with the first surface, wherein the first actuator is configured to move the shaft such that the first surface engages the second surface to position the gimbal assembly at a first position.

Abstract: The present invention is directed to methods for detecting or measuring Notch activation by observing or measuring the appearance of Notch on the cell surface or by observing or measuring Notch cleavage products that are indicative of Notch activation. The present invention is also directed to methods for detecting a molecule that modulates Notch activation by observing or measuring a change in the amount of Notch expressed on the cell surface or a change in the amount or pattern of Notch cleavage products. The present invention is also directed to a substantially purified activated heterodimeric form of Notch and components thereof and pharmaceutical compositions and kits thereof. The present invention is based, at least in part, on the discovery that Notch in its active form, i.e.