Abstract: Described herein are compounds of Formula I, wherein the variables are defined herein, their use as branched-chain alpha keto acid dehydrogenase kinase inhibitors and/or degraders, pharmaceutical compositions containing such compounds and their use to treat, for example, diabetes, kidney disease, NASH and heart failure.

Abstract: Exemplary embodiments are directed to a multi-modal biometric analysis system including one or more illumination sources, one or more cameras, and a processing device. The illumination sources are configured to illuminate an iris of a subject. The cameras are configured to capture one or more images of the subject during illumination of the subject with the one or more illumination sources. The images include iris biometric data associated with the iris of the subject and face biometric data associated with a face of the subject. The processing device receives as input the one or more images, analyzes the iris biometric data for iris biometric authenticity, analyzes the face biometric data for face biometric authenticity, and compares the iris biometric data and the face biometric data to determine the biometric authenticity of the subject.

Abstract: A clamp apparatus is disclosed that includes a body, first and second actuators, first, second, third and fourth gear sets, first and second movable grippers, and at least one leaf spring. The first gear set is coupled to the first actuator and the second gear set is coupled to the second actuator. The first gear set engages the second gear set. The first and second movable grippers are each operatively coupled to the body. The third gear set is coupled to the first movable gripper and the fourth gear set is coupled to the second movable gripper. The third gear set operatively engages the fourth gear set. The leaf spring engages with the third gear set and the fourth gear set to urge the first movable gripper and the second movable gripper toward a clamped position.

Abstract: Compositions and methods for isolating L-glufosinate from a composition comprising L-glufosinate and glutamate are provided. The method comprises converting the glutamate to pyroglutamate followed by the isolation of L-glufosinate from the pyroglutamate and other components of the composition to obtain substantially purified L-glufosinate. The composition comprising L-glufosinate and glutamate is subjected to an elevated temperature for a sufficient time to allow for the conversion of glutamate to pyroglutamate, followed by the isolation of L-glufosinate from the pyroglutamate and other components of the composition to obtain substantially purified L-glufosinate. The glutamate alternatively may be converted to pyroglutamate by enzymatic conversion. The purified L-glufosinate is present in a final composition at a concentration of 90% or greater of the sum of L-glufosinate, glutamate, and pyroglutamate.

Abstract: The invention relates to compounds of Formula I? wherein R, R1, R2, R3, p, q and q? are as defined herein, pharmaceutical compositions comprising the compounds, methods of treating coronavirus infection such as COVID-19 in a patient by administering therapeutically effective amounts of the compounds, and methods of inhibiting or preventing replication of coronaviruses such as SARS-CoV-2 with the compounds.

Abstract: Hybrid on-policy/off-policy techniques are provided for improving the estimation of quality (reward) of a control policy for decision making by combining the on-policy and off-policy data from multiple estimators into a single metric. In one aspect, a method for estimating a reward of a policy for decision making in a computer system includes: computing multiple reward estimates of the policy using estimators, wherein at least a subset of the estimators compute reward estimates with prediction intervals; and combining the multiple reward estimates using a combiner to produce a new reward estimate. Thus, some of the estimators might compute the reward estimates without prediction intervals. A method for estimating a reward of a policy when another one or more of the estimators compute reward estimates without prediction intervals is also provided.

Abstract: Provided are computer program product, system, and method for managing data structures in a plurality of memory devices that are indicated to demote after initialization of the data structures. Indication is made to data structures to demote after initialization from a first level memory device to a second level memory device. The first level memory device has lower latency than the second level memory device. In response to completing initialization of the data structures in the first level memory device, the data structures indicated to demote after initialization are copied from the first level memory device to the second level memory device and removing the data structures indicate to move after initialization from the first level memory device.

Abstract: A washware rack assembly including: a basket formed by a plurality of wire-shaped elements, the plurality of wire-shaped elements including a bottom portion and a side wall portion; and a plurality of removable, preformed rows of tines configured to mount to the basket. The plurality of removable, preformed rows of tines include tines having a first, fixed spacing and tines having a second, fixed spacing which is different than the first, fixed spacing. A pair of the removable, preformed rows of tines having the first, fixed spacing is disposed in parallel in one section of the basket, and a pair of the removable, preformed rows of tines having the second, fixed spacing is disposed in parallel in another section of the basket, such that the washware rack assembly is configured to accommodate washware of different sizes in different sections of the basket.

Abstract: Guard-railed security benchmark compliance assurance includes storing in memory of a computer a multiplicity of specific parameter values, retrieving from memory, different parameterized operating system directives arranged together in a programmatic module, populating different parameters of the directives with respective ones of the stored specific parameter values and invoking each of the directives with the populated different parameters through a command line shell of an operating system executing in the computer, each invocation establishing a different configuration setting in a computing environment hosted by the computer.

Abstract: A durability assessment system may receive a request, from a computing system, for a durability index describing an entity. The durability assessment system may determine the durability index based on information about the resource usage by the entity, such as a resource availability score or a resource allocation score. The durability assessment system may compare the obtained resource availability score and resource allocation score to ranges associated with a set of durability indices. Based on the comparison, the durability assessment system may determine a durability index for the entity. The durability index may indicate an ability of the entity to return accessed resources. In some cases, the durability assessment system may provide the durability index to an allocation computing system that is configured to determine whether to grant access to resources based on the durability index.

Abstract: A method and apparatus for removing specific contaminants from an aqueous solution in a recirculating tank or linear treatment system is described. An aqueous solution is pumped into a reaction chamber. Measurements from the aqueous solution are collected, including one or more of Free Chlorine, Total Chlorine, Total Ammonia Nitrogen, pH, bacteria in the tank, and Oxidation Reduction Potential. In response to the measurements collected, one or more of pump speed, injection of pH precursors prior to the reaction chamber, reaction chamber electrode voltage, current, infusion rate of the chlorine, and contact time of the aqueous solution with the chlorine, are adjusted.

Abstract: Novel insecticidal proteins that are toxic to lepidopteran pests are disclosed. The DNA encoding the insecticidal proteins can be used to transform prokaryotic and eukaryotic organisms to express the insecticidal proteins. The recombinant organisms or compositions containing the recombinant organisms or the insecticidal proteins alone or in combination with an appropriate agricultural carrier can be used to control lepidopteran pests in various environments.

Abstract: In exemplary aspects of optimizing data centers, historical data corresponding to a data center is collected. The data center includes a plurality of systems. A data center representation is generated. The data center representation can be one or more of a schematic and a collection of data from among the historical data. The data center representation is encoded into a neural network model. The neural network model is trained using at least a portion of the historical data. The trained model is deployed using a first set of inputs, causing the model to generate one or more output values for managing or optimizing the data center with respect to design and risk aspects.

Abstract: Provided are a computer program product, system, and method for maintaining data structures in a virtual memory comprised of a plurality of heterogeneous memory devices. Access counts are maintained for a plurality of data structures stored in a first level memory device. A determination is made of data structures in the first level memory device having lowest access counts. The determined data structures are deleted from the first level memory device and retaining copies of the data structures in a second level memory device, wherein the first level memory device has lower latency than the second level memory device.

Abstract: Embodiments are provided herein for low loss coupling capacitor structures. The embodiments include a n-type varactor (NVAR) configuration and p-type varactor (PVAR) configuration. The structure in the NVAR configuration comprises a p-doped semiconductor substrate (Psub), a deep n-doped semiconductor well (DNW) in the Psub, and a p-doped semiconductor well (P well) in the DNW. The circuit structure further comprises a source terminal of a p-doped semiconductor material within P well, and a drain terminal of the p-doped semiconductor material within the P well. Additionally, the circuit structure comprises an insulated gate on the surface of the P well, a metal pattern comprising a plurality of layers of metal lines, and a plurality of vias through the metal lines. The vias are contacts connecting the metal lines to the gate, the source terminal, and the drain terminal.

Abstract: A durability assessment system may receive a request, from a computing system, for a durability index describing an entity. The durability assessment system may determine the durability index based on information about the resource usage by the entity, such as a resource availability score or a resource allocation score. The durability assessment system may compare the obtained resource availability score and resource allocation score to ranges associated with a set of durability indices. Based on the comparison, the durability assessment system may determine a durability index for the entity. The durability index may indicate an ability of the entity to return accessed resources. In some cases, the durability assessment system may provide the durability index to an allocation computing system that is configured to determine whether to grant access to resources based on the durability index.

Abstract: The disclosure relates to technology for an apparatus having a current conveyer comprising a first stage having a first differential input, and a second stage having a second differential input. The first and second stages are configured to operate in a push-pull mode to provide an output signal at a current conveyer output between the first stage and the second stage. The apparatus has a first frequency mixer configured to generate a first mixer signal based on an input signal and an oscillator signal having a first frequency. The first frequency mixer is configured to provide the first mixer signal to the first differential input. The apparatus has a second frequency mixer configured to generate a second mixer signal based on the input signal and a second oscillator signal having the first frequency. The second frequency mixer is configured to provide the second mixer signal to the second differential input.

Abstract: The invention relates to compounds of Formula I? wherein R, R1, R2, R3, p, q and q? are as defined herein, pharmaceutical compositions comprising the compounds, methods of treating coronavirus infection such as COVID-19 in a patient by administering therapeutically effective amounts of the compounds, and methods of inhibiting or preventing replication of coronaviruses such as SARS-CoV-2 with the compounds.