Abstract: Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.

Abstract: An internal combustion engine system is disclosed that improves regulation of engine speed relative to a speed setpoint. The system controls ignition timing, throttle plate actuation, fuel valve actuation or a combination thereof in accordance with maintaining a setpoint speed. The system also includes a transient air flow estimation for further improving setpoint speed accuracy.

Abstract: One embodiment of the present invention includes sensing speed or an internal combustion engine that includes a manifold coupled to an air pathway and a gaseous fuel line, sensing manifold pressure, and sensing manifold temperature. Air mass flow rate is determined as a function of the sensed engine spaced, manifold pressure, and manifold temperature. Fuel mass flow rate in the fuel line is sensed and fuel is controlled through the fuel line in accordance with the air mass flow rate and the fuel mass flow rate.

Abstract: An internal combustion engine system is disclosed that improves regulation of engine speed relative to a speed setpoint. The system controls ignition timing, throttle plate actuation, fuel valve actuation or a combination thereof in accordance with maintaining a setpoint speed. The system also includes a transient air flow estimation for further improving setpoint speed accuracy.

Abstract: Engine (60) has manifold (62) and includes an air pathway (20) and a fuel line (30) coupled to the manifold (62) for supplying a fuel charge. Fuel line (30) has a controllable valve (40) for regulating fuel flow and a first sensor (38) providing a fuel signal corresponding to mass flow rate of fuel through the fuel line. A second sensor (65) provides a speed signal corresponding to rotational speed of the engine. A third sensor (63) provides a temperature signal corresponding to temperature within the manifold. A fourth sensor (64) provides a pressure signal corresponding to pressure within the manifold. A fifth sensor (76) provides an exhaust signal corresponding to air/fuel ratio for combusted air and fuel in the exhaust pathway. A controller (80) responsive to the controllable valve (40) and sensors (38), (63), (64), (65), and (76) determines an air signal corresponding to the mass flow rate of air through the air pathway (20) as a function of the speed signal, temperature signal, and pressure signal.

Abstract: Engine (60) has manifold (62) and includes an air pathway (20) and a fuel line (30) coupled to the manifold (62) for supplying a fuel charge. Fuel line (30) has a controllable valve (40) for regulating fuel flow and a first sensor (38) providing a fuel signal corresponding to mass flow rate of fuel through the fuel line. A second sensor (65) provides a speed signal corresponding to rotational speed of the engine. A third sensor (63) provides a temperature signal corresponding to temperature within the manifold. A fourth sensor (64) provides a pressure signal corresponding to pressure within the manifold. A fifth sensor (76) provides an exhaust signal corresponding to air/fuel ratio for combusted air and fuel in the exhaust pathway. A controller (80) responsive to the controllable valve (40) and sensors (38), (63), (64), (65), and (76) determines an air signal corresponding to the mass flow rate of air through the air pathway (20) as a function of the speed signal, temperature signal, and pressure signal.