Patents by Inventor Matthew S. Croughan

Matthew S. Croughan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Strategy to reduce lactic acid production and control PH in animal cell culture
    Patent number: 8470552
    Abstract: The present disclosure provides a method for culturing cells in exogenous lactic acid. Certain aspects of the present disclosure include the production of recombinant proteins, such as antibodies and fragments thereof. Certain aspects of the present disclosure also relate to methods of controlling lactic acid production, pH stability and osmolality in cell culture.
    Type: Grant
    Filed: October 12, 2010
    Date of Patent: June 25, 2013
    Assignee: Keck Graduate Institute
    Inventors: Matthew S. Croughan, Nathaniel W. Freund
  • METHODS & COMPOSITIONS FOR IMPROVING PROTEIN PRODUCTION
    Publication number: 20130157356
    Abstract: The invention relates to compositions, and uses thereof, which are beneficial for eukaryotic cells in culture, and methods for their use in promoting cell growth, viability and recombinant protein expression. The methods disclosed in the present application are useful, for example, for improving cell viability and in accelerating the rate of cell growth of cells grown in culture. In one aspect, the supplements of the invention are useful for improving or enhancing the yield of the recombinant proteins from the cell cultures.
    Type: Application
    Filed: January 24, 2011
    Publication date: June 20, 2013
    Applicant: VENTRIA BIOSCIENCE
    Inventors: Michael E. Barnett, Matthew S. Croughan
  • NOVEL STRATEGY TO REDUCE LACTIC ACID PRODUCTION AND CONTROL PH IN ANIMAL CELL CULTURE
    Publication number: 20120190061
    Abstract: The present disclosure provides a method for culturing cells in exogenous lactic acid. Certain aspects of the present disclosure include the production of recombinant proteins, such as antibodies and fragments thereof. Certain aspects of the present disclosure also relate to methods of controlling lactic acid production, pH stability and osmolality in cell culture.
    Type: Application
    Filed: April 2, 2012
    Publication date: July 26, 2012
    Applicant: KECK GRADUATE INSTITUTE
    Inventors: Matthew S. Croughan, Nathaniel W. Freund
  • NOVEL STRATEGY TO REDUCE LACTIC ACID PRODUCTION AND CONTROL PH IN ANIMAL CELL CULTURE
    Publication number: 20110104734
    Abstract: The present disclosure provides a method for culturing cells in exogenous lactic acid. Certain aspects of the present disclosure include the production of recombinant proteins, such as antibodies and fragments thereof. Certain aspects of the present disclosure also relate to methods of controlling lactic acid production, pH stability and osmolality in cell culture.
    Type: Application
    Filed: October 12, 2010
    Publication date: May 5, 2011
    Applicant: Keck Graduate Institute
    Inventors: Matthew S. Croughan, Nathaniel W. Freund