Patents by Inventor Matthew S. Klee
Matthew S. Klee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8210026Abstract: A detector in a gas chromatograph includes a detector inlet configured to receive a chromatographic column, the chromatographic column having a column entrance and a column exit, the column exit coupled to the detector inlet, a restriction integrated within the detector, the restriction located to receive an output of the chromatographic column, at least one pressure regulated gas source provided for normal gas chromatograph operation and arranged to provide at least one gas to a location between the integrated restriction and the column exit, and a backflush controller coupled to the pressure regulated gas source, the backflush controller configured to control a pressure differential between the column exit and the column entrance such that the at least one gas backflushes the chromatographic column when a pressure at the column exit exceeds a pressure at the column entrance.Type: GrantFiled: December 10, 2008Date of Patent: July 3, 2012Assignee: Agilent Technologies, Inc.Inventors: Matthew S. Klee, Lawrence John Gajdos, Bruce Douglas Quimby
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Publication number: 20100139363Abstract: A detector in a gas chromatograph includes a detector inlet configured to receive a chromatographic column, the chromatographic column having a column entrance and a column exit, the column exit coupled to the detector inlet, a restriction integrated within the detector, the restriction located to receive an output of the chromatographic column, at least one pressure regulated gas source provided for normal gas chromatograph operation and arranged to provide at least one gas to a location between the integrated restriction and the column exit, and a backflush controller coupled to the pressure regulated gas source, the backflush controller configured to control a pressure differential between the column exit and the column entrance such that the at least one gas backflushes the chromatographic column when a pressure at the column exit exceeds a pressure at the column entrance.Type: ApplicationFiled: December 10, 2008Publication date: June 10, 2010Inventors: Matthew S. Klee, Lawrence John Gajdos, Bruce Douglas Quimby
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Patent number: 7503340Abstract: A system for controlling fluid flow comprises a first fluid conduit having a length, an inner diameter, an input pressure and an output pressure, and a second fluid conduit having a length, an inner diameter, an input pressure and an output pressure where the output pressure of the first fluid conduit is the input pressure of the second fluid conduit. The system also comprises a pressure sensor configured to determine the output pressure of the first fluid conduit, and a controller configured to control the output pressure of the first fluid conduit, thereby establishing a desired fluid flow through the second fluid conduit based on the length of the second fluid conduit, the inner diameter of the second fluid conduit, the temperature of the second fluid conduit and the type of fluid flowing in the second fluid conduit.Type: GrantFiled: September 30, 2005Date of Patent: March 17, 2009Assignee: Agilent Technologies, Inc.Inventors: Matthew S. Klee, Michael Q. Thompson, James D. McCurry, Paul C. Dryden
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Publication number: 20080264491Abstract: A fluid multiplexer includes a manifold having a plurality of fluid conduits formed therein, a fluid input and a plurality of fluid connection points located on the manifold and fluidically coupled together via the fluid conduits, and a flow control module coupled to the fluid connection points, the flow control module configured to provide a plurality of blocking flows to the manifold to control the flow of a primary fluid through the fluid conduits.Type: ApplicationFiled: April 27, 2007Publication date: October 30, 2008Inventors: Matthew S. Klee, Wesley Miles Norman
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Patent number: 7384457Abstract: A seal forming a fluid tight connection between a gas chromatography column and a sample inlet assembly is disclosed. The seal is formed by a metal injection molding process. The seal has a first surface adapted for sealing with the sample inlet assembly and a second surface adapted for sealing with the column. The seal has an aperture extending between the first and second surfaces. A method of sealing a connection between a gas chromatography sample inlet assembly and a gas chromatography column is also disclosed. The method includes providing a seal as described above, compressing the first surface of the seal against an end of the inlet assembly, positioning the column in fluid communication with the aperture, and engaging the column with the second surface.Type: GrantFiled: October 21, 2005Date of Patent: June 10, 2008Assignee: Agilent Technologies, Inc.Inventors: William James Emmons, Wesley Miles Norman, Matthew S. Klee
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Patent number: 7287441Abstract: The invention provides a low mass and size thermal focusing device for a gas phase analytical device. The device has two or more plates bonded together. The device also has at least one channel with an entrance and exit is formed within allowing ingress and egress of a gas stream. The device also has a temperature reduction module in thermal contact with at least one plate of the device. Thermal focusing devices with additional plates and/or channels are also disclosed.Type: GrantFiled: November 8, 2005Date of Patent: October 30, 2007Assignee: Agilent Technologies, Inc.Inventors: Matthew S. Klee, Wesley Norman
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Patent number: 6966212Abstract: The invention provides a low mass and size thermal focusing device for a gas phase analytical device. The device has two or more plates bonded together. The device also has at least one channel with an entrance and exit is formed within allowing ingress and egress of a gas stream. The device also has a temperature reduction module in thermal contact with at least one plate of the device. Thermal focusing devices with additional plates and/or channels are also disclosed.Type: GrantFiled: April 8, 2004Date of Patent: November 22, 2005Assignee: Agilent Technologies, Inc.Inventors: Matthew S. Klee, Wesley Norman
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Patent number: 6915227Abstract: A data manipulation method to make local chromatography data more usable and comparable to a reference. The method provides time axis correction to better match local data to a reference of the same time scale, time axis transformation to correspond more directly to a reference based on a different time scale, and response axis correction to better match a reference of the same or different response scale, while maintaining the original peak areas. The method may be used along or concurrently with other data manipulation technique to facilitate operations such as searching, matching, visual comparison, mathematical manipulation, and pattern recognition of chromatographic data.Type: GrantFiled: November 26, 2003Date of Patent: July 5, 2005Assignee: Agilent Technologies, Inc.Inventors: Bruce D. Quimby, Matthew S. Klee, Paul C. Dryden, Elmer A. Axelson
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Publication number: 20040122611Abstract: A data manipulation method to make local chromatography data more usable and comparable to a reference. The method provides time axis correction to better match local data to a reference of the same time scale, time axis transformation to correspond more directly to a reference based on a different time scale, and response axis correction to better match a reference of the same or different response scale, while maintaining the original peak areas. The method may be used along or concurrently with other data manipulation technique to facilitate operations such as searching, matching, visual comparison, mathematical manipulation, and pattern recognition of chromatographic data.Type: ApplicationFiled: November 26, 2003Publication date: June 24, 2004Inventors: Bruce D. Quimby, Matthew S. Klee, Paul C. Dryden, Elmer A. Axelson
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Patent number: 6691053Abstract: A data manipulation method to make local chromatography data more usable and comparable to a reference. The method provides time axis correction to better match local data to a reference of the same time scale, time axis transformation to correspond more directly to a reference based on a different time scale, and response axis correction to better match a reference of the same or different response scale, while maintaining the original peak areas. The method may be used along or concurrently with other data manipulation technique to facilitate operations such as searching, matching, visual comparison, mathematical manipulation, and pattern recognition of chromatographic data.Type: GrantFiled: November 30, 2001Date of Patent: February 10, 2004Assignee: Agilent Technologies, Inc.Inventors: Bruce D. Quimby, Matthew S. Klee, Paul C. Dryden, Elmer A. Axelson
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Publication number: 20040005494Abstract: Systems and methods of chemical sensing in fuel cell systems are described. In one aspect, a replaceable sacrificial sensor system includes an input that is configured to be coupled to a fuel stream delivery system, two or more sacrificial chemical sensor fuel cells, and a manifold that is configured to selectively couple the sacrificial chemical sensor fuel cells to the input. In another aspect, a fuel cell system includes a main fuel cell, a fuel stream delivery system that is configured to direct a fuel stream to the main fuel cell, an oxidant stream delivery system that is configured to direct an oxidant stream to the main fuel cell, and a sensor system. The sensor system is coupled to the fuel stream delivery system at a location upstream of the main fuel cell and includes two or more sacrificial chemical sensors and a manifold that is configured to selectively couple the sacrificial chemical sensors to the fuel stream delivery system. A fuel cell monitoring method also is described.Type: ApplicationFiled: July 5, 2002Publication date: January 8, 2004Inventors: Javit A. Drake, William H. Wilson, Matthew S. Klee
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Publication number: 20030110000Abstract: A data manipulation method to make local chromatography data more usable and comparable to a reference. The method provides time axis correction to better match local data to a reference of the same time scale, time axis transformation to correspond more directly to a reference based on a different time scale, and response axis correction to better match a reference of the same or different response scale, while maintaining the original peak areas. The method may be used along or concurrently with other data manipulation technique to facilitate operations such as searching, matching, visual comparison, mathematical manipulation, and pattern recognition of chromatographic data.Type: ApplicationFiled: November 30, 2001Publication date: June 12, 2003Inventors: Bruce D. Quimby, Matthew S. Klee, Paul C. Dryden, Elmer A. Axelson
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Publication number: 20020194898Abstract: A method applies retention-time locking to multidimensional gas chromatography. Retention time locking is applied to both standard and comprehensive multidimensional gas chromatography. Retention time locking may be applied to either or both of the columns in a multidimensional gas chromatography system. Additionally, if the multidimensional system contains more than two columns in series, retention time locking can be applied to any or all of the columns as required.Type: ApplicationFiled: June 25, 2001Publication date: December 26, 2002Inventor: Matthew S. Klee
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Patent number: 6494078Abstract: A method applies retention-time locking to the retention times and/or the column(s) void times of a target analyte(s) being eluted thru a multidimensional gas chromatography system. Retention time locking is applied to both standard and comprehensive multidimensional gas chromatography via the steps of adjusting column(s) head pressure in a locking multidimensional gas chromatograph system such that the measured retention times and/or void times match the known accepted. Retention time locking may be applied to either or both of the columns in a multidimensional gas chromatography system. Additionally, if the multidimensional system contains more than two columns in series, retention time locking can be applied to any or all of the columns as required.Type: GrantFiled: June 25, 2001Date of Patent: December 17, 2002Assignee: Agilent Technologies, Inc.Inventor: Matthew S. Klee
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Patent number: 6493639Abstract: A preferred method for identifying analytes of samples by utilizing chemometric analysis for interpreting chromatographic data obtained under locked conditions includes the steps of: (1) providing a locking GC system which includes a column operated at a column head pressure; (2) adjusting the column head pressure of the locking GC system so that a column void time of the column in the locking GC system, when a known analyte is eluted therethrough, is matched with the column void time of the column in a reference GC system, when the known analyte is eluted therethrough; (3) analyzing the sample with the locking GC system so that chromatographic data corresponding to the sample is compiled, and; (4) performing chemometric analysis on the chromatographic data.Type: GrantFiled: May 16, 2000Date of Patent: December 10, 2002Assignee: Agilent Technologies, Inc.Inventors: Matthew S. Klee, Bruce D. Quimby
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Patent number: 6183635Abstract: Methods of separating and classifying the relative amounts of two or more classes of hydrocarbon molecules in a sample are disclosed wherein an input stream comprising a mobile phase and the sample is injected into a chromatographic column, and an effluent stream exiting a chromatographic column is split into a first effluent stream and a second effluent stream. The mass of carbon in each of the classes of hydrocarbons in the first effluent stream is determined, preferably using a flame ionization detector, and the second effluent stream is directed through a variable restrictor, allowing the pressure and mass flow rate of the input stream to be independently controlled and improved results obtained. In a preferred embodiment the present invention also includes identifying the hydrocarbon molecules in the second effluent stream in order to verify the analysis or provide additional data, preferably by using an ultraviolet detector.Type: GrantFiled: June 7, 1994Date of Patent: February 6, 2001Assignee: Agilent Technologies, Inc.Inventors: Matthew S. Klee, Mu Zou Wang
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Patent number: 6153438Abstract: A method for identifying analytes of interest by referencing to a retention factor database corresponding to a plurality of identified analytes that is independent of column dimensions and carrier gas type while dependent upon stationary phase type ratio and a relative temperature program. The retention factor database is generated on a reference GC system in which the column head pressure is adjusted to ensure high reproducibility of retention times by locking the column void time and/or the retention time of an identified analyte to a specific value such that accurate retention factors (k) can be calculated in accordance with the formula: ##EQU1## where VT is the void time of the column having a specified stationary phase and phase coating installed in a GC system operating in accordance to a specified temperature program (where time is expressed in units of column void time).Type: GrantFiled: May 20, 1997Date of Patent: November 28, 2000Assignee: Hewlett-Packard CompanyInventors: Leonid M. Blumberg, Bruce D. Quimby, Matthew S. Klee
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Patent number: 5987959Abstract: The invention provides a method for automated matching of retention times obtained using a known chromatographic method having a defined set of column parameters and operating parameters to the retention times obtained using a new chromatographic method having a new set of column parameters, wherein the retention times of components separated in accordance with the new chromatographic method are matched to the retention times set forth in the known chromatographic methods. A procedure is described to adjust head pressure to compensate for differences in a new versus the original column, carrier gas, and column outlet pressure of the known method.Type: GrantFiled: March 6, 1998Date of Patent: November 23, 1999Assignee: Hewlett-Packard CompanyInventors: Matthew S. Klee, Bruce D. Quimby, Leonid M. Blumberg
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Patent number: 5827946Abstract: The invention provides a method for developing a retention time database of identified analytes and their respective retention times in a reference Gas Chromatograph (GC) system under locked conditions for identification of unknown analytes of interest eluting from any GC system locked to the retention time database and may also be employed in combination with selective detection and or method translation for enhanced certainty of identification.Type: GrantFiled: April 30, 1997Date of Patent: October 27, 1998Assignee: Hewlett-Packard CompanyInventors: Matthew S. Klee, Philip L. Wylie, Bruce D. Quimby, Leonid M. Blumberg
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Patent number: 5346622Abstract: Methods of separating and classifying the relative amounts of two or more classes of hydrocarbon molecules in a sample are disclosed wherein an input stream comprising a mobile phase and the sample is injected into a chromatographic column, and an effluent stream exiting a chromatographic column is split into a first effluent stream and a second effluent stream. The mass of carbon in each of the classes of hydrocarbons in the first effluent stream is determined, preferably using a flame ionization detector, and the second effluent stream is directed through a variable restrictor, allowing the pressure and mass flow rate of the input stream to be independently controlled and improved results obtained. In a preferred embodiment the present invention also includes identifying the hydrocarbon molecules in the second effluent stream in order to verify the analysis or provide additional data, preferably by using an ultraviolet detector.Type: GrantFiled: March 4, 1993Date of Patent: September 13, 1994Assignee: Hewlett-Packard CompanyInventors: Matthew S. Klee, Mu Z. Wang