Patents by Inventor Matthew S. Sigman

Matthew S. Sigman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods comprising 2-(acylamino)imidazoles
    Patent number: 10493061
    Abstract: The present invention presents 2-(acylamino)imidazoles with therapeutic activity, including selective activity against cancer cells, and compositions comprising them. Methods of using and preparing the 2-(acylamino)imidazoles are also presented.
    Type: Grant
    Filed: September 16, 2016
    Date of Patent: December 3, 2019
    Assignees: Curza Global, LLC, University of Utag Research Foundation
    Inventors: Ryan E. Looper, Rachel M. Vaden, Joseph B. Gibbons, Justin M. Salvant, Anne V. Edwards, Matthew S. Sigman, Bryan E. Welm
  • COMPOSITIONS AND METHODS COMPRISING 2-(ACYLAMINO)IMIDAZOLES
    Publication number: 20170100375
    Abstract: The present invention presents 2-(acylamino)imidazoles with therapeutic activity, including selective activity against cancer cells, and compositions comprising them. Methods of using and preparing the 2-(acylamino)imidazoles are also presented.
    Type: Application
    Filed: September 16, 2016
    Publication date: April 13, 2017
    Inventors: Ryan E. Looper, Rachel M. Vaden, Joseph B. Gibbons, Justin M. Salvant, Anne V. Edwards, Matthew S. Sigman, Bryan E. Welm
  • Alkene hydrofunctionalization reactions
    Patent number: 8088346
    Abstract: A reductive cross coupling reaction process for functionalization of a nucleophilic alkene can be achieved. The nucleophilic alkene and a nucleophilic cross coupling partner compound can be reacted in the presence of an oxidizable alcohol and a suitable catalyst to form a reductive coupling product. Various additives can also be useful to refine the process such as by mitigating certain undesirable intermediates, facilitating specific site selectivity for various substitutions or reaction sites, etc. Chiral additives can be optionally used which act to provide asymmetric catalysis, e.g. allow for regioselective and stereoselective production of reductive coupling products. A reductive cross coupling pathway can include oxidizing the oxidizable alcohol to form a catalyst hydride. The nucleophilic alkene can be inserted into the catalyst hydride to form a catalyst-alkyl intermediate.
    Type: Grant
    Filed: June 25, 2008
    Date of Patent: January 3, 2012
    Assignee: University of Utah Research Foundation
    Inventors: Matthew S. Sigman, Keith M. Gligorich
  • Alkene Hydrofunctionalization Reactions
    Publication number: 20090069580
    Abstract: A reductive cross coupling reaction process for functionalization of a nucleophilic alkene can be achieved. The nucleophilic alkene and a nucleophilic cross coupling partner compound can be reacted in the presence of an oxidizable alcohol and a suitable catalyst to form a reductive coupling product. Various additives can also be useful to refine the process such as by mitigating certain undesirable intermediates, facilitating specific site selectivity for various substitutions or reaction sites, etc. Chiral additives can be optionally used which act to provide asymmetric catalysis, e.g. allow for regioselective and stereoselective production of reductive coupling products. A reductive cross coupling pathway can include oxidizing the oxidizable alcohol to form a catalyst hydride. The nucleophilic alkene can be inserted into the catalyst hydride to form a catalyst-alkyl intermediate.
    Type: Application
    Filed: June 25, 2008
    Publication date: March 12, 2009
    Inventors: Matthew S. Sigman, Keith M. Gligorich
  • Main-group metal-based asymmetric catalysts and applications thereof
    Patent number: 6844448
    Abstract: The present invention relates to a method and catalysts for the stereoselective addition of a nucleophile to a reactive ?-bond of a substrate. The chiral, non-racemic catalysts of the present invention constitute the first examples of catalysts for nucleophilic additions that comprise a main-group metal and a tri- or tetra-dentate ligand.
    Type: Grant
    Filed: December 20, 2002
    Date of Patent: January 18, 2005
    Assignee: President and Fellows of Harvard College
    Inventors: Eric N. Jacobsen, Matthew S. Sigman
  • Parallel combinatorial approach to the discovery and optimization of catalysts and uses thereof
    Publication number: 20040235023
    Abstract: The present invention provides methods and compositions, i.e. synthetic libraries of candidate compounds, useful in the discovery and optimization of compounds which catalyze at least one chemical transformation. In certain instances, the subject compounds catalyze a chemoselective, regioselective, stereoselective or enantioselective transformation.
    Type: Application
    Filed: March 17, 2004
    Publication date: November 25, 2004
    Inventors: Eric N. Jacobsen, Matthew S. Sigman
  • Parallel combinatorial approach to the discovery and optimization of catalysts and uses thereof
    Patent number: 6709824
    Abstract: The present invention provides methods and compositions, i.e. synthetic libraries of candidate compounds, useful in the discovery and optimization of compounds which catalyze at least one chemical transformation. In certain instances, the subject compounds catalyze a chemoselective, regioselective, stereoselective or enantioselective transformation.
    Type: Grant
    Filed: September 24, 2001
    Date of Patent: March 23, 2004
    Assignee: President and Fellows of Harvard College
    Inventors: Eric N. Jacobsen, Matthew S. Sigman
  • Main-group metal-based asymmetric catalysts and applications thereof
    Publication number: 20030187249
    Abstract: The present invention relates to a method and catalysts for the stereoselective addition of a nucleophile to a reactive &pgr;-bond of a substrate. The chiral, non-racemic catalysts of the present invention constitute the first examples of catalysts for nucleophilic additions that comprise a main-group metal and a tri- or tetra-dentate ligand.
    Type: Application
    Filed: December 20, 2002
    Publication date: October 2, 2003
    Inventors: Eric N. Jacobsen, Matthew S. Sigman
  • Main-group metal based asymmetric catalysts and applications thereof
    Patent number: 6521561
    Abstract: The present invention relates to a method and catalysts for the stereoselective addition of a nucleophile to a reactive &pgr;-bond of a substrate. The chiral, non-racemic catalysts of the present invention constitute the first examples of catalysts for nucleophilic additions that comprise a main-group metal and a tri- or tetra-dentate ligand.
    Type: Grant
    Filed: May 1, 1998
    Date of Patent: February 18, 2003
    Assignee: President and Fellows of Harvard College
    Inventors: Eric N. Jacobsen, Matthew S. Sigman
  • Parallel combinatorial approach to the discovery and optimization of catalysts and uses thereof
    Publication number: 20020102612
    Abstract: The present invention provides methods and compositions, i.e. synthetic libraries of candidate compounds, useful in the discovery and optimization of compounds which catalyze at least one chemical transformation. In certain instances, the subject compounds catalyze a chemoselective, regioselective, stereoselective or enantioselective transformation.
    Type: Application
    Filed: September 24, 2001
    Publication date: August 1, 2002
    Inventors: Eric N. Jacobsen, Matthew S. Sigman
  • Parallel combinatorial approach to the discovery and optimization of catalysts and uses thereof
    Patent number: 6316616
    Abstract: The present invention provides methods and compositions, i.e. synthetic libraries of candidate compounds, useful in the discovery and optimization of compounds which catalyze at least one chemical transformation. In certain instances, the subject compounds catalyze a chemoselective, regioselective, stereoselective or enantioselective transformation.
    Type: Grant
    Filed: April 22, 1998
    Date of Patent: November 13, 2001
    Assignee: President and Fellows of Harvard College
    Inventors: Eric N. Jacobsen, Matthew S. Sigman
  • Method for the cyclotrimerization of alkynes in aqueous solutions
    Patent number: 6225500
    Abstract: This invention discloses an improved method for the [2+2+2] cyclotrimerization reaction in aqueous solutions using a water soluble transition metal catalyst.
    Type: Grant
    Filed: March 13, 1997
    Date of Patent: May 1, 2001
    Assignee: Invenux, Inc.
    Inventors: Bruce Eaton, Matthew S. Sigman
  • Method for the cyclotrimerization of alkynes in aqueous solutions
    Patent number: 5760266
    Abstract: This invention discloses an improved method for the ?2+2+2! cyclotrimerization reaction in aqueous solutions using a water soluble transition metal catalyst.
    Type: Grant
    Filed: March 13, 1997
    Date of Patent: June 2, 1998
    Assignee: NeXstar Pharmaceuticals, Inc.
    Inventors: Bruce Eaton, Matthew S. Sigman
  • Method for the cyclotrimerization of alkynes in aqueous solutions
    Patent number: 5659069
    Abstract: This invention discloses an improved method for the [2+2+2] cyclotrimerization reaction in aqueous solutions using a water soluble transition metal catalyst.
    Type: Grant
    Filed: March 20, 1996
    Date of Patent: August 19, 1997
    Assignee: NeXstar Pharmaceuticals, Inc.
    Inventors: Bruce Eaton, Matthew S. Sigman