Patents by Inventor Matthew Scanlan

Matthew Scanlan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cancer-testis antigens
    Publication number: 20060089303
    Abstract: Cancer-testis (CT) antigens have been identified by screening public databases for transcripts that are expressed in tumor tissues and a limited set of normal tissues, or by screening for genes that are expressed in cancer and testis tissues (but not other normal tissues). The invention relates to nucleic acids and encoded polypeptides which are CT antigens expressed in patients afflicted with cancer. The invention provides, inter alia, isolated nucleic acid molecules, expression vectors containing those molecules and host cells transfected with those molecules. The invention also provides isolated proteins and peptides, antibodies to those proteins and peptides and cytotoxic T lymphocytes which recognize the proteins and peptides. Fragments of the foregoing including functional fragments and variants also are provided. Kits containing the foregoing molecules additionally are provided.
    Type: Application
    Filed: September 29, 2005
    Publication date: April 27, 2006
    Applicants: Ludwig Institute for Cancer Research, Cornell Research Foundation, Inc.
    Inventors: Lloyd Old, Matthew Scanlan, Cynthia Scanlan, Yao-Tseng Chen
  • Isolated nucleic acid molecules encoding cancer associated antigens, the antigens per se, and uses thereof
    Patent number: 6911529
    Abstract: The invention relates to newly identified cancer associated antigens. It has been discovered that each of these molecules provokes antibodies when expressed by a subject. The ramifications of this observation are also part of this invention.
    Type: Grant
    Filed: June 22, 2000
    Date of Patent: June 28, 2005
    Assignees: Ludwig Institute for Cancer Research, Cornell Research Foundation, Memorial Sloan-Kettering Cancer Center
    Inventors: Dirk Jager, Elizabeth Stockert, Matthew Scanlan, Ali Gure, Elke Jager, Alexander Knuth, Lloyd Old, Yao-tseng Chen
  • Isolated nucleic acid molecules encoding cancer associated antigens, the antigens per se, and uses thereof
    Publication number: 20050063981
    Abstract: The invention relates to newly identified cancer associated antigens. It has been discovered that each of these molecules provokes antibodies when expressed by a subject. The ramifications of this observation are also a part of this invention.
    Type: Application
    Filed: December 4, 2003
    Publication date: March 24, 2005
    Inventors: Dirk Jager, Elisabeth Stockert, Barry Picker, Matthew Scanlan, Cynthia Scanlan, Ali Gure, Elke Jager, Alexander Knuth, Lloyd Old, Yao-Tseng Chen
  • Isolated nucleic acid molecules which encode peptides which bind to MHC class II molecules, such as HLA-DR53
    Publication number: 20040158044
    Abstract: The invention relates to peptides which bind to MHC Class I and to MHC Class II molecules. These peptides are useful in different therapeutic and diagnostic contexts.
    Type: Application
    Filed: January 2, 2004
    Publication date: August 12, 2004
    Inventors: Alexander Knuth, Elke Jager, Yao-tseng Chen, Matthew Scanlan, Ali Gure, Gerd Ritter, Lloyd J. Old, Jan W. Drijfhout
  • Isolated nucleic acid molecules encoding cancer associated antigens, the antigens per se, and uses thereof
    Patent number: 6774226
    Abstract: The invention relates to newly identified cancer associated antigens. It has been discovered that each of these molecules provokes antibodies when expressed by a subject. The ramifications of this observation are also a part of this invention.
    Type: Grant
    Filed: November 30, 1999
    Date of Patent: August 10, 2004
    Assignees: Ludwig Institute for Cancer Research, Cornell Research Foundation, Inc.
    Inventors: Dirk Jager, Elizabeth Stockert, Matthew Scanlan, Ali Gure, Elke Jager, Alexander Knuth, Lloyd Old, Yao-tseng Chen
  • Isolated nucleic acid molecules encoding cancer associated antigens, the antigens per se, and uses thereof
    Publication number: 20040126398
    Abstract: The invention relates to newly identified cancer associated antigens. It has been discovered that each of these molecules provokes antibodies when expressed by a subject. The ranifications of this observation are also a part of this invention.
    Type: Application
    Filed: February 24, 2003
    Publication date: July 1, 2004
    Inventors: Dirk Jager, Elisabeth Stockert, Matthew Scanlan, Alexander Knuth, Lloyd Old, Ali Gure, Yao-Tseng Chen, Elke Jager
  • Isolated peptides corresponding to amino acid sequences of NY-ESO-1, which bind to MHC Class I and MHC Class II molecules, and uses thereof
    Patent number: 6723832
    Abstract: The invention relates to peptides which bind to MHC Class I and to MHC Class II molecules. These peptides are useful in different therapeutic and diagnostic contexts.
    Type: Grant
    Filed: October 2, 1998
    Date of Patent: April 20, 2004
    Assignees: Ludwig Institute for Cancer Research, Memorial Sloan-Kettering Cancer Center, Academisch Ziekenhuis Leiden, Cornell Research Foundation
    Inventors: Alexander Knuth, Elke Jäger, Yao-tseng Chen, Matthew Scanlan, Ali Gure, Gerd Ritter, Lloyd J. Old, Jan W. Drijfhout
  • Truncated forms of NY-ESO-1 protein
    Patent number: 6525177
    Abstract: The invention relates to antibodies which bind to the cancer associated antigen NY-ESO-1. Both polyclonal and monoclonal antibodies are part of the invention, as are chimeric forms of the antibodies, and binding portions of antibodies. Uses of these antibodies are described. Also described are truncated, recombinant forms of the cancer associated antigen.
    Type: Grant
    Filed: December 29, 2000
    Date of Patent: February 25, 2003
    Assignees: Cornell Research Foundation, Inc., Ludwig Institute for Cancer Research, Sloan-Kettering Cancer Center
    Inventors: Elisabeth Stockert, Elke Jäger, Yao-tseng Chen, Matthew Scanlan, Knuth Alexander, Lloyd J. Old
  • Isolated cancer associated antigens NY-MEL 1 and NY-MEL 3, peptides based thereon, and their uses
    Publication number: 20030017547
    Abstract: The invention relates to isolated, cancer associated antigens, nucleic acid molecules, and various uses thereof.
    Type: Application
    Filed: May 21, 2002
    Publication date: January 23, 2003
    Inventors: Dirk Jager, Elizabeth Stockert, Matthew Scanlan, Ali Gure, Elke Jager, Alexander Knuth, Lloyd Old, Yao-Tseng Chen
  • Isolated nucleic acid molecules encoding ESO-1 peptides and uses thereof
    Publication number: 20020164665
    Abstract: The invention relates to antibodies which bind to the cancer associated antigen NY-ESO-1. Both polyclonal and monoclonal antibodies are part of the invention, as are chimeric forms of the antibodies, and binding portions of antibodies. Uses of these antibodies are described. Also described are truncated, recombinant forms of the cancer associated antigen.
    Type: Application
    Filed: December 17, 2001
    Publication date: November 7, 2002
    Inventors: Elisabeth Stockert, Elke Jager, Yao-Tseng Chen, Matthew Scanlan, Knuth Alexander, Lloyd J. Old
  • Isolated nucleic acid molecules encoding cancer associated antigens, the antigens per se, and uses thereof
    Patent number: 6448073
    Abstract: The invention relates to isolated, cancer associated antigens, nucleic acid molecules, and various uses thereof.
    Type: Grant
    Filed: January 28, 2000
    Date of Patent: September 10, 2002
    Assignee: Ludwig Institute for Cancer Research
    Inventors: Dirk Jager, Elizabeth Stockert, Matthew Scanlan, Ali Gure, Elke Jager, Alexander Knuth, Lloyd Old, Yao-tseng Chen
  • Truncated forms of NY-ESO-1 protein
    Publication number: 20020010321
    Abstract: The invention relates to antibodies which bind to the cancer associated antigen NY-ESO-1. Both polyclonal and monoclonal antibodies are part of the invention, as are chimeric forms of the antibodies, and binding portions of antibodies. Uses of these antibodies are described. Also described are truncated, recombinant forms of the cancer associated antigen.
    Type: Application
    Filed: December 29, 2000
    Publication date: January 24, 2002
    Inventors: Yao-tseng Chen, Matthew Scanlan, Ali O. Gure, Lloyd J. Old, Ozlem Tureci, Ugur Sahin, Michael Pfreundschuh, Elisabeth Stockert, Elke Jager, Knuth Alexander
  • Isolated nucleic acid molecule encoding cancer associated antigen, the antigen itself, and uses thereof
    Patent number: 6274145
    Abstract: The invention relates to the isolation of a nucleic acid molecule which encodes a cancer associated antigen. Also a part of the invention is the antigen itself, and the uses of the nucleic acid molecule and the antigen, and peptides derived from it.
    Type: Grant
    Filed: September 15, 1997
    Date of Patent: August 14, 2001
    Assignee: Ludwig Institute for Cancer Research
    Inventors: Yao-tseng Chen, Matthew Scanlan, Ali Guré, Lloyd J. Old, Elke Jäger, Knuth Alexander, Jan W. Drijfhout, Ozlem Tureci, Ugur Sahin, Michael Pfreundschuh
  • Isolated nucleic acid molecule encoding an esophageal cancer associated antigen
    Patent number: 6255470
    Abstract: The invention relates to the isolation of a nucleic acid molecule which encodes an esophageal cancer associated antigen. Also a part of the invention is the antigen itself, and the uses of the nucleic acid molecule and the antigen.
    Type: Grant
    Filed: September 14, 1999
    Date of Patent: July 3, 2001
    Assignee: Memorial Sloan-Kettering Cancer Center
    Inventors: Yao-tseng Chen, Matthew Scanlan, Ali Gure, Lloyd J. Old
  • Antibodies which bind to NY-ESO-1 cancer associated proteins, and hybridomas which produce these antibodies
    Patent number: 6252052
    Abstract: The invention relates to antibodies which bind to the cancer associated antigen NY-ESO-1. Both polyclonal and monoclonal antibodies are part of the invention, as are chimeric forms of the antibodies, and binding portions of antibodies. Uses of these antibodies are described. Also described are truncated, recombinant forms of the cancer associated antigen.
    Type: Grant
    Filed: April 17, 1998
    Date of Patent: June 26, 2001
    Assignees: Cornell Research Foundation, Inc, Ludwig Institute for Cancer Research, Memorial Sloan-Kettering Cancer Center
    Inventors: Elisabeth Stockert, Elke Jäger, Yao-tseng Chen, Matthew Scanlan, Knuth Alexander, Lloyd J. Old
  • Isolated nucleic acid molecule encoding an esophageal cancer associated antigen, the antigen itself, and uses thereof
    Patent number: 6069233
    Abstract: The invention relates to the isolation of a nucleic acid molecule which encodes an esophageal cancer associated antigen. Also a part of the invention is the antigen itself, and the uses of the nucleic acid molecule and the antigen.
    Type: Grant
    Filed: January 26, 1998
    Date of Patent: May 30, 2000
    Assignees: Memorial Sloan-Kettering Cancer Center, Cornell Research Foundation, Ludwig Institute for Cancer Research
    Inventors: Yao-tseng Chen, Matthew Scanlan, Ali O. Gure, Lloyd J. Old, Ozlem Tureci, Ugur Sahin, Michael Pfreundschuh
  • Isolated nucleic acid molecule encoding an esophageal cancer associated antigen, the antigen itself, and uses thereof
    Patent number: 5804381
    Abstract: The invention relates to the isolation of a nucleic acid molecule which encodes an esophageal cancer associated antigen. Also a part of the invention is the antigen itself, and the uses of the nucleic acid molecule and the antigen.
    Type: Grant
    Filed: October 3, 1996
    Date of Patent: September 8, 1998
    Assignees: Cornell Research Foundation, Ludwig Institute for Cancer Research, Memorial Sloan-Kettering Cancer Center
    Inventors: Yao-tseng Chen, Matthew Scanlan, Ali Gure, Lloyd J. Old