Patents by Inventor Matthew Schaab

Matthew Schaab has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for assessing biospecimen integrity
    Patent number: 10126306
    Abstract: Methods for quantifying biospecimen sample integrity using markers of oxidation (FIG. 1). Under conditions of incomplete blood plasma/serum (P IS) sample freezing (including storage at ?20 ?C), two different forms of oxidation occur spontaneously at protein sulfur atoms—namely S-cysteinylation of free cysteine residues (in which the oxidative event is disulfide bond formation) and sulfoxidation of methionine. Oxidized forms of albumin and apoA-1, SCA and MOA1 are useful markers of biospecimen integrity. The oxidative chemistries of SCA and MOAI are operational in other proteins and polypeptides. Thus, for rare cases in which the use of SCA or MOA1 may be contraindicated, custom designed surrogate peptide probes based on SCA and MOA1 oxidation chemistry may be fortified into samples at collection to serve as exogenous markers of P/S sample integrity.
    Type: Grant
    Filed: February 11, 2015
    Date of Patent: November 13, 2018
    Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
    Inventors: Chad Borges, Matthew Schaab, Douglas Rehder
  • METHODS FOR ASSESSING BIOSPECIMEN INTEGRITY
    Publication number: 20170010278
    Abstract: Methods for quantifying biospecimen sample integrity using markers of oxidation (FIG. 1). Under conditions of incomplete blood plasma/serum (P IS) sample freezing (including storage at ?20 ?C), two different forms of oxidation occur spontaneously at protein sulfur atoms—namely S-cysteinylation of free cysteine residues (in which the oxidative event is disulfide bond formation) and sulfoxidation of methionine. Oxidized forms of albumin and apoA-1, SCA and MOA1 are useful markers of biospecimen integrity. The oxidative chemistries of SCA and MOAI are operational in other proteins and polypeptides. Thus, for rare cases in which the use of SCA or MOA1 may be contraindicated, custom designed surrogate peptide probes based on SCA and MOA1 oxidation chemistry may be fortified into samples at collection to serve as exogenous markers of P/S sample integrity.
    Type: Application
    Filed: February 11, 2015
    Publication date: January 12, 2017
    Applicant: Arizona Board of Regents on behalf of Arizona State University
    Inventors: Chad Borges, Matthew Schaab, Douglas Rehder
  • Buffers for stabilizing biological specimens and their use
    Patent number: 8669111
    Abstract: The present invention provides reagents and methods for limiting adsorptive and/or oxidative protein losses in a sample.
    Type: Grant
    Filed: January 24, 2013
    Date of Patent: March 11, 2014
    Assignee: Arizona Board of Regents, A Body Corporate of the State of Arizona Acting for and on Behalf of Arizona State University
    Inventors: Douglas Rehder, Matthew Schaab, Chad Borges