Abstract: A cuff for providing vagus nerve stimulation to a subject having an esophagus is disclosed. The cuff includes a helical body that is configured to wrap around at least a portion of the esophagus of the subject, the helical body having an inner surface, the inner surface having a length and a width. The inner surface defines an interior space that is configured to receive the esophagus. A first electrode is coupled to the helical body. At least one additional electrode is coupled to the helical body. The at least one additional electrode is configured to provide a polarity opposite of the first electrode.

Abstract: One aspect of the present disclosure relates to a system that can modulate the intensity of a neural stimulation signal over time. A pulse generator can be configured to generate a stimulation signal for application to neural tissue of an individual and modulate a parameter related to intensity of a pattern of pulses of the stimulation signal over time. An electrode can be coupled to the pulse generator and configured to apply the stimulation signal to the neural tissue. A population of axons in the neural tissue can be recruited with each pulse of the stimulation signal.

Abstract: One aspect of the present disclosure relates to a system that can modulate the intensity of a neural stimulation signal over time. A pulse generator can be configured to generate a stimulation signal for application to neural tissue of an individual and modulate a parameter related to intensity of a pattern of pulses of the stimulation signal over time. An electrode can be coupled to the pulse generator and configured to apply the stimulation signal to the neural tissue. A population of axons in the neural tissue can be recruited with each pulse of the stimulation signal.

Abstract: One aspect of the present disclosure relates to a system that can modulate the intensity of a neural stimulation signal over time. A pulse generator can be configured to generate a stimulation signal for application to neural tissue of an individual and modulate a parameter related to intensity of a pattern of pulses of the stimulation signal over time. An electrode can be coupled to the pulse generator and configured to apply the stimulation signal to the neural tissue. A population of axons in the neural tissue can be recruited with each pulse of the stimulation signal.

Abstract: One aspect of the present disclosure relates to a system that can modulate the intensity of a neural stimulation signal over time. A pulse generator can be configured to generate a stimulation signal for application to neural tissue of an individual and modulate a parameter related to intensity of a pattern of pulses of the stimulation signal over time. An electrode can be coupled to the pulse generator and configured to apply the stimulation signal to the neural tissue. A population of axons in the neural tissue can be recruited with each pulse of the stimulation signal.

Abstract: One aspect of the present disclosure relates to a system that can modulate the intensity of a neural stimulation signal over time. A pulse generator can be configured to generate a stimulation signal for application to neural tissue of an individual and modulate a parameter related to intensity of a pattern of pulses of the stimulation signal over time. An electrode can be coupled to the pulse generator and configured to apply the stimulation signal to the neural tissue. A population of axons in the neural tissue can be recruited with each pulse of the stimulation signal.

Abstract: One aspect of the present disclosure relates to a system that can modulate the intensity of a neural stimulation signal over time. A pulse generator can be configured to generate a stimulation signal for application to neural tissue of an individual and modulate a parameter related to intensity of a pattern of pulses of the stimulation signal over time. An electrode can be coupled to the pulse generator and configured to apply the stimulation signal to the neural tissue. A population of axons in the neural tissue can be recruited with each pulse of the stimulation signal.

Abstract: One aspect of the present disclosure relates to a system that can modulate the intensity of a neural stimulation signal over time. A pulse generator can be configured to generate a stimulation signal for application to neural tissue of an individual and modulate a parameter related to intensity of a pattern of pulses of the stimulation signal over time. An electrode can be coupled to the pulse generator and configured to apply the stimulation signal to the neural tissue. A population of axons in the neural tissue can be recruited with each pulse of the stimulation signal.

Abstract: One aspect of the present disclosure relates to a system that can modulate the intensity of a neural stimulation signal over time. A pulse generator can be configured to generate a stimulation signal for application to neural tissue of an individual and modulate a parameter related to intensity of a pattern of pulses of the stimulation signal over time. An electrode can be coupled to the pulse generator and configured to apply the stimulation signal to the neural tissue. A population of axons in the neural tissue can be recruited with each pulse of the stimulation signal.

Abstract: One aspect of the present disclosure relates to a system that can modulate the intensity of a neural stimulation signal over time. A pulse generator can be configured to generate a stimulation signal for application to neural tissue of an individual and modulate a parameter related to intensity of a pattern of pulses of the stimulation signal over time. An electrode can be coupled to the pulse generator and configured to apply the stimulation signal to the neural tissue. A population of axons in the neural tissue can be recruited with each pulse of the stimulation signal.

Abstract: One aspect of the present disclosure relates to a system that can modulate the intensity of a neural stimulation signal over time. A pulse generator can be configured to generate a stimulation signal for application to neural tissue of an individual and modulate a parameter related to intensity of a pattern of pulses of the stimulation signal over time. An electrode can be coupled to the pulse generator and configured to apply the stimulation signal to the neural tissue. A population of axons in the neural tissue can be recruited with each pulse of the stimulation signal.

Abstract: One aspect of the present disclosure relates to a system that can modulate the intensity of a neural stimulation signal over time. A pulse generator can be configured to generate a stimulation signal for application to neural tissue of an individual and modulate a parameter related to intensity of a pattern of pulses of the stimulation signal over time. An electrode can be coupled to the pulse generator and configured to apply the stimulation signal to the neural tissue. A population of axons in the neural tissue can be recruited with each pulse of the stimulation signal.

Abstract: One aspect of the present disclosure relates to a system that can modulate the intensity of a neural stimulation signal over time. A pulse generator can be configured to generate a stimulation signal for application to neural tissue of an individual and modulate a parameter related to intensity of a pattern of pulses of the stimulation signal over time. An electrode can be coupled to the pulse generator and configured to apply the stimulation signal to the neural tissue. A population of axons in the neural tissue can be recruited with each pulse of the stimulation signal.

Abstract: An implantable cuff includes an elastic collar, at least one conductive segment disposed on or within the elastic collar, and at least one conductor in electrical communication with the at least one conductive segment. The elastic collar defines an internal opening configured to receive an internal body tissue. At least a portion of the elastic collar includes a stiffening region having a stiffness greater than a second region of the elastic collar. The at least one conductor is configured to operably mate with an apparatus capable of delivering electrical stimulation to, and/or recording an electrical activity of, the internal body tissue.

Abstract: The present invention generally relates to patterned intensity modulation of neural tissue. Certain embodiments provide a method of treating medical conditions by providing an electrode and modulating stimulation parameters delivered by the electrode. The stimulation parameters that are modulated relate to stimulation intensity and are varied according to a stimulation input parameter or time. The stimulation input parameter can be a choice of an individual waveform (i.e. ? or psi), which may be varied for each pulse.

Abstract: The present invention generally relates to patterned intensity modulation of neural tissue. Certain embodiments provide a method of treating medical conditions by providing an electrode and modulating stimulation parameters delivered by the electrode. The stimulation parameters that are modulated relate to stimulation intensity and are varied according to a stimulation input parameter or time. The stimulation input parameter can be a choice of an individual waveform (i.e. ? or psi), which may be varied for each pulse.

Abstract: An implantable cuff includes an elastic collar, at least one conductive segment disposed on or within the elastic collar, and at least one conductor in electrical communication with the at least one conductive segment. The elastic collar defines an internal opening configured to receive an internal body tissue. At least a portion of the elastic collar includes a stiffening region having a stiffness greater than a second region of the elastic collar. The at least one conductor is configured to operably mate with an apparatus capable of delivering electrical stimulation to, and/or recording an electrical activity of, the internal body tissue.

Abstract: A method for selective electrical stimulation of a retina for application in a visual neuralprosthesis. The method includes application of an asymmetrical, charge-balance biphasic waveform to increase the receptivity of selected cells to a subsequent stimulus, and then electrically stimulating to those selected cells to induce either a punctuate phosphene (perceived spot of light in the visual field) or a streak phosphene (streak of light in the visual field). A waveform having a sub-threshold anodic pulse followed by a supra-threshold cathodic pulse induces the punctuate phosphene, and a sub-threshold cathodic pulse followed by a supra-threshold anodic pulse induces the streak phosphene.