Patents by Inventor Matthew Schiel

Matthew Schiel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Faster resistive-pulse sensing together with physical and mechanical characterization of particles and cells
    Patent number: 9658206
    Abstract: A method for multiplex characterization of individual particles by their size, shape, mechanical properties (deformability), and chemical affinity to recognition agents. The analysis can be performed from concentrated solutions. The method detects transient sticking of particles in the pore and points to its location along a pore axis. If a pore is decorated with a recognition agent for an analyte present in a solution, it is possible to distinguish specific binding at the place of the recognition agent, and non-specific adsorption of the analyte. The method confirms whether any individual particle or hydrogel completely translocates the pore and allows unambiguous detection and characterization of multiple particles or hydrogels in the pore, which would previously corrupt the results, so that higher analyte concentrations can be used for faster analysis.
    Type: Grant
    Filed: May 9, 2014
    Date of Patent: May 23, 2017
    Assignee: The Regents of the University of California
    Inventors: Zuzanna S. Siwy, Kenneth J. Shea, Ken Healy, Laura Michele Innes, Matthew Schiel, Matthew Pevarnik
  • FASTER RESISTIVE-PULSE SENSING TOGETHER WITH PHYSICAL AND MECHANICAL CHARACTERIZATION OF PARTICLES AND CELLS
    Publication number: 20140332381
    Abstract: A method for multiplex characterization of individual particles by their size, shape, mechanical properties (deformability), and chemical affinity to recognition agents. The analysis can be performed from concentrated solutions. The method detects transient sticking of particles in the pore and points to its location along a pore axis. If a pore is decorated with a recognition agent for an analyte present in a solution, it is possible to distinguish specific binding at the place of the recognition agent, and non-specific adsorption of the analyte. The method confirms whether any individual particle or hydrogel completely translocates the pore and allows unambiguous detection and characterization of multiple particles or hydrogels in the pore, which would previously corrupt the results, so that higher analyte concentrations can be used for faster analysis.
    Type: Application
    Filed: May 9, 2014
    Publication date: November 13, 2014
    Applicant: The Regents of the University of California
    Inventors: Zuzanna S. Siwy, Kenneth J. Shea, Ken Healy, Laura Michele Innes, Matthew Schiel, Matthew Pevarnik