Abstract: A central routing function (CRF) comprises back-to-back user agent application that receives a request for a call route list from a network element, wherein the request comprises a destination telephone number, a list generation application that obtains the call route list from the prioritized call route lists stored in the non-transitory memory based on the destination telephone number, wherein the call route list comprises a plurality of addresses, a pseudo domain name service (DNS) application that translates each address in the call route list into an Internet Protocol (IP) address, in which the back-to-back user agent application attempts to terminate a call using the IP address in the call route list, and in which the CRF platform is implemented in a software container.

Abstract: Disclosed herein are compositions and methods for isolating DNA, such as cell-free DNA (cfDNA). In some embodiments, the cell-free DNA is from a subject having or suspected of having cancer and/or the cell-free DNA comprises DNA produced by a tumor. In some embodiments, the DNA isolated by the method is captured using a sequence-variable target region set and an epigenetic target region set, wherein the sequence-variable target region set is captured with a greater capture yield than the epigenetic target region set. In some embodiments, captured cfDNA of the sequence-variable target region set is sequenced to a greater depth of sequencing than captured cfDNA of the epigenetic target region set.

Abstract: Systems and methods for targeted advertising to specific consumers are disclosed. A system may include a memory storing instructions; and at least one processor configured to execute the instructions to: receive, over a network, consumer data from a client device; identify a plurality of client-provided consumers from the consumer data; obtain a plurality of unique consumer identifiers corresponding to the plurality of client-provided consumers; and identify at least one first overlapping unique consumer identifier by matching at least one of the plurality of client-provided consumers with at least one publisher-provided consumer provided by a first publisher device of a plurality of publisher devices, the first publisher device having a highest priority among the plurality of publisher devices.

Abstract: Disclosed herein are compositions and methods for isolating DNA, such as cell-free DNA (cfDNA). In some embodiments, the cell-free DNA is from a subject having or suspected of having cancer and/or the cell-free DNA comprises DNA produced by a tumor. In some embodiments, the DNA isolated by the method is captured using a sequence-variable target region set and an epigenetic target region set, wherein the sequence-variable target region set is captured with a greater capture yield than the epigenetic target region set. In some embodiments, captured cfDNA of the sequence-variable target region set is sequenced to a greater depth of sequencing than captured cfDNA of the epigenetic target region set.

Abstract: A system and associated methods for round-the-clock monitoring of an animal's health status includes an animal harness that is worn by the animal, and one or both of a mobile device and a remote server. The animal harness includes a plurality of sensors for collecting health measurements of the animal. The animal harness also includes a transceiver that communicates the heath measurements to one or both of the mobile device and the remote server, where a user may view the health measurements. Firmware in the animal harness, an application running in the mobile device, and software in the remote server processes and corrects the health measurements to generate a health status of the animal and notifications are generated when the animal's health is not within a safe range defined by the user.

Abstract: A system and associated methods use an animal harness attached to an animal to improve security at a location (e.g., a home, office, warehouse, etc.). The animal harness collects health status data of the animal, and the health status data is processed using one or more algorithms that detect changes in one or more of excitement, agitation, stress, and/or anxiety in the animal. These changes are interpreted, using a behavioral model of the animal, to determine whether the animal is witnessing a security event at the location, and when the health status data indicates the security event, the system may generate an alert. The behavioral model may be updated over time to improve performance of the algorithms to detect security events.

Abstract: Systems and methods for targeted advertising to specific consumers are disclosed. A system may include a memory storing instructions; and at least one processor configured to execute the instructions to: receive, over a network, consumer data from a client device; identify a plurality of client-provided consumers from the consumer data; obtain a plurality of unique consumer identifiers corresponding to the plurality of client-provided consumers; and identify at least one first overlapping unique consumer identifier by matching at least one of the plurality of client-provided consumers with at least one publisher-provided consumer provided by a first publisher device of a plurality of publisher devices, the first publisher device having a highest priority among the plurality of publisher devices.

Abstract: A system and associated methods use an animal harness attached to an animal to improve security at a location (e.g., a home, office, warehouse, etc.). The animal harness collects health status data of the animal, and the health status data is processed using one or more algorithms that detect changes in one or more of excitement, agitation, stress, and/or anxiety in the animal. These changes are interpreted, using a behavioral model of the animal, to determine whether the animal is witnessing a security event at the location, and when the health status data indicates the security event, the system may generate an alert. The behavioral model may be updated over time to improve performance of the algorithms to detect security events.

Abstract: Disclosed herein are compositions and methods for isolating DNA, such as cell-free DNA (cfDNA). In some embodiments, the cell-free DNA is from a subject having or suspected of having cancer and/or the cell-free DNA comprises DNA produced by a tumor. In some embodiments, the DNA isolated by the method is captured using a sequence-variable target region set and an epigenetic target region set, wherein the sequence-variable target region set is captured with a greater capture yield than the epigenetic target region set. In some embodiments, captured cfDNA of the sequence-variable target region set is sequenced to a greater depth of sequencing than captured cfDNA of the epigenetic target region set.

Abstract: In an aspect, a method for evaluating the partitioning of nucleic acid molecules in a sample of polynucleotides based on epigenetic state, comprising: (a) adding a set of epigenetic-control nucleic acid molecules to the nucleic acid molecules in the sample of polynucleotides, whereby producing a spiked-in sample; (b) partitioning nucleic acid molecules of the spiked-in sample into plurality of partitioned sets; (c) enriching a subset of molecules from the plurality of partitioned sets to generate enriched molecules, wherein the enriched molecules comprises a group of epigenetic-control nucleic acid molecules and a group of nucleic acid molecules from the sample of polynucleotides; (d) sequencing the enriched molecules to produce sequencing reads; (e) analyzing the sequencing reads to generate one or more epigenetic partition scores of the epigenetic-control nucleic acid molecules; and (f) comparing the one or more epigenetic partition scores with one or more epigenetic partition cut-offs.

Abstract: A system and associated methods for round-the-clock monitoring of an animal's health status includes an animal harness that is worn by the animal, and one or both of a mobile device and a remote server. The animal harness includes a plurality of sensors for collecting health measurements of the animal. The animal harness also includes a transceiver that communicates the heath measurements to one or both of the mobile device and the remote server, where a user may view the health measurements. Firmware in the animal harness, an application running in the mobile device, and software in the remote server processes and corrects the health measurements to generate a health status of the animal and notifications are generated when the animal's health is not within a safe range defined by the user.

Abstract: The disclosure provides methods for processing nucleic acid populations containing different forms (e.g., RNA and DNA, single-stranded or double-stranded) and/or extents of modification (e.g., cytosine methylation, association with proteins). These methods accommodate multiple forms and/or modifications of nucleic acid in a sample, such that sequence information can be obtained for multiple forms. The methods also preserve the identity of multiple forms or modified states through processing and analysis, such that analysis of sequence can be combined with epigenetic analysis.

Abstract: A safety harness and quick connecting lifting sling used by people such as commercial divers that are required to wear some type of helmet or head gear (such as a diving helmet or full face mask) while being lifted wearing the safety harness. The harness is designed with multiple attachment points that are used to quickly connect the lifting sling for lifting the diver in or out of the water. The lifting sling has been specifically designed with one or more net structures that are used to stabilize the head area and support the weight of the head gear (diving helmet or mask) when the diver is lifted to help prevent neck fatigue and/or injuries to the diver, even if the person is unconscious.

Abstract: A selectable detent assembly that has a housing with a plurality of passageways. Within the housing is a selector spool that is disposed within a selector passageway and is rotatable to provide a plurality of rotational positions including a no detent position, a kick down position, and a continuous detent position. A pilot check valve is disposed within the housing and provides a fluid flow path from a pilot passageway to the selector passageway and a detent passageway. A detent arming piston is disposed within the detent passageway and is connected to a directional control valve spool. Thus, depending on the rotational position of the selector spool, the selector spool can either provide a continuous flow path through the selector passageway to a tank, a flow path that is controlled by the axial position of the selector spool or prevent flow to the tank in order to operate the detent arming piston.

Abstract: A knowledge Management (KM) tool that allows persons in an organization to more rapidly locate the people and information they need to answer their questions. Identification and visualization of information aggregate founders, including category creators, helps in locating expertise, and additionally helps to reveal and magnify hidden knowledge dynamics within the organization.

Abstract: A tubular body is operatively coupled to an oral nasal mask and provided with lateral apertures adapted for fluid flow. A flexible valve is mounted onto one end of the tubular body and adapted to seal the lateral apertures under normal operation conditions and expose the lateral apertures for fluid flow during emergency operation conditions. The sealed lateral apertures keep exhaust gases from escaping the oral nasal mask and contaminating the interior of the diving equipment during normal operation conditions. The exposed lateral apertures allow air from an alternate source to reach the mouth and nose of a user covered by the oral nasal mask during emergency operation conditions. The exposed lateral apertures allow excess water to be removed from inside the diving equipment. The valve system may be implemented as an integrated regulator mount nut/valve system.

Abstract: A selectable detent assembly that has a housing with a plurality of passageways. Within the housing is a selector spool that is disposed within a selector passageway and is rotatable to provide a plurality of rotational positions including a no detent position, a kick down position, and a continuous detent position. A pilot check valve is disposed within the housing and provides a fluid flow path from a pilot passageway to the selector passageway and a detent passageway. A detent arming piston is disposed within the detent passageway and is connected to a directional control valve spool. Thus, depending on the rotational position of the selector spool, the selector spool can either provide a continuous flow path through the selector passageway to a tank, a flow path that is controlled by the axial position of the selector spool or prevent flow to the tank in order to operate the detent arming piston.

Abstract: A system and method for evaluating an information aggregate. A metrics database stores document indicia including document attributes and associated person. A query engine responsive to a user request and the metrics database aggregates documents having same, unique attributes in a plurality of information aggregates, and determines the intersections of said information aggregates. A visualization engine displays these intersections selectively with reference to people, documents, usage patterns or categories.