Patents by Inventor Matthew Seavey

Matthew Seavey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions comprising angiogenic factors and methods of use thereof
    Patent number: 10695410
    Abstract: The present invention provides recombinant Listeria strains comprising an angiogenic factor, recombinant polypeptides comprising an angiogenic factor operatively linked to a polypeptide comprising a PEST-like sequence, recombinant nucleotide molecules encoding same, related vaccines, and immunogenic and therapeutic methods utilizing same.
    Type: Grant
    Filed: May 28, 2018
    Date of Patent: June 30, 2020
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Matthew Seavey, Yvonne Paterson, Paulo Maciag, Duane Sewell
  • COMPOSITIONS COMPRISING ANGIOGENIC FACTORS AND METHODS OF USE THEREOF
    Publication number: 20190117750
    Abstract: The present invention provides recombinant Listeria strains comprising an angiogenic factor, recombinant polypeptides comprising an angiogenic factor operatively linked to a polypeptide comprising a PEST-like sequence, recombinant nucleotide molecules encoding same, related vaccines, and immunogenic and therapeutic methods utilizing same.
    Type: Application
    Filed: May 28, 2018
    Publication date: April 25, 2019
    Inventors: Matthew SEAVEY, Yvonne PATERSON, Paulo MACIAG, Duane SEWELL
  • Compositions comprising angiogenic factors and methods of use thereof
    Patent number: 9981024
    Abstract: The present invention provides recombinant Listeria strains comprising an angiogenic factor, recombinant polypeptides comprising an angiogenic factor operatively linked to a polypeptide comprising a PEST-like sequence, recombinant nucleotide molecules encoding same, related vaccines, and immunogenic and therapeutic methods utilizing same.
    Type: Grant
    Filed: August 1, 2016
    Date of Patent: May 29, 2018
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Matthew Seavey, Yvonne Paterson, Paulo Maciag, Duane Sewell
  • Compositions comprising angiogenic factors and methods of use thereof
    Patent number: 9919038
    Abstract: The present invention provides recombinant Listeria strains comprising an angiogenic factor, recombinant polypeptides comprising an angiogenic factor operatively linked to a polypeptide comprising a PEST-like sequence, recombinant nucleotide molecules encoding same, related vaccines, and immunogenic and therapeutic methods utilizing same.
    Type: Grant
    Filed: January 15, 2016
    Date of Patent: March 20, 2018
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Matthew Seavey, Yvonne Paterson, Paulo Maciag, Duane Sewell
  • COMPOSITIONS COMPRISING ANGIOGENIC FACTORS AND METHODS OF USE THEREOF
    Publication number: 20170049867
    Abstract: The present invention provides recombinant Listeria strains comprising an angiogenic factor, recombinant polypeptides comprising an angiogenic factor operatively linked to a polypeptide comprising a PEST-like sequence, recombinant nucleotide molecules encoding same, related vaccines, and immunogenic and therapeutic methods utilizing same.
    Type: Application
    Filed: August 1, 2016
    Publication date: February 23, 2017
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Matthew SEAVEY, Yvonne Paterson, Paulo Maciag, Duane Sewell
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF HER2/NEU OVER-EXPRESSING TUMORS
    Publication number: 20160361401
    Abstract: This invention provides compositions and methods for treating and vaccinating against a HER2/neu antigen-expressing tumor and inducing an immune response against the same in a subject.
    Type: Application
    Filed: February 25, 2015
    Publication date: December 15, 2016
    Inventors: Vafa Shahabi, Anu Wallecha, Paulo C. Maciag, Yvonne Paterson, Nicola Mason, Matthew Seavey
  • Compositions comprising angiogenic factors and methods of use thereof
    Patent number: 9408898
    Abstract: The present invention provides recombinant Listeria strains comprising an angiogenic factor, recombinant polypeptides comprising an angiogenic factor operatively linked to a polypeptide comprising a PEST-like sequence, recombinant nucleotide molecules encoding same, related vaccines, and immunogenic and therapeutic methods utilizing same.
    Type: Grant
    Filed: June 13, 2014
    Date of Patent: August 9, 2016
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Matthew Seavey, Yvonne Paterson, Paulo Maciag, Duane Sewell
  • COMPOSITIONS COMPRISING ANGIOGENIC FACTORS AND METHODS OF USE THEREOF
    Publication number: 20160206716
    Abstract: The present invention provides recombinant Listeria strains comprising an angiogenic factor, recombinant polypeptides comprising an angiogenic factor operatively linked to a polypeptide comprising a PEST-like sequence, recombinant nucleotide molecules encoding same, related vaccines, and immunogenic and therapeutic methods utilizing same.
    Type: Application
    Filed: January 15, 2016
    Publication date: July 21, 2016
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: Matthew Seavey, Yvonne Paterson, Paulo Maciag, Duane Sewell
  • COMPOSITIONS AND METHODS FOR PREVENTION OF ESCAPE MUTATION IN THE TREATMENT OF HER2/NEU OVER-EXPRESSING TUMORS
    Publication number: 20150297702
    Abstract: This invention provides compositions and methods for treating and vaccinating against a Her2/neu antigen-expressing tumor and inducing an immune response against dominant in a human subject.
    Type: Application
    Filed: July 1, 2015
    Publication date: October 22, 2015
    Inventors: VAFA SHAHABI, ANU WALLECHA, PAULO C. MACIAG, YVONNE PATERSON, MATTHEW SEAVEY, NICOLA MASON
  • Compositions and methods for prevention of escape mutation in the treatment of HER2/NEU over-expressing tumors
    Patent number: 9084747
    Abstract: This invention provides compositions and methods for treating and vaccinating against an Her2/neu antigen-expressing tumor and inducing an immune response against dominant and several sub-dominant epitopes of the antigen.
    Type: Grant
    Filed: November 12, 2010
    Date of Patent: July 21, 2015
    Assignees: Advaxis, Inc., The Trustees Of The University Of Pennsylvania
    Inventors: Vafa Shahabi, Anu Wallecha, Paulo C. Maciag, Yvonne Paterson, Matthew Seavey
  • Compositions and methods for prevention of escape mutation in the treatment of Her2/neu over-expressing tumors
    Patent number: 9017660
    Abstract: This invention provides compositions and methods for treating and vaccinating against an Her2/neu antigen-expressing tumor and inducing an immune response against dominant in a non-human animal.
    Type: Grant
    Filed: August 16, 2011
    Date of Patent: April 28, 2015
    Assignees: Advaxis, Inc., The Trustees of the University of Pennsylvania
    Inventors: Vafa Shahabi, Anu Wallecha, Paulo C. Maciag, Yvonne Paterson, Nicola Mason, Matthew Seavey
  • COMPOSITIONS COMPRISING ANGIOGENIC FACTORS AND METHODS OF USE THEREOF
    Publication number: 20150079034
    Abstract: The present invention provides recombinant Listeria strains comprising an angiogenic factor, recombinant polypeptides comprising an angiogenic factor operatively linked to a polypeptide comprising a PEST-like sequence, recombinant nucleotide molecules encoding same, related vaccines, and immunogenic and therapeutic methods utilizing same.
    Type: Application
    Filed: June 13, 2014
    Publication date: March 19, 2015
    Inventors: Matthew SEAVEY, Yvonne Paterson, Paulo Maciag, Duane Sewell
  • Compositions comprising angiogenic factors and methods of use thereof
    Patent number: 8778329
    Abstract: The present invention provides recombinant Listeria strains comprising an angiogenic factor, recombinant polypeptides comprising an angiogenic factor operatively linked to a polypeptide comprising a PEST-like sequence, recombinant nucleotide molecules encoding same, related vaccines, and immunogenic and therapeutic methods utilizing same.
    Type: Grant
    Filed: March 4, 2010
    Date of Patent: July 15, 2014
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Matthew Seavey, Yvonne Paterson, Paulo Maciag, Duane Sewell
  • Compositions comprising HMW-MAA and fragments thereof, and methods of use thereof
    Patent number: 8268326
    Abstract: This invention provides recombinant polypeptides comprising a fragment of a High Molecular Weight Melanoma-Associated Antigen (HMW-MAA), recombinant Listeria strains comprising same, and methods of inducing an anti-HMW-MAA and anti HER-2/neu immune response thus treating and impeding the growth of tumors, comprising administering same.
    Type: Grant
    Filed: October 3, 2008
    Date of Patent: September 18, 2012
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Yvonne Paterson, Paulo Maciag, Matthew Seavey, Soldano Ferrone
  • COMPOSITIONS COMPRISING ANGIOGENIC FACTORS AND METHODS OF USE THEREOF
    Publication number: 20120114685
    Abstract: The present invention provides recombinant Listeria strains comprising an angiogenic factor, recombinant polypeptides comprising an angiogenic factor operatively linked to a polypeptide comprising a PEST-like sequence, recombinant nucleotide molecules encoding same, related vaccines, and immunogenic and therapeutic methods utilizing same.
    Type: Application
    Filed: March 4, 2010
    Publication date: May 10, 2012
    Inventors: Matthew Seavey, Yvonne Paterson, Paulo Maciag, Duane Sewell, Catherine Sewell
  • LIVE LISTERIA-BASED VACCINES FOR CENTRAL NERVOUS SYSTEM THERAPY
    Publication number: 20110223187
    Abstract: This invention is directed to methods for treating a central nervous system (CNS) tumor or cancer using live Listeria-based recombinant vaccines.
    Type: Application
    Filed: February 15, 2011
    Publication date: September 15, 2011
    Inventors: Vafa SHAHABI, Matthew Seavey, Yvonne Paterson
  • COMPOSITIONS COMPRISING HMW-MAA AND FRAGMENTS THEREOF, AND METHODS OF USE THEREOF
    Publication number: 20090202587
    Abstract: This invention provides recombinant polypeptides comprising a fragment of a High Molecular Weight Melanoma-Associated Antigen (HMW-MAA), recombinant Listeria strains comprising same, and methods of inducing an anti-HMW-MAA and anti HER-2/neu immune response thus treating and impeding the growth of tumors, comprising administering same.
    Type: Application
    Filed: October 3, 2008
    Publication date: August 13, 2009
    Inventors: Yvonne PATERSON, Paulo Maciag, Matthew Seavey, Soldano Ferrone