Abstract: The present invention relates to compounds of formula I: in which p, q, Y1, Y2, R1, R2a, R2b, R3a, R3b, R4a, R4b, R5a, R5b, R7 and R8 are defined in the Summary of the Invention; capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with the aberrant activity of SHP2.

Abstract: The unitary center support bearing subassembly comprises a bearing over which a plastic bearing housing has been molded while simultaneously molding the plastic bracket insert and joining members which space and fix the distance between the bearing housing and the bracket insert. The joining members are removed or broken prior to molding the overmolded rubber portion, or, if the joining member is flexible, the overmolded rubber portion is molded while maintaining the joining member.

Abstract: A bearing arrangement for a shaft (1) in a sleeve (2) which concentrically surrounds said shaft (1) should preferably be used for a water pump, with the bearing arrangement having two cylindrical roller or needle rings (3) which roll directly on the inner periphery of the sleeve (2) and on the outer periphery of the shaft (1). Arranged between said two cylindrical roller or needle rings (3) is a ball ring which rolls in a running groove (13) on the sleeve (2) and a running groove (14) on the shaft (1). The spherical rolling bodies (12) of said ball ring (11) form, together with the running grooves (13 and 14) of the sleeve (2) and of the shaft (1), a four-point bearing.