Abstract: A pharmaceutical product for administration of an anti TROP2 antibody-drug conjugate in combination with an ATR inhibitor is provided. The anti-TROP2 antibody-drug conjugate is an antibody-drug conjugate in which a drug linker represented by the following formula (wherein A represents the connecting position to an anti-TROP2 antibody) is conjugated to an anti-TROP2 antibody via a thioether bond. Also provided is a therapeutic use and method wherein the anti-TROP2 antibody-drug conjugate and the ATR inhibitor are administered in combination to a subject: Formula (I).

Abstract: A pharmaceutical product for administration of an anti-TROP2 antibody-drug conjugate in combination with a PARP1 selective inhibitor is provided. The anti-TROP2 antibody-drug conjugate is an antibody-drug conjugate in which a drug-linker represented by the following formula (wherein A represents the connecting position to an anti-TROP2 antibody) is conjugated to an anti-TROP2 antibody via a thioether bond.

Abstract: A cargo transport includes a chassis, a plurality of wheels configured to support the chassis, a cargo box supported by the chassis, and a rear frame coupled to a rear end of the cargo box. The rear frame includes a header, a rear bolster disposed below the header, and a pair of opposed vertical frame members extending between the rear bolster and the header. The header is positioned at least partially above a roof of the cargo box and includes a plurality of openings configured to induce turbulence within airflow at the rear end of the cargo box.

Abstract: A coupler assembly for a trailer includes a base plate, a king pin assembly coupled to the base plate, the king pin assembly configured to be coupled to a fifth wheel of a tractor, and a support frame coupled to the base plate and configured to brace the king pin assembly. The support frame includes a pair of outboard reinforcement members forming an obtuse included angle therebetween, and a pair of inboard reinforcement members forming an acute included angle therebetween. The pair of inboard reinforcement members are disposed within the obtuse angle formed by the pair of outboard reinforcement members. The obtuse angle formed by the pair of outboard reinforcement members and the acute angle formed by the pair of inboard reinforcement members are each bisected by a longitudinal axis of the trailer.

Abstract: A technique includes providing at least one service blueprint to orchestrate application programming interfaces to manage the lifecycle of at least one cloud service.

Abstract: In one aspect, a method includes receiving, by a content-management system and from a content-presentation device, a request for supplemental content, such as a replacement advertisement. The content-management system may then determine a technical characteristic of the content-presentation device and select supplemental content based at least in part on at least the determined technical characteristic of the content-presentation device. The content-management system may then cause the selected supplemental content to be transmitted to the content-presentation device to facilitate the content-presentation device performing a content modification operation.

Abstract: A technique includes providing at least one service blueprint to orchestrate application programming interfaces to manage the lifecycle of at least one cloud service.

Abstract: A king pin coupler assembly of a fifth wheel coupling. A coupler plate has a king pin aperture therein. A king pin is positioned to extend axially through the king pin aperture of the coupler plate. The king pin has a first portion with a neck for engaging a fifth wheel of the fifth wheel coupling, the first portion extending to a first side of the coupler plate. The king pin has a second portion on a second side of the coupler plate and welded to the coupler plate. A shielding apparatus is secured to one or both of the king pin and the coupler plate. The shielding apparatus includes a cover sealed to the first side of the coupler plate. The cover extends over the first portion of the king pin to shield the first portion of the king pin during liquid immersion of the king pin coupler assembly.

Abstract: In one aspect, a method includes receiving first content at a content-presentation device and presenting the first content, the first content comprising a first audio-content component. The content-presentation device may receive second content comprising a second audio-content component. The content-presentation device may determine a switch time at which to switch from presenting the first content to presenting the second content. During a first time interval prior to the switch time and ending at the switch time, the volume of the first audio-content component may be decreased to zero. At the switch time, the content-presentation device may switch from presenting the first content to presenting the second content. During a second time interval beginning at the switch time and ending at a second time after the switch time, the volume of the second audio-content component may be increased from zero to a non-zero volume level.

Abstract: Disclosed herein are compositions and methods for detecting RNA binding sites and RNA interacting partners involving the use of a modified capture oligonucleotide having a dual toehold design.

Abstract: In one aspect, a method includes receiving, by a content-management system and from a content-presentation device, a request for supplemental content, such as a replacement advertisement. The content-management system may then determine a technical characteristic of the content-presentation device and select supplemental content based at least in part on at least the determined technical characteristic of the content-presentation device. The content-management system may then cause the selected supplemental content to be transmitted to the content-presentation device to facilitate the content-presentation device performing a content modification operation.

Abstract: In one aspect, a method includes receiving, by a content-management system and from a content-presentation device, a request for supplemental content, such as a replacement advertisement. The content-management system may then determine a technical characteristic of the content-presentation device and select supplemental content based at least in part on at least the determined technical characteristic of the content-presentation device. The content-management system may then cause the selected supplemental content to be transmitted to the content-presentation device to facilitate the content-presentation device performing a content modification operation.

Abstract: In one aspect, a method includes receiving first content at a content-presentation device and presenting the first content, the first content comprising a first audio-content component. The content-presentation device may receive second content comprising a second audio-content component. The content-presentation device may determine a switch time at which to switch from presenting the first content to presenting the second content. During a first time interval prior to the switch time and ending at the switch time, the volume of the first audio-content component may be decreased to zero. At the switch time, the content-presentation device may switch from presenting the first content to presenting the second content. During a second time interval beginning at the switch time and ending at a second time after the switch time, the volume of the second audio-content component may be increased from zero to a non-zero volume level.

Abstract: Described herein is an inkjet ink composition for printing conductive traces. The inkjet ink composition comprises: polymer-capped metal nanoparticles; a first hydroxy compound, which is a monohydroxyl-substituted hydrocarbon comprising 1 to 6 carbon atoms; a second hydroxy compound, which is selected from a polyol, a monohydric ether and mixtures thereof; and water; wherein the weight ratio of water to first hydroxyl compound is in the range of 1:0.5 to 1:1.5; and wherein the weight ratio of water to second hydroxy compound is in the range of 1:0.5 to 1:1.5. Also described herein are a method of producing the inkjet ink composition and a method of printing conductive traces.

Abstract: A king pin coupler assembly of a fifth wheel coupling. A coupler plate has a king pin aperture therein. A king pin is positioned to extend axially through the king pin aperture of the coupler plate. The king pin has a first portion with a neck for engaging a fifth wheel of the fifth wheel coupling, the first portion extending to a first side of the coupler plate. The king pin has a second portion on a second side of the coupler plate and welded to the coupler plate. A shielding apparatus is secured to one or both of the king pin and the coupler plate. The shielding apparatus includes a cover sealed to the first side of the coupler plate. The cover extends over the first portion of the king pin to shield the first portion of the king pin during liquid immersion of the king pin coupler assembly.

Abstract: In one aspect, a method includes receiving first content at a content-presentation device and presenting the first content, the first content comprising a first audio-content component. The content-presentation device may receive second content comprising a second audio-content component. The content-presentation device may determine a switch time at which to switch from presenting the first content to presenting the second content. During a first time interval prior to the switch time and ending at the switch time, the volume of the first audio-content component may be decreased to zero. At the switch time, the content-presentation device may switch from presenting the first content to presenting the second content. During a second time interval beginning at the switch time and ending at a second time after the switch time, the volume of the second audio-content component may be increased from zero to a non-zero volume level.

Abstract: The invention provides methods and compositions for generating mutations in new nucleic acid molecules through incorporation of a transformable nucleoside into the nucleic acid and subsequent transformation of the nucleoside through oxidative-nucleophilic-aromatic-substitution chemistry, referred to as TimeLapse chemistry. The invention further provides methods for detecting the mutations, referred to as TimeLapse-seq.

Abstract: A king pin coupler assembly of a fifth wheel coupling. A coupler plate has a king pin aperture therein. A king pin is positioned to extend axially through the king pin aperture of the coupler plate. The king pin has a first portion with a neck for engaging a fifth wheel of the fifth wheel coupling, the first portion extending to a first side of the coupler plate. The king pin has a second portion on a second side of the coupler plate and welded to the coupler plate. A shielding apparatus is secured to one or both of the king pin and the coupler plate. The shielding apparatus includes a cover sealed to the first side of the coupler plate. The cover extends over the first portion of the king pin to shield the first portion of the king pin during liquid immersion of the king pin coupler assembly.

Abstract: A technique includes providing at least one service blueprint to orchestrate application programming interfaces to manage the lifecycle of at least one cloud service.

Abstract: A technique includes providing at least one service blueprint to orchestrate application programming interfaces to manage the lifecycle of at least one cloud service.