Abstract: Disclosed are chimeric antigen receptors (CARs) comprising Centyrins (i.e. CARTyrins), transposons encoding CARs and CARTyrins of the disclosure, cells modified to express CARs and CARTyrins of the disclosure, as well as methods of making and methods of using same for adoptive cell therapy.

Abstract: The present invention relates to improved light bar cover for LED light bars. The presently disclosed light bar covers may cover the full circumference and length of a light bar and may include a multi-functional tool for easing the installation or removal. While installed, the light bar cover protects the light bar from various damages such as debris or the elements. The multi-function tool may be used to assist in the removal and installation of the cover when mounted in hard to access location. In various embodiments the multi-function tool may be used to deploy the cover, provide rigidity to the cover, and/or actuate a fastener for the cover.

Abstract: The present invention relates to improved light bar cover for LED light bars. The presently disclosed light bar covers may cover the full circumference and length of a light bar and may include a multi-functional tool for easing the installation or removal. While installed, the light bar cover protects the light bar from various damages such as debris or the elements. The multi-function tool may be used to assist in the removal and installation of the cover when mounted in hard to access location. In various embodiments the multi-function tool may be used to deploy the cover, provide rigidity to the cover, and/or actuate a fastener for the cover.

Abstract: The present disclosure relates to a terahertz imaging system for imaging a lumen of a human, such as an intravascular space. A system may include a catheter and a terahertz transceiver device coupled to the catheter. The terahertz transceiver device may be operative to output terahertz radiation through a lumen of a human and to receive reflection signals based on the terahertz radiation. A power source may be coupled to the terahertz transceiver device. The system may further include a controller in communication with the terahertz transceiver device. The controller is operative to obtain an image of the lumen based on the reflection signals.

Abstract: This invention relates to use of the compound N-[(R)-2,3-dihydroxy-propoxy]-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide for treating abnormal cell growth in mammals. In particular, the invention provides dosage regimes for administration of N-[(R)-2,3-dihydroxy-propoxy]-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide to mammals suffering from cancer.

Abstract: The present invention relates to methods involving the selection of peptides from complex displayed libraries to induce or detect signal transduction pathway activation. In one embodiment, the present invention provides methods for the selection of peptides capable of binding a viable cell and subsequently triggering or detecting programmed cell death (e.g., apoptosis). The present invention also provides compositions comprising the selected peptides suitable for medicinal and research use.

Abstract: The present invention relates to herpes simplex virus (HSV) amplicon vectors, and in particular, HSV-1 amplicon vectors, which have been genetically modified and used alone or with consequent genetically modified HSV virus, to target a selected cell type, such as neoplastic cells. The present invention also relates to methods of using such vectors to target a cell, in order to treat a pathologic condition, such as cancer.

Abstract: A fiber optic fiber Fabry-Perot interferometer diaphragm sensor and method of measurement is provided. A fiber Fabry-Perot interferometer diaphragm sensor (12a, 12b, 12c) includes a base (54a, 54b, 54c) and a diaphragm (52a, 52b, 52c) with an optic fiber (30) coupled under tension between the base (54a, 54b, 54c) and the diaphragm (52a, 52b, 52c). A fiber Fabry-Perot interferometer element (40) is contained within the optic fiber (30) and operates to sense movement of the diaphragm (52a, 52b, 52c). In a particular embodiment, the diaphragm (52a) moves in response to a pressure (P) applied to the diaphragm (52a). In another embodiment, a proof mass (72) is coupled to the diaphragm (52b) such that the diaphragm (52b) moves in response to an acceleration (A). In yet another embodiment, a magnetic body (80) is coupled to the diaphragm (52c) such that the diaphragm (52c) moves in response to a magnetic field (M).