Patents by Inventor Matthew Spock

Matthew Spock has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTAGONISTS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4
    Publication number: 20240109873
    Abstract: Disclosed herein are compounds of formula (III) useful as antagonists of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating neurodegenerative disorders using the compounds and compositions.
    Type: Application
    Filed: December 22, 2021
    Publication date: April 4, 2024
    Inventors: Aaron M. Bender, Matthew Spock, Melissa A. Korkmaz-Vaisys, Cori A. Malinky, P. Jeffrey Conn, Craig W. Lindsley
  • ANTAGONISTS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4
    Publication number: 20240083907
    Abstract: Disclosed herein are substituted hexahydro-1H-cyclopenta[c]pyrrole compounds, which may be useful as antagonists of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating disorders using the compounds and compositions.
    Type: Application
    Filed: October 2, 2020
    Publication date: March 14, 2024
    Inventors: Craig W. Lindsley, P. Jeffrey Conn, Aaron M. Bender, Matthew Spock, Changho Han
  • ANTAGONISTS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4
    Publication number: 20240010640
    Abstract: Disclosed herein are 6-((octahydrocyclopenta[c]pyrrol-5-yl)amino)pyridazin-3-yl-substituted pyridinones, pyrimidinones, and pyridazinones, useful as antagonists of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating disorders using the compounds and compositions.
    Type: Application
    Filed: November 18, 2021
    Publication date: January 11, 2024
    Inventors: Aaron M. Bender, Matthew Spock, Melissa A. Korkmaz-Vaisys, Craig W. Lindsley, P. Jeffrey Conn
  • ANTAGONISTS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4
    Publication number: 20230322799
    Abstract: Disclosed herein are 1,2,3,4-tetrahydroisoquinolines and 4, 5, 6, 7-tetrahydrothieno [2, 3-cjpyridines, useful as antagonists of the muscarinic acetylcholine receptor M4 (mA·Ch·RM4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating disorders using the compounds and compositions.
    Type: Application
    Filed: August 13, 2021
    Publication date: October 12, 2023
    Inventors: Aaron M. Bender, Matthew Spock, P. Jeffrey Conn, Craig W. Lindsley
  • CONDENSED SUBSTITUTED HYDROPYRROLES AS ANTAGONISTS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4
    Publication number: 20230183219
    Abstract: Disclosed herein are substituted hexahydro-1//-cyclopenta[c]pyrrole compounds, which may be useful as antagonists of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating disorders using the compounds and compositions.
    Type: Application
    Filed: April 23, 2021
    Publication date: June 15, 2023
    Inventors: Craig W. Lindsley, P. Jeffrey Conn, Darren W. Engers, Aaron M. Bender, Changho Han, Trever R. Carter, Matthew Spock
  • ANTAGONISTS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4
    Publication number: 20230150986
    Abstract: Disclosed herein are 2,3,5-trifluorophenyl-pyridazine substituted hexahydro-1H-cyclopenta[c]pyrrole compounds, useful as antagonists of the muscarinic acetylcholine receptor M4 (mAChR M4) Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating disorders using the compounds and compositions.
    Type: Application
    Filed: December 10, 2020
    Publication date: May 18, 2023
    Inventors: Craig W. Lindsley, P. Jeffrey Conn, Aaron M. Bender, Katrina A. Bollinger, Trever R. Carter, Jerri M. Rook, Jonathan W. Dickerson, Julie L. Engers, Kayla J. Temple, Changho Han, Matthew Spock, Logan A. Baker, Thomas M. Bridges
  • ANTAGONISTS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4
    Publication number: 20230122344
    Abstract: Disclosed herein are substituted hexahydro-1H-cyclopenta[c]pyrrole compounds, which may be useful as antagonists of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating disorders using the compounds and compositions.
    Type: Application
    Filed: December 10, 2020
    Publication date: April 20, 2023
    Inventors: Craig W. Lindsley, P. Jeffrey Conn, Aaron M. Bender, Matthew Spock, Changho Han