Patents by Inventor Matthew Stremlau

Matthew Stremlau has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TREATMENT OF VIRAL INFECTIONS WITH COMBINATION OF PIKFYVE KINASE INHIBITORS AND TMPRSS-2 INHIBITORS
    Publication number: 20210338683
    Abstract: The present invention relates to methods of treating viral infections including COVID-19 and compositions with a combination of (i) an inhibitor of phosphatidylinositol-3-phosphate 5-kinase (PIKfyve) and (ii) an inhibitor of transmembrane serine proteinase 2 (TMPRSS-2).
    Type: Application
    Filed: May 3, 2021
    Publication date: November 4, 2021
    Inventors: Justin K. Ichida, Matthew Stremlau, Hongyan Zhou
  • Methods and compositions for the treatment and prevention of HIV infection using TRIM5?
    Patent number: 8309697
    Abstract: The invention provides novel TRIM polypeptides, proteins, and nucleic acid molecules. In addition to isolated, full-length TRIM proteins, the invention further provides isolated TRIM fusion proteins, antigenic peptides and anti-TRIM antibodies. The invention also provides TRIM nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which an TRIM gene has been introduced or disrupted. The present invention also provides methods and compositions for the diagnosis and treatment of viral infection and/or replication, e.g., HIV infection. The invention further provides methods for identifying a compound capable of treating or preventing viral infection and/or replication, e.g., HIV infection and AIDS. In addition, the invention provides a method for treating a subject having a viral infection and/or replication, e.g.
    Type: Grant
    Filed: January 19, 2010
    Date of Patent: November 13, 2012
    Assignee: Dana-Farber Cancer Institute, Inc.
    Inventors: Joseph Sodroski, Matthew Stremlau, Christopher M. Owens
  • Methods and Compositions for the Treatment and Prevention of HIV Infection Using TRIM5ALPHA
    Publication number: 20100129438
    Abstract: The invention provides novel TRIM polypeptides, proteins, and nucleic acid molecules. In addition to isolated, full-length TRIM proteins, the invention further provides isolated TRIM fusion proteins, antigenic peptides and anti-TRIM antibodies. The invention also provides TRIM nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which an TRIM gene has been introduced or disrupted. The present invention also provides methods and compositions for the diagnosis and treatment of viral infection and/or replication, e.g., HIV infection. The invention further provides methods for identifying a compound capable of treating or preventing viral infection and/or replication, e.g., HIV infection and AIDS. In addition, the invention provides a method for treating a subject having a viral infection and/or replication, e.g.
    Type: Application
    Filed: January 19, 2010
    Publication date: May 27, 2010
    Applicant: Dana-Farber Cancer Institute, Inc.
    Inventors: Joseph Sodroski, Matthew Stremlau, Christopher M. Owens
  • Methods and compositions for the treatment and prevention of HIV infection using TRIM5?
    Patent number: 7659382
    Abstract: The invention provides novel TRIM polypeptides, proteins, and nucleic acid molecules. In addition to isolated, full-length TRIM proteins, the invention further provides isolated TRIM fusion proteins, antigenic peptides and anti-TRIM antibodies. The invention also provides TRIM nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which an TRIM gene has been introduced or disrupted. The present invention also provides methods and compositions for the diagnosis and treatment of viral infection and/or replication, e.g., HIV infection. The invention further provides methods for identifying a compound capable of treating or preventing viral infection and/or replication, e.g., HIV infection and AIDS. In addition, the invention provides a method for treating a subject having a viral infection and/or replication, e.g.
    Type: Grant
    Filed: August 25, 2006
    Date of Patent: February 9, 2010
    Assignee: Dana-Farber Cancer Institute, Inc.
    Inventors: Joseph Sodroski, Matthew Stremlau, Christopher M. Owens
  • Methods and compositions for the treatment and prevention of HIV infection using TRIM5alpha
    Publication number: 20070141679
    Abstract: The invention provides novel TRIM polypeptides, proteins, and nucleic acid molecules. In addition to isolated, full-length TRIM proteins, the invention further provides isolated TRIM fusion proteins, antigenic peptides and anti-TRIM antibodies. The invention also provides TRIM nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which an TRIM gene has been introduced or disrupted. The present invention also provides methods and compositions for the diagnosis and treatment of viral infection and/or replication, e.g., HIV infection. The invention further provides methods for identifying a compound capable of treating or preventing viral infection and/or replication, e.g., HIV infection and AIDS. In addition, the invention provides a method for treating a subject having a viral infection and/or replication, e.g.
    Type: Application
    Filed: August 25, 2006
    Publication date: June 21, 2007
    Applicant: Dana-Farber Cancer Institute, Inc.
    Inventors: Joseph Sodroski, Matthew Stremlau, Christopher Owens