Abstract: Provided herein are methods for design of engineered polypeptides that recapitulate molecular structure features of a predetermined portion of several reference protein structures, e.g., related antibody epitopes or protein binding sites. A Machine Learning (ML) model may be used to generate engineered polypeptides. After substituting target residues for corresponding residues in other reference structures in the same scaffold, the scaffolds with each set of target residues may be filtered by structural comparison to identify generalized scaffolds. Generalized scaffolds may be improved by screening libraries of polypeptides.

Abstract: A catch for attachment to an elongated member and to control movement of the elongated member. The catch generally includes a body with one or more channels, a locking member positioned in the body in proximity to the channel, and a release member to control an extent of movement of the locking member. The catch provides for attachment to the elongated member to adjust its length. The catch is adjustable to provide for movement of the elongated member through the channel.

Abstract: A catch for attachment to an elongated member and to control movement of the elongated member. The catch generally includes a body with one or more channels, a locking member positioned in the body in proximity to the channel, and a release member to control an extent of movement of the locking member. The catch provides for attachment to the elongated member to adjust its length. The catch is adjustable to provide for movement of the elongated member through the channel.