Patents by Inventor Matthew T. Holden

Matthew T. Holden has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240011941
    Abstract: The present disclosure discloses a polymer synthesis and assembly chip that includes a semiconductor integrated circuit device that contains a plurality of pixels, wherein each pixel of the plurality of pixels contains an electrode; and wherein a set of pixels of the plurality of pixels is capable of synthesizing a polymer; and wherein a set of pixels of the plurality of pixels is capable of assembling a synthesized polymer, either independently or in concert with one or more pixels of the plurality of pixels; and control circuitry capable of applying voltages to the electrode. The present disclosure includes related methods of use, such as methods for error correction, for use with the described polymer synthesis and assembly chip.
    Type: Application
    Filed: June 9, 2022
    Publication date: January 11, 2024
    Inventors: Matthew T. HOLDEN, Barry MERRIMAN, Ryan DE RIDDER, Kyle T. GUSTAFSON, Michael HELLER
  • Publication number: 20230332140
    Abstract: Described herein are approaches allowing the storing of data at lower densities and increased write speeds. Indexing and recording of data may be separated into separate processes. Rapid DNA extension reactions can then be performed at many distinct locations throughout a solid support, so that the write speed is limited by the ability of the instrumentation to perform spatial addressing operations, rather than chemical synthesis steps.
    Type: Application
    Filed: August 25, 2021
    Publication date: October 19, 2023
    Inventors: Matthew T. HOLDEN, J. William EFCAVITCH
  • Publication number: 20230321625
    Abstract: Systems and methods for polynucleotide synthesis utilize electrochemical deprotection and novel redox chemistries compatible with advanced CMOS nodes, for highly reliable and massively scalable parallel construction of polynucleotide segments having a desired sequence or sequences. Via use of these exemplary techniques, low-cost and large-scale polynucleotide synthesis is facilitated, for example for data storage and retrieval applications.
    Type: Application
    Filed: February 16, 2023
    Publication date: October 12, 2023
    Inventors: Barry Merriman, Ryan de Ridder, Matthew T. Holden, Tim Geiser
  • Patent number: 11724244
    Abstract: Systems and methods for polynucleotide synthesis utilize electrochemical deprotection and novel redox chemistries compatible with advanced CMOS nodes, for highly reliable and massively scalable parallel construction of polynucleotide segments having a desired sequence or sequences. Via use of these exemplary techniques, low-cost and large-scale polynucleotide synthesis is facilitated, for example for data storage and retrieval applications.
    Type: Grant
    Filed: April 13, 2022
    Date of Patent: August 15, 2023
    Assignee: Avery Digital Data, Inc.
    Inventors: Barry Merriman, Ryan de Ridder, Matthew T. Holden, Tim Geiser
  • Publication number: 20230103381
    Abstract: The invention provides improved methods for synthesizing polynucleotides, such as DNA and RNA, using renewable initiators coupled to a solid support. Using the methods of the invention, specific sequences of polynucleotides can be synthesized de novo, base by base, in an aqueous environment, without the use of a nucleic acid template.
    Type: Application
    Filed: May 16, 2022
    Publication date: April 6, 2023
    Inventors: J. William Efcavitch, Matthew T. Holden
  • Patent number: 11612873
    Abstract: Nucleic acid memory strands encoding digital data using a sequence of homopolymer tracts of repeated nucleotides provides a cheaper and faster alternative to conventional digital DNA storage techniques. The use of homopolymer tracts allows for lower fidelity, high throughput sequencing techniques such as nanopore sequencing to read data encoded in the memory strands. Specialized synthesis techniques allow for synthesis of long memory strands capable of encoding large volumes of data despite the reduced data density afforded by homopolymer tracts as compared to conventional single nucleotide sequences.
    Type: Grant
    Filed: April 24, 2019
    Date of Patent: March 28, 2023
    Assignee: Molecular Assemblies, Inc.
    Inventors: J. William Efcavitch, Sanjay Agarwalla, Kim Albizati, Alan W. Grubbs, Matthew T. Holden, Patrycja A. Hopkins, Jay K. Singh
  • Publication number: 20220280906
    Abstract: Systems and methods for polynucleotide synthesis utilize electrochemical deprotection and novel redox chemistries compatible with advanced CMOS nodes, for highly reliable and massively scalable parallel construction of polynucleotide segments having a desired sequence or sequences. Via use of these exemplary techniques, low-cost and large-scale polynucleotide synthesis is facilitated, for example for data storage and retrieval applications.
    Type: Application
    Filed: April 13, 2022
    Publication date: September 8, 2022
    Applicant: Avery Digital Data, Inc.
    Inventors: Barry Merriman, Ryan de Ridder, Matthew T. Holden, Tim Geiser
  • Patent number: 11331643
    Abstract: The invention provides improved methods for synthesizing polynucleotides, such as DNA and RNA, using renewable initiators coupled to a solid support. Using the methods of the invention, specific sequences of polynucleotides can be synthesized de novo, base by base, in an aqueous environment, without the use of a nucleic acid template.
    Type: Grant
    Filed: January 29, 2019
    Date of Patent: May 17, 2022
    Assignee: Molecular Assemblies, Inc.
    Inventors: J. William Efcavitch, Matthew T. Holden
  • Patent number: 11174512
    Abstract: Nucleic acid memory strands encoding digital data using a sequence of homopolymer tracts of repeated nucleotides provides a cheaper and faster alternative to conventional digital DNA storage techniques. The use of homopolymer tracts allows for lower fidelity, high throughput sequencing techniques such as nanopore sequencing to read data encoded in the memory strands. Specialized synthesis techniques allow for synthesis of long memory strands capable of encoding large volumes of data despite the reduced data density afforded by homopolymer tracts as compared to conventional single nucleotide sequences.
    Type: Grant
    Filed: August 21, 2018
    Date of Patent: November 16, 2021
    Assignee: Molecular Assemblies, Inc.
    Inventors: J. William Efcavitch, Matthew T. Holden
  • Patent number: 10982276
    Abstract: Nucleic acid memory strands encoding digital data using a sequence of homopolymer tracts of repeated nucleotides provides a cheaper and faster alternative to conventional digital DNA storage techniques. The use of homopolymer tracts allows for lower fidelity, high throughput sequencing techniques such as nanopore sequencing to read data encoded in the memory strands. Specialized synthesis techniques allow for synthesis of long memory strands capable of encoding large volumes of data despite the reduced data density afforded by homopolymer tracts as compared to conventional single nucleotide sequences.
    Type: Grant
    Filed: May 31, 2018
    Date of Patent: April 20, 2021
    Assignee: Molecular Assemblies, Inc.
    Inventors: J. William Efcavitch, Matthew T. Holden
  • Publication number: 20190344239
    Abstract: Nucleic acid memory strands encoding digital data using a sequence of homopolymer tracts of repeated nucleotides provides a cheaper and faster alternative to conventional digital DNA storage techniques. The use of homopolymer tracts allows for lower fidelity, high throughput sequencing techniques such as nanopore sequencing to read data encoded in the memory strands. Specialized synthesis techniques allow for synthesis of long memory strands capable of encoding large volumes of data despite the reduced data density afforded by homopolymer tracts as compared to conventional single nucleotide sequences.
    Type: Application
    Filed: April 24, 2019
    Publication date: November 14, 2019
    Inventors: J. William Efcavitch, Sanjay Agarwalla, Kim Albizati, Alan W. Grubbs, Matthew T. Holden, Patrycja A. Hopkins, Jay K. Singh
  • Publication number: 20190275492
    Abstract: The invention provides improved methods for synthesizing polynucleotides, such as DNA and RNA, using renewable initiators coupled to a solid support. Using the methods of the invention, specific sequences of polynucleotides can be synthesized de novo, base by base, in an aqueous environment, without the use of a nucleic acid template.
    Type: Application
    Filed: January 29, 2019
    Publication date: September 12, 2019
    Inventors: J. William Efcavitch, Matthew T. Holden
  • Publication number: 20190194739
    Abstract: Nucleic acid memory strands encoding digital data using a sequence of homopolymer tracts of repeated nucleotides provides a cheaper and faster alternative to conventional digital DNA storage techniques. The use of homopolymer tracts allows for lower fidelity, high throughput sequencing techniques such as nanopore sequencing to read data encoded in the memory strands. Specialized synthesis techniques allow for synthesis of long memory strands capable of encoding large volumes of data despite the reduced data density afforded by homopolymer tracts as compared to conventional single nucleotide sequences.
    Type: Application
    Filed: August 21, 2018
    Publication date: June 27, 2019
    Inventors: J. William Efcavitch, Matthew T. Holden
  • Publication number: 20190060860
    Abstract: Described is a method of synthesizing nucleic acids on polyester substrates and the resulting compositions of matter. The method synthesizes nucleic acids from surface hydroxyl initiation points present on the substrate surface. These surface hydroxyls are present either naturally, or as a result of a chemical treatment to cleave ester bonds on the substrate surface. The preferred polyester substrate contains PET.
    Type: Application
    Filed: August 28, 2018
    Publication date: February 28, 2019
    Inventors: Matthew T. Holden, Matthew C.D. Carter, Lloyd M. Smith, David M. Lynn
  • Publication number: 20190040459
    Abstract: Nucleic acid memory strands encoding digital data using a sequence of homopolymer tracts of repeated nucleotides provides a cheaper and faster alternative to conventional digital DNA storage techniques. The use of homopolymer tracts allows for lower fidelity, high throughput sequencing techniques such as nanopore sequencing to read data encoded in the memory strands. Specialized synthesis techniques allow for synthesis of long memory strands capable of encoding large volumes of data despite the reduced data density afforded by homopolymer tracts as compared to conventional single nucleotide sequences.
    Type: Application
    Filed: May 31, 2018
    Publication date: February 7, 2019
    Inventors: J. William Efcavitch, Matthew T. Holden