Patents by Inventor Matthew T. Holden
Matthew T. Holden has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12379344Abstract: The present disclosure discloses a polymer synthesis and assembly chip that includes a semiconductor integrated circuit device that contains a plurality of pixels, wherein each pixel of the plurality of pixels contains an electrode; and wherein a set of pixels of the plurality of pixels is capable of synthesizing a polymer; and wherein a set of pixels of the plurality of pixels is capable of assembling a synthesized polymer, either independently or in concert with one or more pixels of the plurality of pixels; and control circuitry capable of applying voltages to the electrode. The present disclosure includes related methods of use, such as methods for error correction, for use with the described polymer synthesis and assembly chip.Type: GrantFiled: June 9, 2022Date of Patent: August 5, 2025Assignee: Avery Digital Data, Inc.Inventors: Matthew T. Holden, Barry Merriman, Ryan De Ridder, Kyle T. Gustafson, Michael Heller
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Patent number: 12168211Abstract: The invention provides improved methods for synthesizing polynucleotides, such as DNA and RNA, using renewable initiators coupled to a solid support. Using the methods of the invention, specific sequences of polynucleotides can be synthesized de novo, base by base, in an aqueous environment, without the use of a nucleic acid template.Type: GrantFiled: May 16, 2022Date of Patent: December 17, 2024Assignee: Molecular Assemblies, Inc.Inventors: J. William Efcavitch, Matthew T. Holden
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Publication number: 20240011941Abstract: The present disclosure discloses a polymer synthesis and assembly chip that includes a semiconductor integrated circuit device that contains a plurality of pixels, wherein each pixel of the plurality of pixels contains an electrode; and wherein a set of pixels of the plurality of pixels is capable of synthesizing a polymer; and wherein a set of pixels of the plurality of pixels is capable of assembling a synthesized polymer, either independently or in concert with one or more pixels of the plurality of pixels; and control circuitry capable of applying voltages to the electrode. The present disclosure includes related methods of use, such as methods for error correction, for use with the described polymer synthesis and assembly chip.Type: ApplicationFiled: June 9, 2022Publication date: January 11, 2024Inventors: Matthew T. HOLDEN, Barry MERRIMAN, Ryan DE RIDDER, Kyle T. GUSTAFSON, Michael HELLER
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Publication number: 20230332140Abstract: Described herein are approaches allowing the storing of data at lower densities and increased write speeds. Indexing and recording of data may be separated into separate processes. Rapid DNA extension reactions can then be performed at many distinct locations throughout a solid support, so that the write speed is limited by the ability of the instrumentation to perform spatial addressing operations, rather than chemical synthesis steps.Type: ApplicationFiled: August 25, 2021Publication date: October 19, 2023Inventors: Matthew T. HOLDEN, J. William EFCAVITCH
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Publication number: 20230321625Abstract: Systems and methods for polynucleotide synthesis utilize electrochemical deprotection and novel redox chemistries compatible with advanced CMOS nodes, for highly reliable and massively scalable parallel construction of polynucleotide segments having a desired sequence or sequences. Via use of these exemplary techniques, low-cost and large-scale polynucleotide synthesis is facilitated, for example for data storage and retrieval applications.Type: ApplicationFiled: February 16, 2023Publication date: October 12, 2023Inventors: Barry Merriman, Ryan de Ridder, Matthew T. Holden, Tim Geiser
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Patent number: 11724244Abstract: Systems and methods for polynucleotide synthesis utilize electrochemical deprotection and novel redox chemistries compatible with advanced CMOS nodes, for highly reliable and massively scalable parallel construction of polynucleotide segments having a desired sequence or sequences. Via use of these exemplary techniques, low-cost and large-scale polynucleotide synthesis is facilitated, for example for data storage and retrieval applications.Type: GrantFiled: April 13, 2022Date of Patent: August 15, 2023Assignee: Avery Digital Data, Inc.Inventors: Barry Merriman, Ryan de Ridder, Matthew T. Holden, Tim Geiser
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Publication number: 20230103381Abstract: The invention provides improved methods for synthesizing polynucleotides, such as DNA and RNA, using renewable initiators coupled to a solid support. Using the methods of the invention, specific sequences of polynucleotides can be synthesized de novo, base by base, in an aqueous environment, without the use of a nucleic acid template.Type: ApplicationFiled: May 16, 2022Publication date: April 6, 2023Inventors: J. William Efcavitch, Matthew T. Holden
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Patent number: 11612873Abstract: Nucleic acid memory strands encoding digital data using a sequence of homopolymer tracts of repeated nucleotides provides a cheaper and faster alternative to conventional digital DNA storage techniques. The use of homopolymer tracts allows for lower fidelity, high throughput sequencing techniques such as nanopore sequencing to read data encoded in the memory strands. Specialized synthesis techniques allow for synthesis of long memory strands capable of encoding large volumes of data despite the reduced data density afforded by homopolymer tracts as compared to conventional single nucleotide sequences.Type: GrantFiled: April 24, 2019Date of Patent: March 28, 2023Assignee: Molecular Assemblies, Inc.Inventors: J. William Efcavitch, Sanjay Agarwalla, Kim Albizati, Alan W. Grubbs, Matthew T. Holden, Patrycja A. Hopkins, Jay K. Singh
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Publication number: 20220280906Abstract: Systems and methods for polynucleotide synthesis utilize electrochemical deprotection and novel redox chemistries compatible with advanced CMOS nodes, for highly reliable and massively scalable parallel construction of polynucleotide segments having a desired sequence or sequences. Via use of these exemplary techniques, low-cost and large-scale polynucleotide synthesis is facilitated, for example for data storage and retrieval applications.Type: ApplicationFiled: April 13, 2022Publication date: September 8, 2022Applicant: Avery Digital Data, Inc.Inventors: Barry Merriman, Ryan de Ridder, Matthew T. Holden, Tim Geiser
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Patent number: 11331643Abstract: The invention provides improved methods for synthesizing polynucleotides, such as DNA and RNA, using renewable initiators coupled to a solid support. Using the methods of the invention, specific sequences of polynucleotides can be synthesized de novo, base by base, in an aqueous environment, without the use of a nucleic acid template.Type: GrantFiled: January 29, 2019Date of Patent: May 17, 2022Assignee: Molecular Assemblies, Inc.Inventors: J. William Efcavitch, Matthew T. Holden
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Patent number: 11174512Abstract: Nucleic acid memory strands encoding digital data using a sequence of homopolymer tracts of repeated nucleotides provides a cheaper and faster alternative to conventional digital DNA storage techniques. The use of homopolymer tracts allows for lower fidelity, high throughput sequencing techniques such as nanopore sequencing to read data encoded in the memory strands. Specialized synthesis techniques allow for synthesis of long memory strands capable of encoding large volumes of data despite the reduced data density afforded by homopolymer tracts as compared to conventional single nucleotide sequences.Type: GrantFiled: August 21, 2018Date of Patent: November 16, 2021Assignee: Molecular Assemblies, Inc.Inventors: J. William Efcavitch, Matthew T. Holden
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Patent number: 10982276Abstract: Nucleic acid memory strands encoding digital data using a sequence of homopolymer tracts of repeated nucleotides provides a cheaper and faster alternative to conventional digital DNA storage techniques. The use of homopolymer tracts allows for lower fidelity, high throughput sequencing techniques such as nanopore sequencing to read data encoded in the memory strands. Specialized synthesis techniques allow for synthesis of long memory strands capable of encoding large volumes of data despite the reduced data density afforded by homopolymer tracts as compared to conventional single nucleotide sequences.Type: GrantFiled: May 31, 2018Date of Patent: April 20, 2021Assignee: Molecular Assemblies, Inc.Inventors: J. William Efcavitch, Matthew T. Holden
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Publication number: 20190344239Abstract: Nucleic acid memory strands encoding digital data using a sequence of homopolymer tracts of repeated nucleotides provides a cheaper and faster alternative to conventional digital DNA storage techniques. The use of homopolymer tracts allows for lower fidelity, high throughput sequencing techniques such as nanopore sequencing to read data encoded in the memory strands. Specialized synthesis techniques allow for synthesis of long memory strands capable of encoding large volumes of data despite the reduced data density afforded by homopolymer tracts as compared to conventional single nucleotide sequences.Type: ApplicationFiled: April 24, 2019Publication date: November 14, 2019Inventors: J. William Efcavitch, Sanjay Agarwalla, Kim Albizati, Alan W. Grubbs, Matthew T. Holden, Patrycja A. Hopkins, Jay K. Singh
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Publication number: 20190275492Abstract: The invention provides improved methods for synthesizing polynucleotides, such as DNA and RNA, using renewable initiators coupled to a solid support. Using the methods of the invention, specific sequences of polynucleotides can be synthesized de novo, base by base, in an aqueous environment, without the use of a nucleic acid template.Type: ApplicationFiled: January 29, 2019Publication date: September 12, 2019Inventors: J. William Efcavitch, Matthew T. Holden
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Publication number: 20190194739Abstract: Nucleic acid memory strands encoding digital data using a sequence of homopolymer tracts of repeated nucleotides provides a cheaper and faster alternative to conventional digital DNA storage techniques. The use of homopolymer tracts allows for lower fidelity, high throughput sequencing techniques such as nanopore sequencing to read data encoded in the memory strands. Specialized synthesis techniques allow for synthesis of long memory strands capable of encoding large volumes of data despite the reduced data density afforded by homopolymer tracts as compared to conventional single nucleotide sequences.Type: ApplicationFiled: August 21, 2018Publication date: June 27, 2019Inventors: J. William Efcavitch, Matthew T. Holden
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Publication number: 20190060860Abstract: Described is a method of synthesizing nucleic acids on polyester substrates and the resulting compositions of matter. The method synthesizes nucleic acids from surface hydroxyl initiation points present on the substrate surface. These surface hydroxyls are present either naturally, or as a result of a chemical treatment to cleave ester bonds on the substrate surface. The preferred polyester substrate contains PET.Type: ApplicationFiled: August 28, 2018Publication date: February 28, 2019Inventors: Matthew T. Holden, Matthew C.D. Carter, Lloyd M. Smith, David M. Lynn
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Publication number: 20190040459Abstract: Nucleic acid memory strands encoding digital data using a sequence of homopolymer tracts of repeated nucleotides provides a cheaper and faster alternative to conventional digital DNA storage techniques. The use of homopolymer tracts allows for lower fidelity, high throughput sequencing techniques such as nanopore sequencing to read data encoded in the memory strands. Specialized synthesis techniques allow for synthesis of long memory strands capable of encoding large volumes of data despite the reduced data density afforded by homopolymer tracts as compared to conventional single nucleotide sequences.Type: ApplicationFiled: May 31, 2018Publication date: February 7, 2019Inventors: J. William Efcavitch, Matthew T. Holden