Abstract: A fluid drug delivery system that includes an actuator connected to a valve for releasing a pressurized treatment fluid. A fluid chamber can be included that is configured to include the pressurized treatment fluid and include a volume that changes in response to the release of the pressurized treatment fluid. An external pressure interface can be in fluid communication with the fluid chamber. A pressure sensor-display dial can be included operatively connected to the fluid chamber and the external pressure interface to monitor fluid pressure of the fluid chamber and direct the operator to the correct pressure application.

Abstract: A tissue ablation device includes an ablation stem insertable into the working channel of a medical device such as endoscope for radiofrequency ablation of target tissue. The stem includes a sheath, cannula, and ablation wire concentrically disposed within one another. Each of the sheath, cannula and ablation wire are independently controllable by a dedicated positioner located in the handset. An end effector of tines is removably attached to the distal end of the ablation wire and expand radially outwardly when deployed to form a three-dimensional ablation zone. A motor provides repetitive reciprocating vibrations to generate axial displacement of the ablation wire and tines for increased accuracy in insertion into tissue. RF ablation is also provided through the ablation wire and tines. The end effector tines are removable to remain in the target tissue as a fiducial marker for later procedures.