Abstract: Systems and methods are described for optical processing. According to some aspects an optical processing apparatus may include a pixelated photodiode array (PDA), each pixel in the PDA includes a radiation detector. The apparatus also includes a read out integrated circuit (ROIC) that includes a logic circuit and a plurality of switch elements. The plurality of switch elements being switchable between an armed state for arming its corresponding radiation detector and transmitting a signal received from the corresponding detector to the ROIC, and a disarmed state for disarming its corresponding detector and blocking transmittal of the signal, wherein in the armed state, the PDA is configured to detect an incoming optical signal and in the disarmed state, the PDA is configured to disregard the incoming optical signal. Moreover, the logic circuit controls a switch state of a selectable switch element associated with a radiation detector.

Abstract: Systems and methods are described for optical processing. According to some aspects an optical processing apparatus may include a pixelated photodiode array (PDA), each pixel in the PDA includes a radiation detector. The apparatus also includes a read out integrated circuit (ROIC) that includes a logic circuit and a plurality of switch elements. The plurality of switch elements being switchable between an armed state for arming its corresponding radiation detector and transmitting a signal received from the corresponding detector to the ROIC, and a disarmed state for disarming its corresponding detector and blocking transmittal of the signal, wherein in the armed state, the PDA is configured to detect an incoming optical signal and in the disarmed state, the PDA is configured to disregard the incoming optical signal. Moreover, the logic circuit controls a switch state of a selectable switch element associated with a radiation detector.

Abstract: An apparatus includes a pixelated photodiode array (PDA). Each pixel in the PDA includes a radiation detector, a memory configured to store a negative bias voltage for the PDA and a nominal breakdown voltage for each pixel in the PDA, and a read out integrated circuit (ROIC) communicatively coupled to the PDA and the memory. The ROIC is configured to read, from the memory, the negative bias voltage for the PDA and the nominal breakdown voltage for each pixel in the PDA, determine a difference between the negative bias voltage for the PDA and the nominal breakdown voltage for each pixel in the PDA, and adjust an arm/disarm bias voltage for each pixel in the PDA based on the difference between the negative bias voltage for the PDA and the nominal breakdown voltage for each pixel in the PDA.

Abstract: Systems and methods are described for optical processing. According to some aspects an apparatus may include a pixelated photodiode array (PDA), wherein each pixel in the PDA includes a radiation detector. The optical processing apparatus may also include a memory that stores one or more characteristics for each pixel in the PDA, and a read out integrated circuit (ROIC) communicatively coupled to the FPA and the memory. In some aspects, the ROIC reads from the memory the one or more characteristics for each pixel in the PDA, and adjusts an arm/disarm bias voltage for each pixel in the PDA based on the one or more characteristics of each pixel.

Abstract: Systems and methods are described for optical processing. According to some aspects an optical processing apparatus may include a pixelated photodiode array (PDA), each pixel in the PDA includes a radiation detector. The apparatus also includes a read out integrated circuit (ROIC) that includes a logic circuit and a plurality of switch elements. The plurality of switch elements being switchable between an armed state for arming its corresponding radiation detector and transmitting a signal received from the corresponding detector to the ROIC, and a disarmed state for disarming its corresponding detector and blocking transmittal of the signal, wherein in the armed state, the PDA is configured to detect an incoming optical signal and in the disarmed state, the PDA is configured to disregard the incoming optical signal. Moreover, the logic circuit controls a switch state of a selectable switch element associated with a radiation detector.

Abstract: Systems and methods are described for optical processing. According to some aspects an apparatus may include a pixelated photodiode array (PDA), wherein each pixel in the PDA includes a radiation detector. The optical processing apparatus may also include a memory that stores one or more characteristics for each pixel in the PDA, and a read out integrated circuit (ROIC) communicatively coupled to the FPA and the memory. In some aspects, the ROIC reads from the memory the one or more characteristics for each pixel in the PDA, and adjusts an arm/disarm bias voltage for each pixel in the PDA based on the one or more characteristics of each pixel.

Abstract: Disclosed herein are apparatuses and methods for conducting multiple simultaneous micro-volume chemical and biochemical reactions in an array format. In one embodiment, the format comprises an array of microholes in a substrate. Besides serving as an ordered array of sample chambers allowing the performance of multiple parallel reactions, the arrays can be used for reagent storage and transfer, library display, reagent synthesis, assembly of multiple identical reactions, dilution and desalting. Use of the arrays facilitates optical analysis of reactions, and allows optical analysis to be conducted in real time. Included within the invention are kits comprising a microhole apparatus and a reaction component of the method(s) to be carried out in the apparatus.

Abstract: Disclosed herein are apparatuses and methods for conducting multiple simultaneous micro-volume chemical and biochemical reactions in an array format. In one embodiment, the format comprises an array of microholes in a substrate. Besides serving as an ordered array of sample chambers allowing the performance of multiple parallel reactions, the arrays can be used for reagent storage and transfer, library display, reagent synthesis, assembly of multiple identical reactions, dilution and desalting. Use of the arrays facilitates optical analysis of reactions, and allows optical analysis to be conducted in real time. Included within the invention are kits comprising a microhole apparatus and a reaction component of the method(s) to be carried out in the apparatus.

Abstract: Disclosed herein are apparatuses and methods for conducting multiple simultaneous micro-volume chemical and biochemical reactions in an array format. In one embodiment, the format comprises an array of microholes in a substrate. Besides serving as an ordered array of sample chambers allowing the performance of multiple parallel reactions, the arrays can be used for reagent storage and transfer, library display, reagent synthesis, assembly of multiple identical reactions, dilution and desalting. Use of the arrays facilitates optical analysis of reactions, and allows optical analysis to be conducted in real time. Included within the invention are kits comprising a microhole apparatus and a reaction component of the method(s) to be carried out in the apparatus.

Abstract: Disclosed herein are apparatuses and methods for conducting multiple simultaneous micro-volume chemical and biochemical reactions in an array format. In one embodiment, the format comprises an array of microholes in a substrate. Besides serving as an ordered array of sample chambers allowing the performance of multiple parallel reactions, the arrays can be used for reagent storage and transfer, library display, reagent synthesis, assembly of multiple identical reactions, dilution and desalting. Use of the arrays facilitates optical analysis of reactions, and allows optical analysis to be conducted in real time. Included within the invention are kits comprising a microhole apparatus and a reaction component of the method(s) to be carried out in the apparatus.

Abstract: Disclosed herein are apparatuses and methods for conducting multiple simultaneous micro-volume chemical and biochemical reactions in an array format. In one embodiment, the format comprises an array of microholes in a substrate. Besides serving as an ordered array of sample chambers allowing the performance of multiple parallel reactions, the arrays can be used for reagent storage and transfer, library display, reagent synthesis, assembly of multiple identical reactions, dilution and desalting. Use of the arrays facilitates optical analysis of reactions, and allows optical analysis to be conducted in real time. Included within the invention are kits comprising a microhole apparatus and a reaction component of the method(s) to be carried out in the apparatus.

Abstract: In one embodiment of the present invention, a data-backup method includes partitioning a fingerprint namespace among a cluster of backup servers, the fingerprint namespace comprising fingerprints for representing units of data, each backup server of the cluster of backup servers managing units of data having fingerprints corresponding to an assigned partition of the fingerprint namespace. The method further includes receiving backup information from a client computing device for a block of data comprising units of data, the backup information including at least a fingerprint for each of the units of data and client-specific backup information. In addition, the method includes, utilizing the fingerprint for each of the units of data, deduplicating the units of data in parallel at the cluster of backup servers in accordance with the partitioning step, the deduplicating step comprising identifying ones of the units data already stored by the cluster of backup servers.

Abstract: Disclosed herein are apparatuses and methods for conducting multiple simultaneous micro-volume chemical and biochemical reactions in an array format. In one embodiment, the format comprises an array of microholes in a substrate. Besides serving as an ordered array of sample chambers allowing the performance of multiple parallel reactions, the arrays can be used for reagent storage and transfer, library display, reagent synthesis, assembly of multiple identical reactions, dilution and desalting. Use of the arrays facilitates optical analysis of reactions, and allows optical analysis to be conducted in real time. Included within the invention are kits comprising a microhole apparatus and a reaction component of the method(s) to be carried out in the apparatus.

Abstract: In one embodiment of the present invention, a data-backup method includes partitioning a fingerprint namespace among a cluster of backup servers, the fingerprint namespace comprising fingerprints for representing units of data, each backup server of the cluster of backup servers managing units of data having fingerprints corresponding to an assigned partition of the fingerprint namespace. The method further includes receiving backup information from a client computing device for a block of data comprising units of data, the backup information including at least a fingerprint for each of the units of data and client-specific backup information. In addition, the method includes, utilizing the fingerprint for each of the units of data, deduplicating the units of data in parallel at the cluster of backup servers in accordance with the partitioning step, the deduplicating step comprising identifying ones of the units data already stored by the cluster of backup servers.

Abstract: In one embodiment of the present invention, a data-backup method includes partitioning a fingerprint namespace among a cluster of backup servers, the fingerprint namespace comprising fingerprints for representing units of data, each backup server of the cluster of backup servers managing units of data having fingerprints corresponding to an assigned partition of the fingerprint namespace. The method further includes receiving backup information from a client computing device for a block of data comprising units of data, the backup information including at least a fingerprint for each of the units of data and client-specific backup information. In addition, the method includes, utilizing the fingerprint for each of the units of data, deduplicating the units of data in parallel at the cluster of backup servers in accordance with the partitioning step, the deduplicating step comprising identifying ones of the units data already stored by the cluster of backup servers.

Abstract: A computer-based method includes determining, based at least in part on a quantity of first backup data on a source computer, a data-transfer mode for the first backup data, the data-transfer mode selected from the group consisting of network transfer of the first backup data and physical-media transfer of the first backup data and, responsive to the determining step, transferring the first backup data via the determined data-transfer mode to a server located at a remote destination from the source computer. The physical-media data-transfer mode of the first backup data includes physical transport of physical media to the server. The network-transfer data-transfer mode is accomplished via a network connection and does not include physical transport of physical media.

Abstract: In one embodiment of the present invention, a data-backup method includes partitioning a fingerprint namespace among a cluster of backup servers, the fingerprint namespace comprising fingerprints for representing units of data, each backup server of the cluster of backup servers managing units of data having fingerprints corresponding to an assigned partition of the fingerprint namespace. The method further includes receiving backup information from a client computing device for a block of data comprising units of data, the backup information including at least a fingerprint for each of the units of data and client-specific backup information. In addition, the method includes, utilizing the fingerprint for each of the units of data, deduplicating the units of data in parallel at the cluster of backup servers in accordance with the partitioning step, the deduplicating step comprising identifying ones of the units data already stored by the cluster of backup servers.

Abstract: A computer-based method includes determining, based at least in part on a quantity of first backup data on a source computer, a data-transfer mode for the first backup data, the data-transfer mode selected from the group consisting of network transfer of the first backup data and physical-media transfer of the first backup data and, responsive to the determining step, transferring the first backup data via the determined data-transfer mode to a server located at a remote destination from the source computer. The physical-media data-transfer mode of the first backup data includes physical transport of physical media to the server. The network-transfer data-transfer mode is accomplished via a network connection and does not include physical transport of physical media.

Abstract: A method and apparatus for providing enhanced resolution in photodetector arrays is provided. In a first pass, pixels of a photodetector array are set to low input impedance values, and measurements of each pixel value are taken. In a second pass, selected pixels are set to high input impedance levels and remaining pixels set to low input impedance level, and measurements are taken at The low input impedance pixels. In a third pass, input impedance levels are reversed, and measurements are taken at the low input impedance pixels. A sequence of mathematical calculations are then performed on the measurements taken in the first, second, and third passes to produce half-pixel values for each of the pixels of the array, thereby doubling the resolution of the array without requiring additional circuitry or modification thereto.

Abstract: A method and apparatus for providing flexible photodetector binning are provided. A photodetector having multiple pixels, such as a charged coupled device (CCD), a focal plane array (FPA), an active pixel sensor (APS), or other suitable detector, is provided. A desired bin area is produced in the array by setting at least one of the pixels of the array to a low input impedance level and remaining pixels to a high input impedance level, so that charges generated at the high input impedance pixels diffuse through the detector array to adjacent, low input impedance pixels. The charge is collected at the low input impedance pixels, and corresponds to light detected in the bin area. The impedances of the pixels can be varied to provide bins of desired shapes and/or geometries. The bin areas can extend partially over one or more pixels.