Patents by Inventor Matthew T. Stone

Matthew T. Stone has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210047430
    Abstract: Embodiments described herein relate to novel chromatography media for removing anti-A and/or anti-B antibodies from a sample, as well as methods of using the same. The media described herein have several advantages over previously described media including, acid and alkaline stability.
    Type: Application
    Filed: November 4, 2020
    Publication date: February 18, 2021
    Inventors: Nanying Bian, Chia-Yun Sun, Melissa Holstein, Kristen Cotoni, Matthew T. Stone, Santosh Rahane
  • Publication number: 20210024573
    Abstract: A bind/elute chromatography method and compositions for low salt/low solution conductivity separation of target proteins from a mixture of aggregates and other impurities.
    Type: Application
    Filed: March 26, 2019
    Publication date: January 28, 2021
    Inventors: Matthew T. Stone, Romas Skudas
  • Patent number: 10865224
    Abstract: The present invention relates to improved processes and systems for purification of biological molecules, where the processes can be performed in a continuous manner.
    Type: Grant
    Filed: July 20, 2017
    Date of Patent: December 15, 2020
    Assignee: EMD Millipore Corporation
    Inventors: Alex Xenopoulos, Michael Phillips, Wilson Moya, Jad Jaber, Mikhail Kozlov, Ajish Potty, Matthew T. Stone, William Cataldo, Christopher Gillespie
  • Patent number: 10799371
    Abstract: A stemless humeral component for replacing the humeral head of a patient's humerus includes a support flange having a number of cantilevered legs extending distally away from a bottom surface thereof. Instruments and methods for surgically installing the stemless humeral component are also disclosed.
    Type: Grant
    Filed: September 19, 2018
    Date of Patent: October 13, 2020
    Assignee: DePuy Synthes Products, Inc.
    Inventors: Sarah Anthony, Matthew T. Stone, Scott A. Lubensky, Chad Lawrence, David M. Warlop, Didier Poncet
  • Publication number: 20200253749
    Abstract: A stemless humeral component for replacing the humeral head of a patient's humerus includes a support flange having a number of cantilevered legs extending distally away from a bottom surface thereof. Instruments and methods for surgically installing the stemless humeral component are also disclosed.
    Type: Application
    Filed: April 28, 2020
    Publication date: August 13, 2020
    Inventors: Sarah Anthony, Matthew T. Stone, Scott A. Lubensky, Chad Lawrence, David M. Warlop, Didier Poncet
  • Patent number: 10697982
    Abstract: Embodiments described herein relate to methods of evaluating quality of a chromatography media for removal of anti-A or anti-B antibodies from a sample, where the methods employ use of purified monoclonal IgM-A and IgM-B antibodies.
    Type: Grant
    Filed: August 2, 2016
    Date of Patent: June 30, 2020
    Assignee: Merck Patent GmbH
    Inventors: Matthew T. Stone, Nanying Bian, Santosh Rahane
  • Patent number: 10697983
    Abstract: Embodiments described herein relate to methods of evaluating quality of a chromatography media for removal of anti-A or anti-B antibodies from a sample, where the methods employ use of purified Lectins.
    Type: Grant
    Filed: August 2, 2016
    Date of Patent: June 30, 2020
    Assignee: Merck Patent GmbH
    Inventors: Santosh Rahane, Matthew Turiano, Nanying Bian, Matthew T. Stone
  • Patent number: 10632000
    Abstract: A stemless humeral component for replacing the humeral head of a patient's humerus includes a support flange having a number of cantilevered legs extending distally away from a bottom surface thereof. Instruments and methods for surgically installing the stemless humeral component are also disclosed.
    Type: Grant
    Filed: April 18, 2016
    Date of Patent: April 28, 2020
    Assignee: DePuy Synthes Products, Inc.
    Inventors: Sarah Anthony, Matthew T. Stone, Scott A. Lubensky, Chad Lawrence, David M. Warlop, Didier Poncet
  • Patent number: 10519194
    Abstract: The present invention provides novel and improved protein purification processes which incorporate certain types of carbonaceous materials and result in effective and selective removal, of protein, fragments without adversely affecting the yield of the desired protein product.
    Type: Grant
    Filed: April 4, 2014
    Date of Patent: December 31, 2019
    Assignee: Merck Patent GmbH
    Inventors: Mikhail Kozlov, Matthew T. Stone, Romas Skudas, Kevin Galipeau
  • Publication number: 20190389901
    Abstract: The present invention refers to new species of an ion exchange adsorber which is suitable for the separation of host cell proteins (HCPs), antibody fragments and low molecular weight substances from solutions containing antibodies. The invention especially refers to a process for purifying biological samples by separating biomolecules of interest and impurities, comprising steps of contacting a sample with said chromatography media consisting of fibers, said fibers having imparted thereon functionality enabling ion exchange chromatography and/or hydrophobic interaction.
    Type: Application
    Filed: September 5, 2019
    Publication date: December 26, 2019
    Inventors: Matthew T. Stone, John P. Amara
  • Patent number: 10457720
    Abstract: The present invention refers to a method for the separation of host cell proteins (HCPs), antibody fragments and low molecular weight substances from solutions containing antibodies.
    Type: Grant
    Filed: February 18, 2015
    Date of Patent: October 29, 2019
    Assignee: Merck Patent GmbH
    Inventors: Romas Skudas, Matthias Joehnck, Bianca Edelmann, Simon Braun, Mikhail Kozlov, Matthew T. Stone, Kevin Galipeau
  • Publication number: 20190218250
    Abstract: The present invention provides novel and improved protein purification processes which incorporate certain types of carbonaceous materials and result in effective and selective removal of certain undesirable impurities without adversely affecting the yield of the desired protein product.
    Type: Application
    Filed: March 20, 2019
    Publication date: July 18, 2019
    Inventors: Nanying Bian, Christopher Gillespie, Matthew T. Stone, Mikhail Kozlov, Jie Chen, Martin Siwak
  • Patent number: 10287314
    Abstract: The present invention provides novel and improved protein purification processes which incorporate certain types of carbonaceous materials and result in effective and selective removal of certain undesirable impurities without adversely effecting the yield of the desired protein product.
    Type: Grant
    Filed: June 23, 2015
    Date of Patent: May 14, 2019
    Assignee: EMD Millipore Corporation
    Inventors: Nanying Bian, Christopher Gillespie, Matthew T. Stone, Mikhail Kozlov, Jie Chen, Martin Siwak
  • Publication number: 20190015222
    Abstract: A stemless humeral component for replacing the humeral head of a patient's humerus includes a support flange having a number of cantilevered legs extending distally away from a bottom surface thereof. Instruments and methods for surgically installing the stemless humeral component are also disclosed.
    Type: Application
    Filed: September 19, 2018
    Publication date: January 17, 2019
    Inventors: Sarah Anthony, Matthew T. Stone, Scott A. Lubensky, Chad Lawrence, David M. Warlop, Didier Poncet
  • Patent number: 10159500
    Abstract: An oscillating surgical rasp for use in the surgical preparation of a glenoid of a patient prior to implantation of an augmented glenoid prosthesis comprises an attachment head and a cutting head secured to the attachment head. The attachment head has a body that extends along a longitudinal axis from a first end configured to be secured in a chuck of an oscillating tool to a second end secured to the cutting head. The first end of the body of the attachment head defines an axis of oscillation that extends orthogonal to the longitudinal axis of the oscillating surgical rasp. Surgical methods for the use of such oscillating rasps are also disclosed.
    Type: Grant
    Filed: January 4, 2018
    Date of Patent: December 25, 2018
    Assignee: DEPUY SYNTHES PRODUCTS, INC.
    Inventors: Jason M. Chavarria, Matthew T. Stone
  • Publication number: 20180311053
    Abstract: A stemless humeral component for replacing the humeral head of a patient's humerus includes a support flange having a number of cantilevered legs extending distally away from a bottom surface thereof. Instruments and methods for surgically installing the stemless humeral component are also disclosed.
    Type: Application
    Filed: April 18, 2016
    Publication date: November 1, 2018
    Inventors: Sarah Anthony, Matthew T. Stone, Scott A. Lubensky, Chad Lawrence, David M. Warlop, Didier Poncet
  • Patent number: 10085856
    Abstract: A stemless humeral component for replacing the humeral head of a patient's humerus includes a support flange having a number of cantilevered legs extending distally away from a bottom surface thereof. Instruments and methods for surgically installing the stemless humeral component are also disclosed.
    Type: Grant
    Filed: October 16, 2015
    Date of Patent: October 2, 2018
    Assignee: DePuy Synthes Products, Inc.
    Inventors: Sarah Anthony, Matthew T. Stone, Scott A. Lubensky, Chad Lawrence, David M. Warlop, Didier Poncet
  • Publication number: 20180125508
    Abstract: Oscillating rasps for the surgical preparation of the bone prior to the implantation of a glenoid or acetabular component with complex geometry are disclosed. Surgical methods for the use of such oscillating rasps are also disclosed.
    Type: Application
    Filed: January 4, 2018
    Publication date: May 10, 2018
    Inventors: Jason M. Chavarria, Matthew T. Stone
  • Patent number: 9910041
    Abstract: The present invention provides methods for determining whether activated carbon can be used for removing viruses or a certain virus from a sample containing a target protein.
    Type: Grant
    Filed: April 4, 2014
    Date of Patent: March 6, 2018
    Assignee: EMD Millipore Corporation
    Inventors: Matthew T. Stone, Ushma Mehta, Damon Asher, Patricia Greenhalgh
  • Patent number: 9861376
    Abstract: A method of surgically implanting a glenoid component into the glenoid of a patient is disclosed. The method includes securing a rasp guide into the glenoid of the patient. The method also includes oscillating a surgical rasp over the rasp guide to form a cavity that is shaped to receive the glenoid component. The method also includes implanting the glenoid component in the cavity.
    Type: Grant
    Filed: July 27, 2015
    Date of Patent: January 9, 2018
    Assignee: DEPUY SYNTHES PRODUCTS, INC.
    Inventors: Jason M. Chavarria, Matthew T. Stone