Abstract: Provided herein are compounds according to Formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R5, and R7 are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I) as well as the use of such compounds as M4 receptor agonists.

Abstract: A combustion chamber assembly includes a through hole on the combustion chamber wall bounded on an outer side of the wall by a hole edge and a combustion chamber shingle having a collar bounding a mixing air hole on the outer side of the wall and protruding with a first collar portion beyond the hole edge on the outer side of the wall. A cooling air opening is formed on an inner circumferential surface of a duct portion of the mixing air hole adjoining the first collar portion and extending in the direction of a combustion space, the cooling air opening leading into a cooling air duct which extends through the duct portion and via which cooling air is guided out of the mixing air hole in a direction of a hot side of the shingle facing the combustion space.

Abstract: Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.

Abstract: A collapsible container having a base, an upper frame, and a pair of opposed side walls pivotably connected to side edges of the upper frame. Each of the side walls including an upper panel hingeably connected to a lower panel. The lower panel is hingeably connected to the base. A pair of opposed end walls are pivotably connected to end edges of the upper frame. The end walls are pivotable between an upright position extending from the upper frame to the base between the side walls and a retracted position within the upper frame. A lid is pivotably secured to the upper frame. Other embodiments are also disclosed.

Abstract: A container assembly includes a container body having a side wall extending upward from a base to define a mouth. A lid is pivotably secured to the container body and is pivotable between an open position and a closed position over the mouth of the container body. A collar is secured to an upper edge of the side wall of the container body. The collar reinforces the mouth of the container to prevent deformation thereof, such as by bears, and access between the lid and mouth of the container.

Abstract: A combustion chamber assembly includes a through hole on the combustion chamber wall bounded on an outer side of the wall by a hole edge and a combustion chamber shingle having a collar bounding a mixing air hole on the outer side of the wall and protruding with a first collar portion beyond the hole edge on the outer side of the wall. A cooling air opening is formed on an inner circumferential surface of a duct portion of the mixing air hole adjoining the first collar portion and extending in the direction of a combustion space, the cooling air opening leading into a cooling air duct which extends through the duct portion and via which cooling air is guided out of the mixing air hole in a direction of a hot side of the shingle facing the combustion space.

Abstract: A cart includes a body portion forming a receptacle. A lid is pivotable relative to the body portion. A lock assembly includes a hasp fixed relative to one of the lid or the body portion. A lock is fixed relative to the other of the lid or the body portion and includes a catch for engaging the hasp and an actuator in electrical communication with a controller. The actuator is configured to actuate the catch to selectively secure the hasp relative to the lock.

Abstract: A lid assembly for a cart includes an outer wall defining an outer surface of a lid. An inner wall defines an inner surface of the lid. A hasp is pivotably connected to the lid and is moveable between an extended position and a retracted position. A plurality of flexible arms extend from the lid towards the hasp.

Abstract: A container assembly includes a a container body having a side wall extending upward from a base to define a mouth. A lid is pivotably secured to the container body and is pivotable between an open position and a closed position over the mouth of the container body. A collar is secured to an upper edge of the side wall of the container body. The collar reinforces the mouth of the container to prevent deformation thereof, such as by bears, and access between the lid and mouth of the container.

Abstract: A roll-out cart includes a container body having a side wall extending upward to a mouth of the container body. A lid is pivotably connected to a rear portion of the container body. The lid is pivotable between an open position and a closed position covering the mouth of the container body. A latch selectively secures a front portion of the lid to a front portion of the container body. The latch includes an outer latch assembly having a first actuator. A guard defines a recess on the front portion of the container body. The first actuator of the latch is within the recess.

Abstract: A roll-out cart includes a container body having a side wall extending upward to a mouth of the container body. A lid is pivotably connected to a rear portion of the container body. The lid is pivotable between an open position and a closed position covering the mouth of the container body. A latch selectively secures a front portion of the lid to a front portion of the container body. The latch includes an outer latch assembly having a first actuator. A guard defines a recess on the front portion of the container body. The first actuator of the latch is within the recess.

Abstract: The present disclosure provides powerful technologies for the development, production, characterization, and/or use of stapled peptide compositions. Among other things, the present disclosure provides strategies for defining amino acid sequences particularly amenable or useful for stapling, as well as technologies, reagents, and systems for developing, producing, characterizing, and/or using stapled peptides having such amino acid sequences.

Abstract: A child support system for infants or small children. The child support system includes a child containment device and at least one child support unit detachably mounted to the child containment device. The child containment device includes a frame, liner and, optionally, a raised bassinet mattress. The at least one child support unit may take the form of a bassinet, sleeper, seat, and/or a changing table. The child containment device frame can be collapsible for storage and transport. The child support unit can be configured for use in different modes, in combination with, and/or independent of the child containment device.

Abstract: A collapsible container having a base, an upper frame, and a pair of opposed side walls pivotably connected to side edges of the upper frame. Each of the side walls including an upper panel hingeably connected to a lower panel. The lower panel is hingeably connected to the base. A pair of opposed end walls are pivotably connected to end edges of the upper frame. The end walls are pivotable between an upright position extending from the upper frame to the base between the side walls and a retracted position within the upper frame. A lid is pivotably secured to the upper frame. Other embodiments are also disclosed.

Abstract: Disclosed herein are system, method, and computer program product embodiments for determining a score for a degree of activation of a biological network. An embodiment constructs a tree graph comprising a root node and a set of child nodes. The root node represents a biological network having a reference node and causal connections among a set of nodes that represent biological entities, biological processes, or other biological networks. Each child node represents a particular node in the biological network and is connected to the root node by a signed, directed edge pointing from the root node to that child node. Each child node also has an associated weight based on one or more paths connecting the child node to the reference node in the biological network. The embodiment further scores the tree graph based on scores assigned to the child nodes and the signs of the singed, directed edges.

Abstract: A roll-out cart includes a container body having a side wall extending upward to a mouth of the container body. A lid is pivotably connected to a rear portion of the container body. The lid is pivotable between an open position and a closed position covering the mouth of the container body. A latch selectively secures a front portion of the lid to a front portion of the container body. The latch includes an outer latch assembly having a first actuator. A guard defines a recess on the front portion of the container body. The first actuator of the latch is within the recess.

Abstract: A child support device is provided with a height that is easily adjustable. The child support device includes a seat assembly suspended from at least one upright frame member extending above the seat assembly by at least one support member. The upright frame member includes a cap through which the support member is threaded. The height of the seat assembly is vertically adjustable by repositioning engagement of the support member with the at least one upright frame member.

Abstract: Various embodiments of the present invention are directed to a play yard configured for providing an enclosed space for a child. According to various embodiments, the play yard comprises a rigid support frame and removable, flexible liner. The frame includes one or more moveable retention members configured to engage the liner in order to form a bounded play yard space. By permitting the liner to be secured to the frame via the retention members, a user is able to easily secure the liner to the frame for use and remove the liner from the frame for washing.

Abstract: A composite yarn comprising one or more ultra-high molecular weight polyethylene fibers wrapped around one or more polyurethane-polyurea copolymer fibers.

Abstract: Various embodiments of the present invention are directed to a children's motion device configured to oscillate a child support about a substantially upright axis of rotation. In various embodiments, the portion of the child support configured for supporting the head of a child positioned therein is configured to remain substantially aligned with the axis of rotation as the child support oscillates.