Abstract: A plastic material is provided that comprises a solid polyelectrolyte complex formed between modified alginate comprising ionic groups other than carboxylate groups and a biopolymer comprising oppositely charged ionic groups. Methods of forming, recycling, and decomposing the plastic material are also provided.

Abstract: This disclosure relates to compositions and methods for treating lung disorders, including, for example, pulmonary fibrosis, and other fibrotic disorders. Thioredoxin domain-containing 5 (TXNDC5) is significantly increased in fibrotic lungs from human PF patients. Therefore, a targeted nanoparticle comprising an inhibitor of TXNDC5 was developed, which may have potential to treat pulmonary fibrosis.

Abstract: The present disclosure is generally directed to nanoparticle-containing media exhibiting enhanced optical transparency, related nanoparticles, and associated systems and methods. In certain embodiments, the refractive index (RI) of a nanoparticle comprising thermochromic material (such as VO2) can be made closer to the refractive index of a surrounding medium by tethering a material (such as a gradient copolymer) to the core region of the nanoparticle to modify the refractive index of the nanoparticle. Modifying the refractive index of the nanoparticle to be closer to the refractive index of the medium that contains the nanoparticle can render the nanoparticle-containing medium (also referred, to herein as a composite) more transparent to various wavelengths of electromagnetic radiation while imparting thermochromic properties to the nanoparticle-containing medium.

Abstract: Provided herein are polymer-stabilized CaP nanoparticle formulations and related methods of manufacture. In certain embodiments, the methods reliably and selectively form nanoparticles with homogenous size, charge, and morphology. The CaP nanoparticles include calcium ions and phosphate ions with an ionic polymer, thereby forming stable hybrid nanoparticles. The CaP nanoparticle formulations include powders, suspensions and injectable pastes. According to various embodiments, the polymer-stabilized CaP nanoparticles may be polycation-stabilized (CaP/polymer(+) nanoparticles) or polyanion-stabilized (CaP/polymer(?) nanoparticles). The CaP/polymer nanoparticles can be freeze-dried and stored for months with no loss of properties or changes to their morphology.

Abstract: Provided herein are nanoparticles to encapsulate therapeutic agents and methods of use thereof for intracellular delivery and disease treatment. In particular, the present disclosure provides polymersomes for use in the delivery of therapeutic agents, e.g. stapled peptides, to diseased (e.g. cancer) cells.

Abstract: The disclosure provides products and methods of treating diseases and disorders involving microbial pathogens, such as intestinal microbial pathogens, e.g., Pseudomonas aeruginosa, by administering an effective amount of a phosphorylated polyethylene glycol compound of defined structural organization. Those diseases and disorders characterized by an epithelium attacked by a microbial pathogen are contemplated, including gastrointestinal infections and inflammation, e.g., treatment of intestinal or esophageal anastomosis or treatment or suppression of anastomotic leakage.

Abstract: The disclosure provides products and methods of treating diseases and disorders involving microbial pathogens, such as intestinal microbial pathogens, e.g., Pseudomonas aeruginosa, by administering an effective amount of a phosphorylated polyethylene glycol compound of defined structural organization. Those diseases and disorders characterized by an epithelium attacked by a microbial pathogen are contemplated, including gastrointestinal infections and inflammation, e.g., treatment of intestinal or esophageal anastomosis or treatment or suppression of anastomotic leakage.

Abstract: Redox gating, intrinsically apart from conventional electrolyte gating, combines reversible redox functionalities with common ionic electrolyte moieties to engineer charge transport for power efficient phase control. A colossal sheet carrier density modulation beyond 1016/cm2 as well as up to thousand durable cycling can be reached at the subvolt regime in archetypical functional oxide thin films without unbridled perturbations from ionic defects, which include either cation/anion vacancy or ionic intercalated species like proton. Besides, the redox gating represents a simply and practical way to decouple the electrical and structural phase transitions, improving the device longevity and operation response time. The redox gating works for a wide variety of materials regardless of its crystallinity or crystallographic orientation, including all other functional heterostructures and low-dimensional quantum materials composed of sustainable elements.

Abstract: The disclosure provides products and methods of treating diseases and disorders involving microbial pathogens, such as intestinal microbial pathogens, e.g., Pseudomonas aeruginosa, by administering an effective amount of a phosphorylated polyethylene glycol compound of defined structural organization. Those diseases and disorders characterized by an epithelium attacked by a microbial pathogen are contemplated, including gastrointestinal infections and inflammation, e.g., treatment of intestinal or esophageal anastomosis or treatment or suppression of anastomotic leakage.

Abstract: Provided herein are polymer-stabilized CaP nanoparticle formulations and related methods of manufacture. In certain embodiments, the methods reliably and selectively form nanoparticles with homogenous size, charge, and morphology. The CaP nanoparticles include calcium ions and phosphate ions with an ionic polymer, thereby forming stable hybrid nanoparticles. The CaP nanoparticle formulations include powders, suspensions and injectable pastes. According to various embodiments, the polymer-stabilized CaP nanoparticles may be polycation-stabilized (CaP/polymer(+) nanoparticles) or polyanion-stabilized (CaP/polymer(-) nanoparticles). The CaP/polymer nanoparticles can be freeze-dried and stored for months with no loss of properties or changes to their morphology.

Abstract: Provided herein are enzymatically-cleavable peptide amphiphiles and methods of use thereof.

Abstract: Disclosed are compositions and methods related to clot-binding head groups. The disclosed targeting is useful for treatment of cancer and other diseases and disorders.