Abstract: Systems and methods for providing digital platform supply chain solutions for an integrated supply chain automation platform by transforming official, standard physical documentation into official, standard digital documentation. The systems and methods may include an integrated supply chain automation platform. The systems and methods may include an artificial intelligence/machine learning (“AI/ML”) processor. The AI/ML processor may be operable to parse uploaded documents, output matched documents, and identify discrepancies within the platform. The systems and methods may include a network of applications. The network of applications may be contained in a hybrid cloud environment. The systems and methods may include a middleware engine. The middleware engine may be operable to connect, within the hybrid cloud environment: the platform, the AI/ML processor, and the network of applications.

Abstract: The present disclosure provides compounds, pharmaceutically acceptable compositions thereof and methods of using the same.

Abstract: Systems, methods, and computer-readable media for processing transactions utilizing a gaming system, where the transactions are initiated by game providers. The system may include a remote gaming server, a remote gaming server bridge, a gaming system, an eligibility verifier, a wallet, an event generator, an event publisher, a session manager, an alert system, and a pendings fixer. The remote gaming server may transmit a request (e.g., a transaction) to the gaming system, where the remote gaming server bridge may translate the request such that it is processable and understandable by the gaming system. The wallet may update an account associated with the user, including by depositing a sum or withdrawing the sum from the account. The event generator may generate a system event associated with the transaction, and the event publisher may publish the system event to a data store.

Abstract: A device for displaying physiological parameter measurements is disclosed. The device displays a graphical user interface including playback of a plurality of waveforms. Each waveform of the plurality of waveforms representing a physiological parameter measured over a period of time. The plurality of waveforms including at least: a first waveform representing a first physiological parameter; and a second waveform representing a second physiological parameter. The device receives a settings adjustment on the graphical user interface. The device adjusts the playback of the second waveform relative to the first waveform based on the settings adjustment. The playback of the second waveform is adjusted to change a sweep speed of the second waveform such that a length of the second waveform differs from a length of the first waveform over the period of time.

Abstract: Systems, methods, and computer-readable media for processing transactions utilizing a gaming system, where the transactions are initiated by game providers. The system may include a remote gaming server, a remote gaming server bridge, a gaming system, an eligibility verifier, a wallet, an event generator, an event publisher, a session manager, an alert system, and a pendings fixer. The remote gaming server may transmit a request (e.g., a transaction) to the gaming system, where the remote gaming server bridge may translate the request such that it is processable and understandable by the gaming system. The wallet may update an account associated with the user, including by depositing a sum or withdrawing the sum from the account. The event generator may generate a system event associated with the transaction, and the event publisher may publish the system event to a data store.

Abstract: The present disclosure provides methods and formulations for treating a patient suffering from one or more of chronic inflammatory injury, metaplasia, dysplasia or cancer of esophageal tissue and gastric tissue, which method comprises administering to the patient an agent that selectively kills or inhibits the proliferation or differentiation of pathogenic Barrett's Esophagus stem cells (BESCs) or Gastric Intestinal Metaplasia stem cells (GIMSCs) relative to normal regenerative esophageal stem cells or gastric stem cells in the tissue in which the BESCs or GIMSCs are found.

Abstract: Described herein is a smart device component comprising a polyamide composition comprising at least 50% by weight (wt %) of a polyamide comprising at least 50% by mol (mol %) of recurring units of —NH—(CH2)8-C(O)— and/or —NH—(CH2)9-C(O)—; from 0 wt % to 50 wt % of at least one reinforcing agent, and from 0 wt % to 30 wt % of at least one additive, with low water uptake, high melting temperature and good dimensional stability, wherein no recurring unit of the polyamide is fully aromatic. The present invention also relates to use of the polyamide composition in manufacturing a smart device component.

Abstract: The present invention addresses IBD from the standpoint of mucosal stem cells cloned from defined regions of the gastrointestinal tract. In the case of pediatric Crohn's disease, for example, isolation of those stem cells according to the methods of the present invention reveals a pattern of inflammatory gene expression in stem cells from the terminal ileum and colon that is epigenetically maintained despite months of continuous cultivation in the absence of immune or stromal cells, or of intestinal microbes. Superimposed on this distributed inflammatory phenotype is a differentiation defect that profoundly and specifically alters the mucosal barrier properties of the terminal ileum. The co-existence of diseased and normal stem cells within the same endoscopic biopsies of Crohn's disease patients implicates an epigenetically enforced heterogeneity among mucosal stem cells in the dynamics of this condition.

Abstract: Systems and methods are disclosed for automated rule-based income validation using electronic transaction data. One or more processors receive transaction data associated with a financial account, including data elements representing income transactions. Characteristics of the data elements are analyzed, and an income type label and an income source label are associated with the data elements. A cluster of data elements is identified as associated with a first income source label, the identified cluster including data elements associated with a first income type label. The cluster of data elements is verified, and data associated with the verified cluster is analyzed to determine one or more income streams. Based on a transaction rule associated with the one or more income streams, a composite income is calculated, and a net income associated with the first income type is determined. Based on the determined net income, a gross income distribution is generated.

Abstract: Described herein are polymer compositions including a polyphthalamide having a carbon/amide molar ratio greater than 8, a functionalized polyolefin, and a glass fiber, where the weight ratio of the functionalized polyolefin to the total weight of the polyphthalamide and the functionalized polyolefin in the polymer composition is more than 0 and at most 27%. It was surprisingly discovered that the polymer compositions had excellent dielectric performance, acid resistance, and improved mechanical performance, particularly tensile elongation and un-notched Izod impact, relative to corresponding polymer compositions omitting such functionalized polyolefin. Due to the excellent performance, the polymer composition can be desirably incorporated into mobile electronic device components.

Abstract: A polyamide composition is provided and comprises at least one polyamide characterized by high glass transition temperature (Tg), at least one fibrous filler and at least one additive, wherein the composition can be used to manufacture articles, and in electrostatic painting applications.

Abstract: The present disclosure provides methods and formulations for treating a patient suffering from one or more of chronic inflammatory injury, metaplasia, dysplasia or cancer of esophageal tissue and gastric tissue, which method comprises administering to the patient an agent that selectively kills or inhibits the proliferation or differentiation of pathogenic Barrett's Esophagus stem cells (BESCs) or Gastric Intestinal Metaplasia stem cells (GIMSCs) relative to normal regenerative esophageal stem cells or gastric stem cells in the tissue in which the BESCs or GIMSCs are found.

Abstract: The present disclosure addresses IBD from the standpoint of inhibiting or ablating pathogenic mucosal stem cells cloned from defined regions of disease in the gastrointestinal tract. In the case of Crohn's disease, for example, isolation of those stem cells according to the methods of the present disclosure reveals a pattern of inflammatory gene expression in stem cells from the terminal ileum and colon that is epigenetically maintained despite months of continuous cultivation in the absence of immune or stromal cells, or of intestinal microbes. Superimposed on this distributed inflammatory phenotype is a differentiation defect that profoundly and specifically alters the mucosal barrier properties of the terminal ileum. The co-existence of diseased and normal stem cells within the same endoscopic biopsies of Crohn's disease patients implicates an epigenetically enforced heterogeneity among mucosal stem cells in the dynamics of this condition.

Abstract: The present disclosure provides methods and formulations for treating a patient suffering from one or more of chronic inflammatory injury, metaplasia, dysplasia or cancer of an epithelial tissue, which method comprises administering to the patient an agent that selectively kills or inhibits the proliferation or differentiation of pathogenic epithelial stem cells (PESCs) relative to normal epithelial stem cells in the tissue in which the PESCs are found. Representative epithelial tissues include pulmonary, genitourinary, gastrointestinal/esophageal, pancreatic and hepatic tissues.

Abstract: The present disclosure addresses inflammatory lung diseases, such as COPD, and fibrotic lung diseases such as idiopathic pulmonary fibrosis, from the standpoint of inhibiting or ablating pathogenic epithelial stem cells found in the pulmonary tract.

Abstract: Disclosed are binder-drug conjugates that are activated extracellular, with both the binder and the free drug moiety have pharmacological activity.

Abstract: The present invention addresses IBD from the standpoint of mucosal stem cells cloned from defined regions of the gastrointestinal tract. In the case of pediatric Crohn's disease, for example, isolation of those stem cells according to the methods of the present invention reveals a pattern of inflammatory gene expression in stem cells from the terminal ileum and colon that is epigenetically maintained despite months of continuous cultivation in the absence of immune or stromal cells, or of intestinal microbes. Superimposed on this distributed inflammatory phenotype is a differentiation defect that profoundly and specifically alters the mucosal barrier properties of the terminal ileum. The co-existence of diseased and normal stem cells within the same endoscopic biopsies of Crohn's disease patients implicates an epigenetically enforced heterogeneity among mucosal stem cells in the dynamics of this condition.

Abstract: Described herein are stein cells and related factors for treating degenerative and inflammatory disorders of lung tissue.

Abstract: In a process for producing styrene, benzene is alkylated with ethylene to produce ethylbenzene and at least some of the ethylbenzene is dehydrogenated to produce styrene, together with benzene and toluene as by-products. At least part of the benzene by-product is passed through a bed of an adsorbent comprising at least one of an acidic clay, alumina, an acidic ion exchange resin and an acidic molecular sieve to remove basic nitrogenous impurities therefrom and produce a purified benzene by-product, which is then recycled to the alkylation step.

Abstract: A system for sealing a beverage container includes a crown defining a bottom surface. A liner that includes an oxygen scavenger is coupled to the crown such that a top surface of the liner contacts the bottom surface of the crown. The bottom surface of the liner supports printed indicia where the bottom surface of the liner and the printed indicia are exposed to a beverage contained in the beverage container.