Abstract: Provided herein are compositions, methods, and systems for DNA modification. In particular, provided herein are compositions, and systems comprising TnpB-like nuclease-dead repressors (dTnpB/TldRs), dCas12f or dCas12f-like proteins, and/or a TnpB-transposase fusion proteins and methods using thereof.

Abstract: Disclosed herein are methods of administering compositions comprising a mixture of salts that induce purgation of the colon and are useful to cleanse the colon. Furthermore, the disclosed methods prevent degradation of PEG and allow for cleansing of the colon without the use of adjunct laxatives, including stimulant laxatives such as bisacodyl. The disclosed methods are superior to the prior art in that they allow for higher tolerability, improved safety, lower volumes, and improved patient compliance.

Abstract: Techniques to allow for increases in the accuracy of the determination of properties of a formation (e.g., a formation's fluid content, porosity, density, etc.) or seismic velocity, shear wave information, etc. are disclosed herein. The techniques include generating initial input data comprising based at least in part on initial seismic data, modeling the initial input data to generate synthetic seismic data based on different combinations of the initial input data, iteratively updating a value of each particle of a set of particles utilizing the synthetic seismic data to generate a final set of particles and outputting the final set of particles as a target distribution.

Abstract: The application discloses methods and compositions for inhibiting functions associated with Interleukin-8 (IL8). The methods and compositions may involve the use of aptamers for binding to IL8 and preventing or reducing association of IL8 with CXCR1, CXCR2, or both. The methods and compositions may include one or more aptamers that bind to an N-terminal domain of IL8. The methods and compositions may include one or more aptamers that bind to a hydrophobic pocket of IL8. The methods and compositions may include one or more aptamers that bind to an N-loop of IL8. The methods and compositions may include one or more aptamers that bind to a GAG binding site of IL8. The application further provides anti-IL8 aptamers for the treatment of ocular diseases or disorders. In some cases, the anti-IL8 aptamers may have a stem-loop secondary structure.

Abstract: Disclosed herein are methods of administering compositions comprising a mixture of salts that induce purgation of the colon and are useful to cleanse the colon. Furthermore, the disclosed methods prevent degradation of PEG and allow for cleansing of the colon without the use of adjunct laxatives, including stimulant laxatives such as bisacodyl. The disclosed methods are superior to the prior art in that they allow for higher tolerability, improved safety, lower volumes, and improved patient compliance.

Abstract: In some implementations, a user device may transmit a plurality of credentials, to a streaming host, associated with a user and corresponding to a plurality of streaming services. The user device may receive, from the streaming host, instructions for a user interface (UI) indicating a suggested program based on watch histories associated with the user and including an element associated with the suggested program. The user device may output the UI and may detect an interaction with the element. The user device may transmit, to the streaming host, an indication of the interaction. The user device may receive, from the streaming host and in response to the indication of the interaction, a stream of the suggested program. The user device refrains from executing an application associated with a selected streaming service, in the plurality of streaming services, that hosts the suggested program.

Abstract: Provided is a disinfecting cap for a fluid path element having an inner lumen and an outer cylindrical wall surrounding the inner lumen. The disinfecting cap includes a housing configured to receive the inner lumen and the outer cylindrical wall of the fluid path element. The housing has an open proximal end, a closed distal end, and a sidewall extending between the open proximal end and the closed distal end to define an interior volume. A sleeve protrudes proximally from an inner surface of the closed distal end and defines an opening configured to receive the inner lumen of the fluid path element. A compressible absorbent material at least partially saturated with a disinfecting fluid is disposed within the interior volume of the housing and surrounding at least a portion of the sleeve.

Abstract: Disclosed herein are methods of administering compositions comprising a mixture of salts that induce purgation of the colon and are useful to cleanse the colon. Furthermore, the disclosed methods prevent degradation of PEG and allow for cleansing of the colon without the use of adjunct laxatives, including stimulant laxatives such as bisacodyl. The disclosed methods are superior to the prior art in that they allow for higher tolerability, improved safety, lower volumes, and improved patient compliance.

Abstract: A bed includes components to control temperature of a sleep surface, for example based on time and historical usage patterns by a user. In some embodiments the temperature of the sleep surface is controlled based on information indicating a sleep state of the user. In some embodiments the temperature is dynamically adjusted so to achieve particular sleep states and/or sleep patterns for the user. In some embodiments the temperature and timing of temperature adjustments is iteratively adjusted over multiple sleep sessions so to achieve improvements in sleep states and/or sleep quality for the user.

Abstract: Disclosed herein are methods of administering compositions comprising a mixture of salts that induce purgation of the colon and are useful to cleanse the colon. Furthermore, the disclosed methods prevent degradation of PEG and allow for cleansing of the colon without the use of adjunct laxatives, including stimulant laxatives such as bisacodyl. The disclosed methods are superior to the prior art in that they allow for higher tolerability, improved safety, lower volumes, and improved patient compliance.

Abstract: In some implementations, a multimedia host may stream multimedia content to a user device, where a current timestamp associated with the multimedia content is tracked. The multimedia host may receive, from the user device, an indication of an interaction, where the interaction is associated with the current timestamp and a portion of a pixel space of the multimedia content. The multimedia host may receive, from the user device, text provided by a user of the user device and may provide the text to a machine learning model to receive an indication of a proposed change to the multimedia content. The multimedia host may transmit, to a ticket system, a command to open a ticket including the text and the proposed change.

Abstract: In some implementations, a user device may transmit a plurality of credentials, to a streaming host, associated with a user and corresponding to a plurality of streaming services. The user device may receive, from the streaming host, instructions for a user interface (UI) indicating a suggested program based on watch histories associated with the user and including an element associated with the suggested program. The user device may output the UI and may detect an interaction with the element. The user device may transmit, to the streaming host, an indication of the interaction. The user device may receive, from the streaming host and in response to the indication of the interaction, a stream of the suggested program. The user device refrains from executing an application associated with a selected streaming service, in the plurality of streaming services, that hosts the suggested program.

Abstract: Disclosed herein are methods of administering compositions comprising a mixture of salts that induce purgation of the colon and are useful to cleanse the colon. Furthermore, the disclosed methods prevent degradation of PEG and allow for cleansing of the colon without the use of adjunct laxatives, including stimulant laxatives such as bisacodyl. The disclosed methods are superior to the prior art in that they allow for higher tolerability, improved safety, lower volumes, and improved patient compliance.

Abstract: This disclosure to the methods for nucleic acid modification, gene targeting, and gene tagging comprising an engineered Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-associated transposon (CAST) system with a donor DNA comprising at least one engineered transposon end sequence and/or at least one integration co-factor protein. More particularly, the present disclosure provides systems comprising: an engineered CAST system or one or more nucleic acids encoding the engineered CAST system, wherein the CAST system comprises at least one or all of: i) at least one Cas protein, ii) one or more transposon-associated proteins, iii) at least one guide RNA (gRNA) complementary to at least a portion of a target nucleic acid sequence; and a donor nucleic acid comprising a cargo nucleic acid sequence flanked by at least one engineered transposon end sequence and/or at least one integration co-factor protein, or a nucleic acid encoding thereof.

Abstract: Disclosed herein are methods of administering compositions comprising a mixture of salts that induce purgation of the colon and are useful to cleanse the colon. Furthermore, the disclosed methods prevent degradation of PEG and allow for cleansing of the colon without the use of adjunct laxatives, including stimulant laxatives such as bisacodyl. The disclosed methods are superior to the prior art in that they allow for higher tolerability, improved safety, lower volumes, and improved patient compliance.

Abstract: An intracameral injector needle having a substantially cylindrical body defining a longitudinal flow path therein, and having a proximal end, a distal end, an outer peripheral face and a bevel region. A first bevel of the bevel region has a first bevel angle with respect to the outer peripheral face. A second bevel of the bevel region extends from the first bevel to the proximal end. The second bevel includes a tip of the intracameral injector needle, and has a second bevel angle with respect to the outer peripheral face, where the second bevel angle is different from the first bevel angle, the first bevel and the second bevel defining a transition therebetween. The transition is at least one of: (1) longitudinally positioned between the tip of the intracameral injector needle and a location of a maximum width of the bevel region; and (2) vertically disposed at a position below 50% of a maximum height of the bevel region.

Abstract: Disclosed herein are methods of administering compositions comprising a mixture of salts that induce purgation of the colon and are useful to cleanse the colon. Furthermore, the disclosed methods prevent degradation of PEG and allow for cleansing of the colon without the use of adjunct laxatives, including stimulant laxatives such as bisacodyl. The disclosed methods are superior to the prior art in that they allow for higher tolerability, improved safety, lower volumes, and improved patient compliance.

Abstract: A compound having the formula (I) R1-COOH. R1 is an alkyl or alkenyl group having a C7-11 backbone, optionally branched with a C1-6 alkyl group at any C position in the backbone, or a pharmaceutically acceptable salt, amide or ester thereof. The backbone of the alkyl or alkenyl group, and/or the branched alkyl groups, are optionally interrupted by one or more heteroatoms, provided that when R1 is an alkyl group having a C7 backbone, the branching does not consist only of a hexyl group at the a carbon of R1, or only of a methyl group at the ? carbon of R1, or of only single methyl groups at both the ?and ?-1 carbons of R1, and provided that when R1 is an alkyl group having a C8 or C11 backbone, the branching does not consist only of a propyl group at the a carbon of R1.

Abstract: Embodiments described herein relate generally to medical implant delivery apparatuses and methods. In some embodiments, an intracameral injector needle has a substantially cylindrical body defining a longitudinal flow path therein. The body has a proximal end, a distal end, an outer peripheral face and a bevel region, with the longitudinal flow path extending from the proximal end to the distal end. A first bevel of the bevel region has a first bevel angle with respect to the outer peripheral face. A second bevel of the bevel region extends from the first bevel to the proximal end. The second bevel includes a tip of the intracameral injector needle, and has a second bevel angle with respect to the outer peripheral face, where the second bevel angle is different from the first bevel angle, the first bevel and the second bevel defining a transition therebetween. The bevel region has a tapered width.

Abstract: Disclosed herein are methods of administering compositions comprising a mixture of salts that induce purgation of the colon and are useful to cleanse the colon. Furthermore, the disclosed methods prevent degradation of PEG and allow for cleansing of the colon without the use of adjunct laxatives, including stimulant laxatives such as bisacodyl. The disclosed methods are superior to the prior art in that they allow for higher tolerability, improved safety, lower volumes, and improved patient compliance.