Patents by Inventor Matthew Wall
Matthew Wall has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10919089Abstract: The present disclosure, among other things, provides new technologies for preparation of anisotropic nanoparticle cores (e.g., anisotropic gold nanoparticle cores) and compositions thereof. Provided technologies show a number of advantages as compared with previously available options for preparing anisotropic nanoparticle cores, including, for example, that they typically utilize mild reaction conditions and, in many embodiments, only environmentally benign agents. The present invention therefore provides “green” nanoparticle technologies. Surprisingly, in many cases, the same set of reactants can be used, under modestly different conditions, to generate nanoparticle cores of different shapes. The present invention provides selection rules for reaction conditions that generate populations containing particular shapes of interest.Type: GrantFiled: June 30, 2016Date of Patent: February 16, 2021Assignee: Memorial Sloan Kettering Cancer CenterInventors: Moritz Kircher, Matthew Wall, Stefan Harmsen
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Publication number: 20200309135Abstract: A horizontal pumping system has a motor, a pump driven by the motor and a priming module. The pump has a discharge on a first end of the pump, a suction end on a second end of the pump, and a plurality of stages between the suction end and the discharge. Each of the plurality of stages includes an impeller and a diffuser that encases the impeller. Each diffuser is an independent pressure vessel. The priming module may be a wet priming module or a dry priming module. The priming module permits the use of the horizontal pumping system in many applications in which the liquid is not naturally present at the pump intake.Type: ApplicationFiled: March 26, 2020Publication date: October 1, 2020Applicant: Baker Hughes, a GE Company, LLCInventors: Jordan Kirk, Matthew Walls, Deric Thomas, Leslie Reid
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Patent number: 10688202Abstract: The present disclosure, among other things, provides new technologies for preparation of medical isotope labeled metal(loid) chalcogen nanoparticles for use in medical imaging and/or therapeutic applications. Provided technologies show a number of advantages as compared with previously available options for preparing and utilizing medical isotopes, including, for example, they utilize metal(loid) chalcogen nanoparticles that serve as universal binders (e.g., via covalent or non-covalent (e.g., chelate) bonds) for medical isotopes to provide medical isotope labeled metal(loid) chalcogen nanoparticles. Surprisingly, the same metal(loid) chalcogen nanoparticles may be used to bind (e.g., covalent or non-covalent e.g., chelation) bonding) a wide variety of different useful medical isotopes without the use of traditional chelating agents.Type: GrantFiled: July 28, 2015Date of Patent: June 23, 2020Assignee: Memorial Sloan-Kettering Cancer CenterInventors: Matthew A. Wall, Travis Shaffer, Stefan Harmsen, Jan Grimm, Moritz F. Kircher
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Publication number: 20200158125Abstract: A surface pumping system has a motor and a pump driven by the motor. The pump has a discharge on a first end of the pump, a suction end on a second end of the pump, and a plurality of stages between the suction end and the discharge. Each of the plurality of stages includes an impeller and a diffuser that encases the impeller. Each diffuser is an independent pressure vessel. In some embodiments, the diffuser and impeller in each stage are large and configured for use in low net positive suction head (NPSH) applications.Type: ApplicationFiled: November 15, 2019Publication date: May 21, 2020Applicant: Baker Hughes, a GE Company, LLCInventors: Deric Thomas, Gustav Guijt, Matthew Walls, Jordan Kirk
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Patent number: 10322194Abstract: The present disclosure, among other things, provides a composition including a nanoscale core; a plurality of capping agent entities associated on the core; an outer encapsulant layer; and a plurality of dopant entities distributed at locations selected from the group consisting of: on or within the nanoscale core, on or between capping agent entities, on or within the encapsulating layer, and combinations thereof. Provided technologies can achieve unprecedented levels of dopant entity density and/or surface localization, which, for a SE(R)RS-active agent dopant, results in dramatically improved signal intensity and/or imaging sensitivity.Type: GrantFiled: August 30, 2013Date of Patent: June 18, 2019Assignee: Sloan-Kettering Institute for Cancer ResearchInventors: Moritz Kircher, Stefan Harmsen, Matthew Wall
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Patent number: 10105456Abstract: The present disclosure, among other things, provides a composition of a particle including a substrate; at least a first condensation layer comprising at least a first dopant entity; and at least a second layer comprising a second dopant entity. In some embodiments, different dopant entities are included in different layers. In some embodiments, such dopant entities are or comprise detectable entities. This, in some embodiments, provided technologies achieve multi-modality particles. Among the many advantages of provided technologies include the ability to image particles by a plurality of distinct imaging modalities and/or in a plurality of contexts (e.g., pre-surgical, intraoperative and/or post-surgical environments).Type: GrantFiled: December 19, 2013Date of Patent: October 23, 2018Assignee: Sloan-Kettering Institute for Cancer ResearchInventors: Stefan Harmsen, Matthew Wall, Moritz Kircher
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Publication number: 20180193910Abstract: The present disclosure, among other things, provides new technologies for preparation of anisotropic nanoparticle cores (e.g., anisotropic gold nanoparticle cores) and compositions thereof. Provided technologies show a number of advantages as compared with previously available options for preparing anisotropic nanoparticle cores, including, for example, that they typically utilize mild reaction conditions and, in many embodiments, only environmentally benign agents. The present invention therefore provides “green” nanoparticle technologies. Surprisingly, in many cases, the same set of reactants can be used, under modestly different conditions, to generate nanoparticle cores of different shapes. The present invention provides selection rules for reaction conditions that generate populations containing particular shapes of interest.Type: ApplicationFiled: June 30, 2016Publication date: July 12, 2018Inventors: Moritz Kircher, Matthew Wall, Stefan Harmsen
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Publication number: 20170266328Abstract: The present disclosure, among other things, provides new technologies for preparation of medical isotope labeled metal(loid) chalcogen nanoparticles for use in medical imaging and/or therapeutic applications. Provided technologies show a number of advantages as compared with previously available options for preparing and utilizing medical isotopes, including, for example, they utilize metal(loid) chalcogen nanoparticles that serve as universal binders (e.g., via covalent or non-covalent (e.g., chelate) bonds) for medical isotopes to provide medical isotope labeled metal(loid) chalcogen nanoparticles. Surprisingly, the same metal(loid) chalcogen nanoparticles may be used to bind (e.g., covalent or non-covalent e.g., chelation) bonding) a wide variety of different useful medical isotopes without the use of traditional chelating agents.Type: ApplicationFiled: July 28, 2015Publication date: September 21, 2017Applicant: Memorial Sloan Kettering Cance CenterInventors: Matthew A. Wall, Travis Shaffer, Stefan Harmsen, Jan Grimm, Moritz F. Kircher
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Publication number: 20150328346Abstract: The present disclosure, among other things, provides a composition of a particle including a substrate; at least a first condensation layer comprising at least a first dopant entity; and at least a second layer comprising a second dopant entity. In some embodiments, different dopant entities are included in different layers. In some embodiments, such dopant entities are or comprise detectable entities. This, in some embodiments, provided technologies achieve multi-modality particles. Among the many advantages of provided technologies include the ability to image particles by a plurality of distinct imaging modalities and/or in a plurality of contexts (e.g., pre-surgical, intraoperative and/or post-surgical environments).Type: ApplicationFiled: December 19, 2013Publication date: November 19, 2015Inventors: Stefan HARMSEN, Matthew WALL, Moritz KIRCHER
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Publication number: 20150258218Abstract: The present disclosure, among other things, provides a composition including a nanoscale core; a plurality of capping agent entities associated on the core; an outer encapsulant layer; and a plurality of dopant entities distributed at locations selected from the group consisting of: on or within the nanoscale core, on or between capping agent entities, on or within the encapsulating layer, and combinations thereof. Provided technologies can achieve unprecedented levels of dopant entity density and/or surface localization, which, for a SE(R)RS-active agent dopant, results in dramatically improved signal intensity and/or imaging sensitivity.Type: ApplicationFiled: August 30, 2013Publication date: September 17, 2015Inventors: Moritz Kircher, Stefan Harmsen, Matthew Wall
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Patent number: RE43146Abstract: A search engine is provided for searching, evaluating and/or optimizing an emergent model on a computer network. The emergent model is created by independently generating, publishing references to, and subscribing to data objects and/or function objects in a manner free of a globally predefined data object and/or function object definition. Messages are sent to referencing data objects and/or function objects when referenced data objects and/or function objects change. Functions within the function objects are solved when the messages are received. The data objects and/or the function objects are stored in a distributed manner across multiple computing devices on a computer network. At least one of the data objects is defined as an input data object and at least one of the data objects is defined as an output data object to a search engine, the search engine generating changes to the input data object until the output data object satisfies a predefined criteria.Type: GrantFiled: May 1, 2008Date of Patent: January 24, 2012Assignee: Ocls Applications, LLCInventors: Matthew Wall, Timothy Wall