Abstract: The present disclosure relates to methods of treating or preventing cancer (e.g., advanced solid cancer) using Compound No. 1 or Compound No. 2: or a pharmaceutically acceptable salt thereof. The present disclosure also relates to pharmaceutical compositions and pharmaceutical kits suitable for the treatment or prevention.

Abstract: A gauge hanger 10 and a setting tool 12 are disclosed. The setting tool 12 includes an electro-mechanical impact driver 26 and a drive shaft 28 which extends out of an outer casing 12. The gauge hanger 10 comprises a nut 32 which can be engaged by the drive shaft 28. When the nut 32 is rotated it can draw a threaded mandrel 36 upwardly in a wellbore. This causes the grippers 40 in a linkage assembly to be driven radially outwardly so that they can grip the sides of the wellbore. A pin 52 is designed to shear once the grippers have engaged with the sides of the wellbore so that the setting tool 12 can be lifted clear.

Abstract: A method of transmitting data acoustically through a tubular structure, such as a drill string or production tubing in an oil or gas well, predominantly comprising a series of tubing sections (1)joined end to end by couplings (2), at least a preponderance of the tubing sections having an axial length of at least a dimension X between couplings and at least a preponderance of the couplings having an axial length of no more than a dimension x, where X is substantially greater than x. The method comprises propagating acoustic signals along the structure, between transducers (9,10) over a distance N of at least 10X, in the form of tone bursts at least predominantly comprising a selected guided wave mode (preferably the L(0, 1) mode at low frequency) with a wavelength of at least 2x, and each burst having a temporal length of substantially less than 2N/C and preferably no more than 2X/C, where C is the phase velocity of the selected mode.