Abstract: Methods and systems of using X-ray radiation to irradiate X-ray sensitive biomolecules to allow for specific control over the behavior of cells via the X-ray irradiation are provided. The systems and methods are influenced by the field of optogenetics, which uses visible light instead of X-ray radiation. X-ray stimulation penetrates both bone and soft tissue with very little attenuation and can be performed without any physical contact with the sample. Image reconstruction methods using deep learning are also provided. A deep learning algorithm can be used to obtain a reconstructed image from raw data obtained via medical imaging, either with or without first performing a conventional algorithm.

Abstract: Imaging systems and methods are provided. Systems and methods of the subject invention can include the use of nanoparticles (for example, nanophosphors) within a sample to be imaged. Excitation with radiation, such X-ray radiation, can be performed on the nanoparticles to give rise to a change in one or more resonance parameters of the nanoparticles, and this change can be measured using magnetic resonance imaging to provide localization information.