Patents by Inventor Matthew Weitzman

Matthew Weitzman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6203975
    Abstract: A recombinant adenovirus and a method for producing the virus are provided which utilize a recombinant shuttle vector comprising adenovirus DNA sequence for the 5′ and 3′ cis-elements necessary for replication and virion encapsidation in the absence of sequence encoding viral genes and a selected minigene linked thereto, and a helper adenovirus comprising sufficient adenovirus gene sequences necessary for a productive viral infection. Desirably the helper gene is crippled by modifications to its 5′ packaging sequences, which facilitates purification of the viral particle from the helper virus.
    Type: Grant
    Filed: October 21, 1999
    Date of Patent: March 20, 2001
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: James M. Wilson, Krishna J. Fisher, Shu-Jen Chen, Matthew Weitzman
  • Patent number: 6001557
    Abstract: A recombinant adenovirus and a method for producing the virus are provided which utilize a recombinant shuttle vector comprising adenovirus DNA sequence for the 5' and 3' cis-elements necessary for replication and virion encapsidation in the absence of sequence encoding viral genes and a selected minigene linked thereto, and a helper adenovirus comprising sufficient adenovirus gene sequences necessary for a productive viral infection. Desirably, the helper gene is crippled by modifications to its 5' packaging sequences, which facilitates purification of the viral particle from the helper virus.
    Type: Grant
    Filed: August 25, 1997
    Date of Patent: December 14, 1999
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: James M. Wilson, Krishna J. Fisher, Shu-Jen Chen, Matthew Weitzman