Abstract: The invention includes methods and apparatus for separating mutations, especially rare and unknown mutations, using heteroduplex binding proteins. Nucleic acids may optionally be nicked at or near the mutation in order to promote heteroduplex binding protein recognition and binding. In particular, using the disclosed methods, it is possible to separate heteroduplexed nucleic acid strand pair from homoduplexed nucleic acid strand pairs having similar sequences and being at a much higher concentration. Once the heteroduplexed nucleic acids are isolated and recovered, it is straightforward to analyze the sequences of the heteroduplexed nucleic acids, e.g., using sequencing or hybrid assays.

Abstract: The invention includes methods and apparatus for separating mutations, especially rare and unknown mutations, using heteroduplex binding proteins. Nucleic acids may optionally be nicked at or near the mutation in order to promote heteroduplex binding protein recognition and binding. In particular, using the disclosed methods, it is possible to separate heteroduplexed nucleic acid strand pair from homoduplexed nucleic acid strand pairs having similar sequences and being at a much higher concentration. Once the heteroduplexed nucleic acids are isolated and recovered, it is straightforward to analyze the sequences of the heteroduplexed nucleic acids, e.g., using sequencing or hybrid assays.

Abstract: A method for estimating blood pressure using a blood flow occlusion system applied to an artery includes receiving from a first sensor a sensed signal; processing at a processor the sensed signal to detect beats in a pulsatile signal; determining validity of the detected beats; storing the detected beats and data associated with the detected beats in the sensed signal as the pressure applied to the artery by the blood flow occlusion system deflates towards a level below a nominal level; determining baseline beat characteristics; evaluating the stored beats and associated data to detect change in beat characteristics as compared to the baseline beat characteristics; selecting a beat before the detected change in the beat characteristic as the last beat indicating the onset of the diastolic blood pressure for the artery; determining a value of the applied pressure at the last beat as the diastolic blood pressure for the artery.

Abstract: An attitude sensor system with automatic bias correction having a primary attitude sensor wherein the primary attitude sensor comprises at least one accelerometer and an auxiliary sensor system configured to automatically estimate a bias of the accelerometer of the primary attitude sensor such that the resulting error is removed from an output of the attitude sensor system.

Abstract: The invention includes methods and apparatus for separating mutations, especially rare and unknown mutations, using heteroduplex binding proteins. Nucleic acids may optionally be nicked at or near the mutation in order to promote heteroduplex binding protein recognition and binding. In particular, using the disclosed methods, it is possible to separate heteroduplexed nucleic acid strand pair from homoduplexed nucleic acid strand pairs having similar sequences and being at a much higher concentration. Once the heteroduplexed nucleic acids are isolated and recovered, it is straightforward to analyze the sequences of the heteroduplexed nucleic acids, e.g., using sequencing or hybrid assays.

Abstract: The invention includes methods and apparatus for separating mutations, especially rare and unknown mutations, using heteroduplex binding proteins. Nucleic acids may optionally be nicked at or near the mutation in order to promote heteroduplex binding protein recognition and binding. In particular, using the disclosed methods, it is possible to separate heteroduplexed nucleic acid strand pair from homoduplexed nucleic acid strand pairs having similar sequences and being at a much higher concentration. Once the heteroduplexed nucleic acids are isolated and recovered, it is straightforward to analyze the sequences of the heteroduplexed nucleic acids, e.g., using sequencing or hybrid assays.

Abstract: A method for detecting arrhythmia, including receiving, via at least one motion sensor, channels of raw motion signals for a user; monitoring the channels for motion activity; generating segments from the raw motion signals; determining heartbeat event locations from the generated segments; performing false alarm detection on the raw motion signals and heartbeat event locations to generated refined abnormal candidates.

Abstract: A method for event detection in a user-wearable device includes receiving, from a first sensor implemented in the user-wearable device, photoplethysmogram (PPG) signals; processing, at a processor, the PPG signals to obtain PPG signal samples; detecting, at the processor, beats in the PPG signal samples; dividing the PPG signal samples into PPG signal segments; extracting at least one inter-beat interval (IBI) feature in each PPG signal segment; classifying, at the processor, each PPG signal segment using the extracted IBI feature associated with the PPG signal segment and using a machine learning model; in response to the classifying, generating, at the processor, an event prediction result for the PPG signal segment based on the extracted IBI feature; and displaying the event prediction result at the user-wearable device. In another embodiment, the method further includes extracting morphology based features.

Abstract: A method for detecting arrhythmia, including receiving, via at least one motion sensor, channels of raw motion signals for a user; monitoring the channels for motion activity; generating segments from the raw motion signals; determining heartbeat event locations from the generated segments; performing false alarm detection on the raw motion signals and heartbeat event locations to generated refined abnormal candidates.

Abstract: A method for estimating blood pressure using a blood flow occlusion system applied to an artery includes receiving from a first sensor a sensed signal; processing at a processor the sensed signal to detect beats in a pulsatile signal; determining validity of the detected beats; storing the detected beats and data associated with the detected beats in the sensed signal as the pressure applied to the artery by the blood flow occlusion system deflates towards a level below a nominal level; determining baseline beat characteristics; evaluating the stored beats and associated data to detect change in beat characteristics as compared to the baseline beat characteristics; selecting a beat before the detected change in the beat characteristic as the last beat indicating the onset of the diastolic blood pressure for the artery; determining a value of the applied pressure at the last beat as the diastolic blood pressure for the artery.

Abstract: The invention includes methods and apparatus for separating mutations, especially rare and unknown mutations, using heteroduplex binding proteins. Nucleic acids may optionally be nicked at or near the mutation in order to promote heteroduplex binding protein recognition and binding. In particular, using the disclosed methods, it is possible to separate heteroduplexed nucleic acid strand pair from homoduplexed nucleic acid strand pairs having similar sequences and being at a much higher concentration. Once the heteroduplexed nucleic acids are isolated and recovered, it is straightforward to analyze the sequences of the heteroduplexed nucleic acids, e.g., using sequencing or hybrid assays.

Abstract: An attitude sensor system with automatic bias correction having a primary attitude sensor wherein the primary attitude sensor comprises at least one accelerometer and an auxiliary sensor system configured to automatically estimate a bias of the accelerometer of the primary attitude sensor such that the resulting error is removed from an output of the attitude sensor system.

Abstract: A method for event detection in a user-wearable device includes receiving, from a first sensor implemented in the user-wearable device, photoplethysmogram (PPG) signals; processing, at a processor, the PPG signals to obtain PPG signal samples; detecting, at the processor, beats in the PPG signal samples; dividing the PPG signal samples into PPG signal segments; extracting at least one inter-beat interval (IBI) feature in each PPG signal segment; classifying, at the processor, each PPG signal segment using the extracted IBI feature associated with the PPG signal segment and using a machine learning model; in response to the classifying, generating, at the processor, an event prediction result for the PPG signal segment based on the extracted IBI feature; and displaying the event prediction result at the user-wearable device. In another embodiment, the method further includes extracting morphology based features.

Abstract: A method of operating a drone security and entertainment system includes: engaging a drone with a base; receiving signals from at least one sensor remote from the drone vehicle and base; detecting activity; disengaging the drone vehicle from the base; traveling by the drone vehicle; collecting, by the drone vehicle, data including at least one of video, audio, and sensor data; and transmitting, by the drone, the collected data. A security system includes: a base configured to house and charge a drone vehicle; a drone vehicle configured to engage with the base; and at least one sensor in electrical communication with the drone vehicle, wherein the drone is configured for: receiving signals from the at least one sensor; detecting activity; disengaging from the base; traveling; collecting data including at least one of video, audio, and sensor data; and transmitting the collected data.

Abstract: An attitude sensor system with automatic bias correction having a primary attitude sensor wherein the primary attitude sensor comprises at least one accelerometer and an auxiliary sensor system configured to automatically estimate a bias of the accelerometer of the primary attitude sensor such that the resulting error is removed from an output of the attitude sensor system.

Abstract: The invention discloses methods and apparatus for characterizing trace nucleic acids that are biomarkers for disease. The methods and apparatus provide increased sensitivity to such trace nucleic acids, and allow analysis of nucleic acids present in a sample at only 0.01% of the wild-type sequences. The methods and apparatus are also designed for straightforward multiplexing, thus allowing pooling of clinical samples.

Abstract: The invention generally relates to methods of assessing an individual's risk of developing a disease associated with accumulation of DNA mutations by determining the mutation burden in their circulating cell-free nucleic acid relative to a reference sequence. The invention further relates to establishing a score indicative of the individual's risk by assessing the individual's mutation burden against a mutation burden continuum containing various thresholds associated with different degrees of risk. The reference sequence and the continuum may be constructed from a variety of sources. In certain aspects, methods of the invention relate to compilation of a database of mutation burdens for individuals along with population characteristics for each individual.

Abstract: The invention discloses methods and apparatus for characterizing trace nucleic acids that are biomarkers for disease. The methods and apparatus provide increased sensitivity to such trace nucleic acids, and allow analysis of nucleic acids present in a sample at only 0.01% of the wild-type sequences. The methods and apparatus are also designed for straightforward multiplexing, thus allowing pooling of clinical samples.

Abstract: A mounting system, comprising an insertion component configured to be partially inserted into but not through a hole in a first panel of a wall assembly with an elongated anchor having a hub and at least one anchor tab. An elastic holding member is configured to connect the insertion component and the anchor and the anchor located on a first side of a first panel is configured to be inserted through the insertion component opening defining the hole in the first panel. The holding member pulls the insertion component and the anchor toward each other when the insertion component and the anchor are located on opposite sides of the first panel and separated by approximately a first panel thickness.

Abstract: According to one embodiment, described herein is a wall anchor system includes an insert that is positionable within a hole in a wall. The wall anchor system further includes an anchor that is insertable into and passable through the insert. Additionally, the wall anchor system includes an elastic member that couples the insert and anchor. The insert and anchor remain coupled via the elastic member as the anchor is inserted into and passes through the insert.