Abstract: A method for sharing digital content includes determining whether a first computing device is physically located within a defined geographical area, if the first computing device is physically located within the defined geographical area, providing access of shareable digital content to the first computing device, instantiating a tethering object associated with the shareable digital content, the tethering object including at least a first endpoint at the first computing device and a second endpoint at a second computing device remote from the first computing device, and providing access of at least a portion of the shareable digital content, via the tethering object, to the second endpoint at the second computing device remote from the first computing device. Other example methods and computer systems for implementing content sharing methods are also disclosed.

Abstract: Methods for diagnosis of cancer or other physiological conditions using cDNA as sentinel endpoints are disclosed.

Abstract: Methods for diagnosis of one or more physiological conditions using cfDNAs are disclosed. One embodiment of the invention is the computer implemented analysis of mapped circulating cell-free DNA fragment endpoint locations using a hidden Markov model to detect the presence of absence of cancer in a test subject. Another embodiment is a system for implementing the analysis of circulating cell-free DNA to detect the presence of absence of cancer using a hidden Markov model.

Abstract: Provided herein are compounds, methods, and compositions for use in determining the cellular origin of circulating cell-free DNA.

Abstract: Methods for diagnosis of cancer or other physiological conditions using cfDNA as sentinel endpoints are disclosed.

Abstract: Methods for diagnosis of one or more physiological conditions using cfDNAs are disclosed. One embodiment of the invention is the computer implemented analysis of mapped circulating cell-free DNA fragment endpoint locations using a hidden Markov model to detect the presence of absence of cancer in a test subject. Another embodiment is a system for implementing the analysis of circulating cell-free DNA to detect the presence of absence of cancer using a hidden Markov model.

Abstract: Method for diagnosis of one or more physiological conditions with probabilistic methods using cfDNAs are disclosed.

Abstract: Provided herein are compounds, methods, and compositions for use in determining the cellular origin of circulating cell-free DNA.

Abstract: Disclosed is a method for using cell-free DNA (cfDNA) to diagnose certain conditions in a subject. Specifically, the method comprising: isolating a plurality of cfDNA fragments from a biological sample from the subject; sequencing at least a portion of the plurality of cfDNA fragments; mapping a plurality of cfDNA fragments to a reference genome; assigning to each of a plurality of genomic positions a first value corresponding to the number of cfDNA fragments having their leftmost endpoint at said position and a second value corresponding to the number of cfDNA fragment having their rightmost endpoint at said position; comparing the first value and the second value from the subject to corresponding values in a reference dataset from one or more reference subjects; and identifying a probability of the condition in the subject based on the correlation of the subject's first value and second value to the corresponding values.