Patents by Inventor Matthew Wortman

Matthew Wortman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Small-molecule inhibitors targeting G-protein-coupled Rho guanine nucleotide exchange factors
    Patent number: 9951024
    Abstract: Provided are inhibitors of Rho GTPase activation, and, in particular, compounds that inhibit RhoA activation by an RhoGEF. Also provided are related pharmaceutical compositions and methods. Also provided are methods of inhibiting Rho GTPase activation. Also provided are methods of screening for compounds that inhibit Rho GTPase activation by a RhoGEF.
    Type: Grant
    Filed: July 7, 2017
    Date of Patent: April 24, 2018
    Assignees: Children's Hospital Medical Center, Univeristy of Cincinnati
    Inventors: Yi Zheng, Matthew Wortman
  • Methods for modulating function of proliferating cell nuclear antigen (PCNA) and treating cancer with PCNA-targeting compounds
    Patent number: 9895363
    Abstract: Pharmaceutical compositions and methods for inhibiting cell growth, modulating function of PCNA, treating prostate cancer, and enhancing PCNA trimer formation are disclosed. The methods include administering an effective amount of a compound of Formula (I): (a representative image), or an effective amount of a specific compound of Formula (II): (a representative image).
    Type: Grant
    Filed: September 8, 2011
    Date of Patent: February 20, 2018
    Assignee: University of Cincinnati
    Inventors: Zhongyun Dong, Matthew Wortman, Zonqing Tan, Kelsey Dillehay
  • SMALL- MOLECULE INHIBITORS TARGETING G-PROTEIN-COUPLED RHO GUANINE NUCLEOTIDE EXCHANGE FACTORS
    Publication number: 20170349553
    Abstract: Provided are inhibitors of Rho GTPase activation, and, in particular, compounds that inhibit RhoA activation by an RhoGEF. Also provided are related pharmaceutical compositions and methods. Also provided are methods of inhibiting Rho GTPase activation. Also provided are methods of screening for compounds that inhibit Rho GTPase activation by a RhoGEF.
    Type: Application
    Filed: July 7, 2017
    Publication date: December 7, 2017
    Inventors: Yi Zheng, Matthew Wortman
  • SMALL-MOLECULE INHIBITORS TARGETING G-PROTEIN-COUPLED RHO GUANINE NUCLEOTIDE EXCHANGE FACTORS
    Publication number: 20160083353
    Abstract: Provided are inhibitors of Rho GTPase activation, and, in particular, compounds that inhibit RhoA activation by an RhoGEF. Also provided are related pharmaceutical compositions and methods. Also provided are methods of inhibiting Rho GTPase activation. Also provided are methods of screening for compounds that inhibit Rho GTPase activation by a RhoGEF.
    Type: Application
    Filed: January 28, 2014
    Publication date: March 24, 2016
    Inventors: Yi Zheng, Matthew Wortman
  • Identification Of PCNA Targeting Compounds For Cancer Therapy And PCNA Function Regulation
    Publication number: 20140018385
    Abstract: Pharmaceutical compositions and methods for inhibiting cell growth, modulating function of PCNA, treating prostate cancer, and enhancing PCNA trimer formation are disclosed.
    Type: Application
    Filed: September 8, 2011
    Publication date: January 16, 2014
    Applicant: UNIVERSITY OF CINCINNATI
    Inventors: Zhongyun Dong, Matthew Wortman, Zonqing Tan, Kelsey Dillehay