Patents by Inventor Matthew Zhao

Matthew Zhao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystalline forms of an inhibitor of 11-?-hydroxysteroid dehydrogenase type 1
    Patent number: 7875642
    Abstract: Novel crystalline salts of 3-[1-(4-chlorophenyl)-trans-3-fluorocyclobutyl]-4,5-dicyclopropyl-r-4H-1,2,4-triazole are potent inhibitors of 11?-hydroxysteroid dehydrogenase Type 1 and are useful for the treatment of conditions associated with Metabolic Syndrome as well as cognitive impairment. The invention also relates to pharmaceutical compositions containing these novel salts, processes to prepare these salts and their pharmaceutical compositions as well as uses thereof for the treatment of Type 2 diabetes, hyperglycemia, obesity, dyslipidemia, hypertension, and cognitive impairment.
    Type: Grant
    Filed: January 21, 2005
    Date of Patent: January 25, 2011
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Yuri Bereznitski, Mark A. Huffman, Joseph E. Lynch, Matthew Zhao
  • Novel crystalline forms of an inhibitor of 11-beta-hydroxysteroid dehydrogenase type 1
    Publication number: 20090186928
    Abstract: Novel crystalline salts of 3-[1-(4-chlorophenyl)-trans-3-fluorocyclobutyl]-4,5-dicyclopropyl-r-4H-1,2,4-triazole are potent inhibitors of 11?-hydroxysteroid dehydrogenase Type 1 and are useful for the treatment of conditions associated with Metabolic Syndrome as well as cognitive impairment. The invention also relates to pharmaceutical compositions containing these novel salts, processes to prepare these salts and their pharmaceutical compositions as well as uses thereof for the treatment of Type 2 diabetes, hyperglycemia, obesity, dyslipidemia, hypertension, and cognitive impairment.
    Type: Application
    Filed: January 21, 2005
    Publication date: July 23, 2009
    Inventors: Yuri Bereznitski, Mark A. Huffman, Joseph E. Lynch, Matthew Zhao