Abstract: A micromechanical rate-of-rotation sensor set-up, including a first rate-of-rotation sensor device capable of being driven rotationally by a driving device via a drive frame device, so as to oscillate about a first axis, and is for measuring a first outer rate of rotation about a second axis and a second outer rate of rotation about a third axis; and a second rate-of-rotation sensor device capable of being driven by the driving device via the drive frame device, so as to oscillate linearly along the second axis, and is for measuring a third outer rate of rotation about the first axis. The first rate-of-rotation sensor device is connected to the second rate-of-rotation sensor device by the drive frame device. The drive frame device includes a first and second drive frame, which may be driven by the driving device in phase opposition, along the third axis, in an oscillatory manner.

Abstract: Summarizing the invention, a sensing element for monitoring the state of a single-use sterilizable element such as a single-use bioreactor, wherein the state of the single-use sterilizable element is determined by at least one environmental condition is provided. The sensing element comprises: a variable component having at least one physical property that is configured to change in response to the at least one environmental condition and/or a change thereof, wherein the variable component comprises a sensing material with changing absorption characteristics for electromagnetic radiation configured to change in response to the at least one environmental condition and/or a change thereof.

Abstract: A sparging device, especially for use in a bioprocess, including a medium chamber and at least one gas chamber. The gas chamber at least partially surrounds the medium chamber, or the medium chamber at least partially surrounds the gas chamber. The medium chamber and the gas chamber are separated from each other by a wall. The wall has a plurality of through-holes or is composed of a porous material, such as a membrane or a porous ceramic. The sparging device further includes at least one gas inlet port opening into the gas chamber for inflow of gas.

Abstract: A bioprocessing installation comprising a reservoir tank, one or more fluid lines, one or more receiving containers and an electronic control unit. The fluid line fluidically connects the reservoir tank to a receiving container. The liquid biological medium can be transferred from the reservoir tank through the fluid line into the at least one receiving container. The bioprocessing installation comprises a sensor arrangement with at least one gas bubble sensor, which sensor arrangement is configured to detect one or more gas bubbles or foam or separated phases in the liquid biological medium by a gas bubble sensor and to generate one or more corresponding sensor signals, and the electronic control unit is configured to monitor the transfer of the liquid biological medium from the reservoir tank in the direction of the at least one receiving container based on the sensor signals generated by the sensor arrangement.

Abstract: A container for storing, mixing and/or cultivating a medium, in particular a bioreactor for a medium, comprises a line system as a discharge line, feed line and/or bypass line of the bioreactor. The system can comprise a line body formed as a single piece for a medium to flow therethrough. The has a first and a second connection region for connecting in particular to the container and/or the line system and at least a first and a second coupling apparatus in the region between the connection regions.

Abstract: A sensor positioning system for a bioprocess engineering unit, wherein a container is provided for receiving a biological medium which, when installed, extends in the axial direction from an upper container end to a lower container end, wherein a holder is provided for holding the container when installed, wherein a sensor is provided for fixing to the container. A positioning aid device for positioning the sensor to be fixed is provided on the container, the positioning aid device has a positioning aid that can be applied directly to or near the container on the holder, which can be brought into different vertical positions and/or circumferential positions relative to at least one reference point provided on the container and/or holder, and the positioning aid device has a technical storage medium or analog print medium with an allocation list.

Abstract: A device for compensating short-term pressure or volume fluctuations of a medium in a continuously managed biopharmaceutical process including a receiving space in fluid communication with a process line through which a medium flows, an equalizing space, which is separated from the receiving space by a deflectable element, and a counter-pressure mechanism in the equalizing space for applying a counter-pressure to the deflectable element towards the receiving space. A method of compensating short-term pressure or volume fluctuations of a medium in a continuously managed biopharmaceutical process including providing a receiving space in fluid communication with a process line through which a medium flows, receiving an excess amount of the medium flowing into the receiving space, charging an energy storage device by the medium flowing into the receiving space, and expelling at least part of the excess amount if the pressure or flow rate falls below a set amount.

Abstract: Summarizing the invention, a sensing element for monitoring the state of a single-use sterilizable element such as a single-use bioreactor, wherein the state of the single-use sterilizable element is determined by at least one environmental condition is provided. The sensing element comprises: a variable component having at least one physical property that is configured to change in response to the at least one environmental condition and/or a change thereof, wherein the variable component comprises a sensing material with changing absorption characteristics for electromagnetic radiation configured to change in response to the at least one environmental condition and/or a change thereof.

Abstract: A tread for a tire includes a first circumferential main groove, a second circumferential main groove, and a third circumferential main groove. The first, second, and third circumferential main grooves together define a first shoulder rib, a first intermediate rib, a second intermediate rib, and a second shoulder rib. The second shoulder rib has a plurality of first linear, lateral grooves circumferentially alternating with a plurality of second linear, lateral grooves and a plurality of double blind lateral sipes disposed circumferentially midway between each adjacent first lateral groove and second lateral groove. The first and second lateral gooves extend both axially and circumferentially toward the third circumferential main groove. The first lateral grooves terminate nearer the third circumferential main groove than the second lateral grooves.

Abstract: A tread for a tire includes a first circumferential main groove, a second circumferential main groove, and a third circumferential main groove. The first, second, and third circumferential main grooves together define a first shoulder rib, a first intermediate rib, a second intermediate rib, and a second shoulder rib. The third circumferential main groove includes a plurality of connecting bridges spaced circumferentially within the third circumferential main groove and axially joining the second intermediate rib and second shoulder rib.

Abstract: A tread for a tire includes a first circumferential main groove, a second circumferential main groove, and a third circumferential main groove. The first, second, and third circumferential main grooves together define a first shoulder rib, a first intermediate rib, a second intermediate rib, and a second shoulder rib. The third circumferential main groove includes a plurality of connecting bridges spaced circumferentially within the third circumferential main groove and axially joining the second intermediate rib and second shoulder rib.

Abstract: The present invention is directed to an article of manufacture having a wire-reinforced component comprising (A) a metallic wire; and (B) a rubber composition contacting the wire, the rubber composition comprising (1) a diene based elastomer; and (2) a tin(II) carboxylate salt.

Abstract: The invention relates to a tire with a tread of a cap/base construction comprised of a two-ply (dual layered) tread cap rubber layer comprised of a combination of an outer tread cap layer and an inner tread cap layer together with an underlying tread base rubber layer which underlies the two-ply tread cap layer. The tread cap layer is of a lug and groove configuration with at least a portion of the grooves extending through the outer tread cap layer into the inner tread cap layer without extending to the tread base rubber layer. The outer tread cap rubber layer is comprised of a carbon black-rich rubber composition to promote dry traction for the tread running surface. The inner tread cap layer is comprised of a softer silica-rich rubber composition to promote wet traction for tread running surface as the outer tread cap layer wears away to expose the softer inner tread cap layer.