Abstract: A feedback mechanism for an injection device that is configured to deliver a medicament to a user is described. The feedback mechanism comprises an actuator and a fluid chamber having a restricted outlet. The actuator is adapted to urge fluid from the fluid chamber through the restricted outlet. The feedback mechanism also has an indicator that is adapted to provide feedback to the user after a predetermined volume of fluid has passed from the fluid chamber through the restricted outlet during use of the injection device.

Abstract: An automated production line for the production of ophthalmic lenses comprises: a production line front end (1) comprising: a first injection-molding machine (10) and a second injection-molding machine (12) a casting module (14) comprising a filling station (144) and a capping station (145); a stacking module (15) and a curing module (16); a destacking module (17) and a demolding and delensing module a production line back end (2) comprising: a scalable treatment module (20) comprising a number of liquid baths for a liquid bath treatment of the cured lenses (CL) carried by the treatment carrier tray (200) to obtain the ophthalmic lenses, wherein the number of liquid baths are reduced or increased pending on the number of ophthalmic lenses concurrently produced by the production lines.

Abstract: An inverter with a rated power of at least 3 kVA includes a first assembly which includes a first printed circuit board and a DC/AC converter stage, and a second assembly which includes a second printed circuit board and an EMC filter for the DC/AC converter stage. The first printed circuit board is mounted on a heat sink and lies substantially flat on the heat sink, and the DC/AC converter stage has converter components which comprise power semiconductors, chokes and link circuit capacitors. The chokes and the link circuit capacitors are arranged together on one side of the first printed circuit board, and the heat sink is arranged on the opposite side of the first printed circuit board, and the chokes and/or the power semiconductors are thermally connected to the heat sink via the first printed circuit board and a thermally conductive material arranged between the first printed circuit board and the heat sink.

Abstract: An automated production line for the production of ophthalmic lenses comprises: a production line front end (1) comprising: a first injection-molding machine (10) and a second injection-molding machine (12) a casting module (14) comprising a filling station (144) and a capping station (145); a stacking module (15) and a curing module (16); a destacking module (17) and a demolding and delensing module a production line back end (2) comprising: a scalable treatment module (20) comprising a number of liquid baths for a liquid bath treatment of the cured lenses (CL) carried by the treatment carrier tray (200) to obtain the ophthalmic lenses, wherein the number of liquid baths are reduced or increased pending on the number of ophthalmic lenses concurrently produced by the production lines.

Abstract: A work machine includes a moving boom, an ultra-wideband system (UWB) having one UWB tag and a number of UWB anchors, a marking apparatus that can be handled by a user and can be operated by the user, and a control unit. The UWB tag is mounted on the marking apparatus. The control unit is designed so as, when the marking apparatus is operated, to store a position of the UWB tag ascertained by way of the UWB system at the time of the operation and to control the operation of the mobile work machine on the basis of the ascertained position.

Abstract: A forming tool and a forming method for producing an overpressure predetermined breaking point in a battery cover by deformation. The forming tool has a stamping tool and a die tool and an optional hold-down arrangement. On the die tool a support surface is provided for the battery cover to be deformed to form a forming cavity in the die tool in a depressed manner. On the stamping tool a stamp part and a ring-shaped stamp part is provided corresponding to a bead to be created in the battery cover in the cross-section. During deformation of the battery cover the stamping tool is pressed in the battery cover, whereby material of the battery cover flows into the forming cavity. Thereby the stamping tool is approached to the forming cavity in a manner such that the remaining distance corresponds to a minimum wall thickness at the overpressure predetermined breaking point.

Abstract: Supporting construction (10) for a working machine comprising a mast, having a supporting leg box (12), which is open to a front side (16), and having a supporting leg (20) which is mounted displaceably in the longitudinal direction for moving between a completely retracted position and a position in which it is completely extended by a maximum extension length (A), wherein the supporting leg box (12) has, in the region of the open front side (16), a first load introduction device (30) and, at a given distance (D) from the front side (16), within the supporting leg box, a single second load introduction device (32) having at least one supporting surface (34), and wherein the supporting leg (20) has a reinforcing element (36) which extends substantially along a length (L) of the supporting leg (20) and which is designed to bear on the at least one supporting surface (34) of the single second load introduction device (32).

Abstract: The subject of the present invention is a frame (12) with a boom pedestal (17) for mounting a thick matter distribution boom (20) and having a support profile (13) for receiving and transmitting a force flow generated by the weight force of the thick matter distribution boom (20). The boom pedestal (17) has two tab elements (21, 22) which project downwards from the boom pedestal (17) and which each have a through-hole (23, 24), wherein the support profile (13) comprises a bolt receptacle (14) aligned with the through-holes, and wherein a bolt element (15) for connecting the boom pedestal (17) to the support profile (13) is guided through the through-holes (23, 24) and the bolt receptacle (14). The invention further relates to a corresponding thick matter pump equipped with said frame. The transportation effort required in production can be reduced by means of the bolt connection.

Abstract: A wind tunnel for a motor vehicle, with a fan, a test section, through which an air stream generated by the fan can flow, a recording device for recording different motor vehicles within the test section, and a testing device for determining aerodynamic characteristics of the motor vehicle. The wind tunnel also includes an optical sensing device for sensing an outer contour of the motor vehicle recorded by the recording device, an evaluating unit and a linking unit. The evaluating unit determines a vehicle configuration from the outer contour of the motor vehicle sensed by the optical sensing device. The linking unit links the vehicle configuration of the motor vehicle determined by the evaluating unit with the test results determined by the testing device.

Abstract: An automated production line for the production of ophthalmic lenses comprises: a production line front end (1) comprising: a first injection-molding machine (10) and a second injection-molding machine (12) a casting module (14) comprising a filling station (144) and a capping station (145); a stacking module (15) and a curing module (16); a destacking module (17) and a demolding and delensing module a production line back end (2) comprising: a scalable treatment module (20) comprising a number of liquid baths for a liquid bath treatment of the cured lenses (CL) carried by the treatment carrier tray (200) to obtain the ophthalmic lenses, wherein the number of liquid baths are reduced or increased pending on the number of ophthalmic lenses concurrently produced by the production lines.

Abstract: An automated production line for the production of ophthalmic lenses comprises: a production line front end (1) comprising: a first injection-molding machine (10) and a second injection-molding machine (12) a casting module (14) comprising a filling station (144) and a capping station (145); a stacking module (15) and a curing module (16); a destacking module (17) and a demolding and delensing module a production line back end (2) comprising: a treatment module (20), an inspection module (21), wherein the production line has the easy adaptability of curing times and temperatures, and in the capability of using different treatment liquids and treatment times in the extraction module to achieve the product flexibility.

Abstract: An automated production line for the production of ophthalmic lenses comprises: a production line front end (1) comprising: a first injection-molding machine (10) and a second injection-molding machine (12) a casting module (14) comprising a filling station (144) and a capping station (145); a stacking module (15) and a curing module (16); a destacking module (17) and a demolding and delensing module a production line back end (2) comprising: a scalable treatment module (20); an inspection module (21); a primary packaging module (22), Wherein the first and second injection-molding machines allow for a quick exchange of the tooling plates used in the injection molding machine without the need to decrease the temperature of the injection molding machine by pre-configured tooling plates.

Abstract: An automated production line for the production of ophthalmic lenses comprises: a production line front end comprising: a first and a second injection-molding machine, a casting module, a filling station and a capping station, a stacking module and a curing module, a destacking module and a demolding and delensing module a production line back end comprising: a treatment module, an inspection module, wherein self-driving shuttles in the inspection module can form a queue and act as a buffer for the primary packaging module if an interruption of the primary packaging module and variations of the cycle time in the primary packaging module are buffered so that the extraction module is able to operate largely independently from the upstream and downstream components of the manufacturing line.

Abstract: An automated production line for the production of ophthalmic lenses comprises: a production line front end (1) comprising: a first injection-molding machine (10) and a second injection-molding machine (12) a casting module (14) comprising a filling station (144) and a capping station (145); a stacking module (15) and a curing module (16); a destacking module (17) and a demolding and delensing module a production line back end (2) comprising: an inspection module (21); Wherein the inspection module comprising a rail system in which self-driving shuttles carrying the inspection cuvettes are arranged on a closed-loop rail, wherein the rail system can be adapted to the available space in the production plant/hall using curves and straight portions in the manner known from a model railway.

Abstract: A wind tunnel for a motor vehicle, with a fan, a test section, through which an air stream generated by the fan can flow, a recording device for recording different motor vehicles within the test section, and a testing device for determining aerodynamic characteristics of the motor vehicle. The wind tunnel also includes an optical sensing device for sensing an outer contour of the motor vehicle recorded by the recording device, an evaluating unit and a linking unit. The evaluating unit determines a vehicle configuration from the outer contour of the motor vehicle sensed by the optical sensing device. The linking unit links the vehicle configuration of the motor vehicle determined by the evaluating unit with the test results determined by the testing device.

Abstract: The present disclosure relates generally to polypeptides, cells, compositions and methods for enhancing immune function, and in particular the immune function of T cells, such as CD8+ T cells. More particularly, the present invention relates to modified DNAM-1 polypeptides, T cells expressing recombinant and/or modified DNAM-1, and methods of using these cells in adoptive T cell transfer, such as for the treatment of cancer or infection. The disclosure also relates to methods for preparing T cells with enhanced immune function; methods for preparing T cells for adoptive cell therapy; methods for assessing the immune function of T cells in a subject or cell population; methods for predicting the responsiveness of a subject with cancer to cancer therapy; and methods for predicting the survival or survival time of a subject with cancer.

Abstract: A forming tool and a forming method for producing an overpressure predetermined breaking point in a battery cover by deformation. The forming tool has a stamping tool and a die tool and an optional hold-down arrangement. On the die tool a support surface is provided for the battery cover to be deformed to form a forming cavity in the die tool in a depressed manner. On the stamping tool a stamp part and a ring-shaped stamp part is provided corresponding to a bead to be created in the battery cover in the cross-section. During deformation of the battery cover the stamping tool is pressed in the battery cover, whereby material of the battery cover flows into the forming cavity. Thereby the stamping tool is approached to the forming cavity in a manner such that the remaining distance corresponds to a minimum wall thickness at the overpressure predetermined breaking point.

Abstract: A coupling for connection of an encoder to an electrical machine includes an encoder shaft end piece for coupling to a shaft of the encoder, and a machine shaft end piece for coupling to a shaft of the electrical machine. At least one of the end pieces has a carrier which is formed with a cavity filled with granular material, preferably steel powder, to effect a dampening of vibrations and impacts.

Abstract: A digital cockpit display (1) for a vehicle has a display device (2) with electronic display elements (3a-3n) arranged in the form of a matrix and by means of which information can be visualized. A control device (4) enables control of the display elements (3a-3n) to visualize the information. The display device (2) has micro-electromechanical actuators (5a-5n) that are connected to the display elements (3a-3n) and are selectively controllable by the control device (4) so that they initiate a linear movement of the display elements (3a-3n) between a retracted position in which a longitudinal extension of the microelectronic actuators (5a-5n) is minimal and a fully extended position in which the longitudinal extension of the microelectronic actuators (5a-5n) is maximal.

Abstract: An air directing apparatus for a motor vehicle includes a basic body configured to direct an air flow occurring during operation of the motor vehicle as intended. The basic body has a height that changes continuously in a transverse direction of the motor vehicle.