Patents by Inventor Matthias Eckhardt

Matthias Eckhardt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Imidazopyridazinediones, Their Preparation And Their Use As Pharmaceutical Compositions
    Publication number: 20070142383
    Abstract: The invention relates to substituted imidazopyridazinediones of general formula wherein R1 to R4 are defined as in claim 1, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
    Type: Application
    Filed: February 16, 2007
    Publication date: June 21, 2007
    Inventors: Matthias Eckhardt, Frank Himmelsbach, Iris Kauffmann-Hefner, Elke Langkopf, Mohammad Tadayyon, Leo Thomas
  • Piperazin-1-yl and 2-([1,4]diazepan-1-yl)-imidazo[4,5-d]-pyridazin-4-ones, the preparation thereof and their use as pharmaceutical compositions
    Patent number: 7217711
    Abstract: The present invention relates to substituted imidazo[4,5-d]pyridazin-4-ones of general formula wherein R1 to R3 and n are defined as in claims 1 to 8, the tautomers, enantiomers, diastereomers, mixtures thereof and the salts thereof which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
    Type: Grant
    Filed: December 17, 2004
    Date of Patent: May 15, 2007
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Matthias Eckhardt, Norbert Hauel, Frank Himmelsbach, Iris Kauffmann-Hefner, Elke Langkopf, Mohammad Tadayyon, Leo Thomas
  • 2-AMINO-IMIDAZO[4,5-D]PYRIDAZIN-4-ONES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS
    Publication number: 20070088038
    Abstract: The present invention relates to 2-amino-imidazo[4,5-d]pyridazin-4-ones and 2-amino-imidazo[4,5-c]pyridin-4-ones of general formula wherein R1 to R4 and X are defined as in claims 1 to 6, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
    Type: Application
    Filed: December 12, 2006
    Publication date: April 19, 2007
    Inventors: Matthias Eckhardt, Frank Himmelsbach, Elke Langkopf, Norbert Hauel, Mohammad Tadayyon, Leo Thomas
  • Processes for preparing of glucopyranosyl-substituted (ethynyl-benzyl)-benzene derivatives and intermediates thereof
    Publication number: 20070073046
    Abstract: The present invention relates to processes for preparing the compounds of general formula I, wherein the groups R1, R2 and R3 are defined according to claim 1 and to intermediates of said processes.
    Type: Application
    Filed: September 14, 2006
    Publication date: March 29, 2007
    Inventors: Matthias ECKHARDT, Frank Himmelsbach
  • Crystalline forms of 1-chloro-4-(beta-D-glucopyranos-1-yl)-2-[4-ethynyl-benzyl)-benzene, methods for its preparation and the use thereof for preparing medicaments
    Publication number: 20070054867
    Abstract: The invention relates to a crystalline hydrate of 1-chloro-4-(?-D-glucopyranos-1-yl)-2-(4-ethynyl-benzyl)-benzene and to crystalline complexes between 1-chloro-4-(?-D-glucopyranos-1-yl)-2-(4-ethynyl-benzyl)-benzene and a natural amino acid, to methods for the preparation thereof, as well as to uses thereof for preparing medicaments.
    Type: Application
    Filed: September 7, 2006
    Publication date: March 8, 2007
    Inventors: Matthias Eckhardt, Frank Himmelsbach, Tanja Butz, Martin Schuehle, Hans-Juergen Martin
  • Glucopyranosyl-substituted benzyl-benzene derivatives, medicaments containing such compounds, their use and process for their manufacture
    Publication number: 20070049537
    Abstract: Glucopyranosyl-substituted benzyl-benzene derivatives of the general formula I where the groups R1 to R6 as well as R7a, R7b, R7c are defined according to claim 1, including the tautomers, the stereoisomers thereof, the mixtures thereof and the salts thereof. The compounds according to the invention are suitable for the treatment of metabolic disorders.
    Type: Application
    Filed: August 29, 2006
    Publication date: March 1, 2007
    Inventors: Matthias Eckhardt, Frank Himmelsbach, Peter Eickelmann, Leo Thomas
  • Bicyclic imidazole derivatives, the preparation thereof and their use as pharmaceutical compositions
    Patent number: 7183280
    Abstract: The present invention relates to bicyclic imidazole compounds of general formula wherein R1 to R3 and A are defined as in claims 1 to 8, the tautomers, the enantiomers, the stereoisomers, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
    Type: Grant
    Filed: December 21, 2004
    Date of Patent: February 27, 2007
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Frank Himmelsbach, Elke Langkopf, Matthias Eckhardt, Norbert Hauel, Mohammad Tadayyon, Leo Thomas
  • 2-Amino-imidazo[4,5-d]pyridazin-4-ones, their preparation and their use as pharmaceutical compositions
    Patent number: 7179809
    Abstract: The present invention relates to 2-amino-imidazo[4,5-d]pyridazin-4-ones and 2-amino-imidazo[4,5-c]pyridin-4-ones of general formula wherein R1 to R4 and X are defined as in claims 1 to 6, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
    Type: Grant
    Filed: April 8, 2005
    Date of Patent: February 20, 2007
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Matthias Eckhardt, Frank Himmelsbach, Elke Langkopf, Norbert Hauel, Mohammad Tadayyon, Leo Thomas
  • Glucopyranosyl-substituted ((hetero)cycloalkylethynyl-benzyl)-benzene derivatives, medicaments containing such compounds, their use and process for their manufacture
    Publication number: 20070027092
    Abstract: Glucopyranosyl-substituted ((hetero)cycloalkylethynyl-benzyl)-benzene derivatives of the general formula I where the groups R1 to R6 as well as R7a, R7b, R7c are defined according to claim 1, including the tautomers, the stereoisomers thereof, the mixtures thereof and the salts thereof. The compounds according to the invention are suitable for the treatment of metabolic disorders.
    Type: Application
    Filed: July 27, 2006
    Publication date: February 1, 2007
    Inventors: Frank Himmelsbach, Matthias Eckhardt, Peter Eickelmann, Leo Thomas
  • Glucopyranosyl-substituted benzyl-benzene derivatives, medicaments containing such compounds, their use and process for their manufacture
    Publication number: 20070004648
    Abstract: Glucopyranosyloxy-substituted benzyl-benzene derivatives of the general formula I where the groups groups R1, R2, R3a, R3b, R4, R5, R6, X and R7a, R7b, R7c are defined according to claim 1, including the tautomers, the stereoisomers thereof, the mixtures thereof and the salts thereof. The compounds according to the invention are suitable for the treatment of metabolic disorders.
    Type: Application
    Filed: June 29, 2006
    Publication date: January 4, 2007
    Inventors: Frank Himmelsbach, Matthias Eckhardt, Peter Eickelmann, Leo Thomas
  • Processes for preparing of glucopyranosyl-substituted benzyl-benzene derivatives and intermediates therein
    Publication number: 20060258749
    Abstract: The present invention relates to processes for preparing the compounds of general formula I, wherein the groups R1 and R3 are defined according to claim 1. Furthermore this inventions relates to intermediates obtained in these processes.
    Type: Application
    Filed: May 3, 2006
    Publication date: November 16, 2006
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Matthias Eckhardt, Frank Himmelsbach, Xiao-jun Wang, Wenjun Tang, Xiufeng Sun, Li Zhang, Dhileepkumar Krishnamurthy, Christopher Senanayake, Zhengxu Han
  • Crystalline forms of 1-chloro-4-(beta-D-glucopyranos-1-yl)-2-[4-((R)-tetrahydrofuran-3-yloxy)-benzyl]-benzene, a method for its preparation and the use thereof for preparing medicaments
    Publication number: 20060251728
    Abstract: The invention relates to crystalline forms of 1-chloro-4-(?-D-glucopyranos-1-yl)-2-[4-((R)-tetrahydrofuran-3-yloxy)-benzyl]-benzene, to a method for the preparation thereof, as well as to the use thereof for preparing medicaments.
    Type: Application
    Filed: April 21, 2006
    Publication date: November 9, 2006
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Frank Himmelsbach, Sandra Schmid, Hans-Juergen Martin, Matthias Eckhardt, Martin Schuehle
  • XANTHINE DERIVATIVES, THE PREPARATION THEREOF AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS
    Publication number: 20060247226
    Abstract: The present invention relates to substituted xanthines of general formula wherein R1 to R4 are defined as in claim 1, the tautomers and the stereoisomers thereof, mixtures thereof, the prodrugs and the salts thereof which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
    Type: Application
    Filed: July 12, 2006
    Publication date: November 2, 2006
    Inventors: Frank Himmelsbach, Michael Mark, Matthias Eckhardt, Elke Langkopf, Roland Maier, Ralf Lotz
  • Glucopyranosyl-substituted (heteroaryloxy-benzyl)-benzene derivatives, medicaments containing such compounds, their use and process for their manufacture
    Publication number: 20060234953
    Abstract: Glucopyranosyloxy-substituted (heteroaryloxy-benzyl)-benzene compounds of the general formula I where the groups R1 to R6 as well as R7a, R7b, R7c are defined according to claim 1, including the tautomers, the stereoisomers thereof, the mixtures thereof and the salts thereof. The compounds according to the invention are suitable for the treatment of metabolic disorders.
    Type: Application
    Filed: April 13, 2006
    Publication date: October 19, 2006
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Frank Himmelsbach, Matthias Eckhardt, Peter Eickelmann, Leo Thomas
  • Substituted imidazo-pyridinones and imidazo-pyridazinones, the preparation thereof and their use as pharmaceutical compositions
    Patent number: 7109192
    Abstract: The present invention relates to substituted imidazo-pyridinones and imidazo-pyridazinones of general formula wherein R1 to R4 are defined as in claim 1, the tautomers, the stereoisomers, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, particularly an inhibitory effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
    Type: Grant
    Filed: December 2, 2003
    Date of Patent: September 19, 2006
    Assignee: Boehringer Ingelheim Pharma GmbH & Co KG
    Inventors: Norbert Hauel, Frank Himmelsbach, Elke Langkopf, Matthias Eckhardt, Roland Maier, Michael Mark, Mohammad Tadayyon, Iris Kauffmann-Hefner
  • Xanthine derivatives, the preparation thereof and their use as pharmaceutical compositions
    Publication number: 20060205711
    Abstract: The present invention relates to substituted xanthines of general formula wherein R1 to R4 are defined as in claim 1, the tautomers and the stereoisomers thereof, mixtures thereof, the prodrugs and the salts thereof which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
    Type: Application
    Filed: May 22, 2006
    Publication date: September 14, 2006
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Frank Himmelsbach, Michael Mark, Matthias Eckhardt, Elke Langkopf, Roland Maier, Ralf Lotz
  • Glucopyranosyl-substituted ((hetero)arylethynyl-benzyl)-benzene derivatives, medicaments containing such compounds, their use and process for their manufacture
    Publication number: 20060189548
    Abstract: Glucopyranosyl-substituted (hetero)arylethynyl-benzene derivatives of the general formula I where the groups R1 to R6 as well as R7a, R7b, R7c are defined according to claim 1, including the tautomers, the stereoisomers thereof, the mixtures thereof and the salts thereof. The compounds according to the invention are suitable for the treatment of metabolic disorders.
    Type: Application
    Filed: February 22, 2006
    Publication date: August 24, 2006
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Frank Himmelsbach, Matthias Eckhardt, Peter Eickelmann, Leo Thomas, Edward Barsoumian
  • Glucopyranosyl-substituted benzene derivatives, medicaments containing such compounds, their use and process for their manufacture
    Publication number: 20060142210
    Abstract: Glucopyranosyl-substituted benzene derivatives defined according to claim 1, including the tautomers, the stereoisomers thereof, the mixtures thereof and the salts thereof. The compounds according to the invention are suitable for the treatment of metabolic disorders.
    Type: Application
    Filed: December 15, 2005
    Publication date: June 29, 2006
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Matthias Eckhardt, Frank Himmelsbach, Peter Eickelmann, Leo Thomas, Edward Barsoumian
  • 3-methyl-7-butinyl-xanthines, the preparation thereof and their use as pharmaceutical compositions
    Publication number: 20060079541
    Abstract: The present invention relates to new substituted xanthines of general formula wherein R1, R2 and X are defined as in the claims, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
    Type: Application
    Filed: September 1, 2005
    Publication date: April 13, 2006
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Elke Langkopf, Matthias Eckhardt, Frank Himmelsbach, Mohammad Tadayyon, Leo Thomas, Ralf Lotz
  • D-pyranosyl-substituted phenyl derivatives, medicaments containing such compounds, their use and process for their manufacture
    Publication number: 20060074031
    Abstract: D-pyranosyl-substituted phenyls of general formula I wherein the groups R1 to R5, X, Z and R7a, R7b, R7c are defined as in claim 1, have an inhibiting effect on the sodium-dependent glucose cotransporter SGLT. The present invention also relates to pharmaceutical compositions for the treatment of metabolic disorders.
    Type: Application
    Filed: September 30, 2005
    Publication date: April 6, 2006
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Matthias Eckhardt, Frank Himmelsbach, Peter Eickelmann, Leo Thomas, Edward Barsoumian