Patents by Inventor Matthias Epple
Matthias Epple has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10172807Abstract: The invention refers to a nanoparticle with a diameter which is the maximum in the nanoparticle size distribution, in the range of 10-300 nm, comprising a) a calcium phosphate nanoparticle core a), b) an active ingredient coating b) on the calcium phosphate nanoparticle core a), c) a lactic acid polymer coating c) on the active ingredient coating b), d) a cationic polymer coating d) on the lactic acid polymer coating c) selected from the group of polyethylene-imines, chitosan and human lactoferrin-derived peptides with a length of 14 to 30 amino acids.Type: GrantFiled: May 26, 2015Date of Patent: January 8, 2019Assignee: Evonik Röhm GmbHInventors: Rosario Lizio, Silko Grimm, Hans-Ulrich Petereit, Matthias Epple, Gregor Doerdelmann
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Publication number: 20170333361Abstract: The invention refers to a nanoparticle with a diameter which is the maximum in the nanoparticle size distribution, in the range of 10-300 nm, comprising a) a calcium phosphate nanoparticle core a), b) an active ingredient coating b) on the calcium phosphate nanoparticle core a), c) a lactic acid polymer coating c) on the active ingredient coating b), d) a cationic polymer coating d) on the lactic acid polymer coating c) selected from the group of polyethylene-imines, chitosan and human lactoferrin-derived peptides with a length of 14 to 30 amino acids.Type: ApplicationFiled: May 26, 2015Publication date: November 23, 2017Applicant: Evonik Roehm GmbHInventors: Rosario LIZIO, Silko GRIMM, Hans-Ulrich PETEREIT, Matthias EPPLE, Gregor DOERDELMANN
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Patent number: 8956648Abstract: The present invention provides pharmaceutical photosensitizer-loaded nanoparticle formulations and their methods of preparation for photodynamic therapy, comprising a hydrophobic or hydrophilic photosensitizer, nanoparticulate calcium phosphate and in certain cases auxiliary reagents such as stabilizers. The calcium phosphate-based nanoparticle formulations of the present invention provide excellent storage stability and therapeutically effective amounts of photosensitizer for intravenous or topical administration. In a preferred embodiment, tetrapyrrole derivatives such as porphyrins, chlorins and bacteriochlorins, are the preferred hydrophobic photosensitizers to be formulated in calcium phosphate nanoparticle formulations for photodynamic tumor therapy. Additionally, 5,10,15,20-tetrakis(4-phosphonooxyphenyl)porphine (pTPPP) is a preferred hydrophilic photosensitizer for photodynamic tumor therapy.Type: GrantFiled: December 18, 2009Date of Patent: February 17, 2015Assignee: Biolitec PharmaMarketing LtdInventors: Burkhard Gitter, Susanna Gräfe, Arno Wiehe, Volker Albrecht, Matthias Epple, Janine Schwiertz, Kathirvel Ganesan
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Publication number: 20110257586Abstract: The present invention provides pharmaceutical photosensitizer-loaded nanoparticle formulations and their methods of preparation for photodynamic therapy, comprising a hydrophobic or hydrophilic photosensitizer, nanoparticulate calcium phosphate and in certain cases auxiliary reagents such as stabilizers. The calcium phosphate-based nanoparticle formulations of the present invention provide excellent storage stability and therapeutically effective amounts of photosensitizer for intravenous or topical administration. In a preferred embodiment, tetrapyrrole derivatives such as porphyrins, chlorins and bacteriochlorins, are the preferred hydrophobic photosensitizers to be formulated in calcium phosphate nanoparticle formulations for photodynamic tumor therapy. Additionally, 5,10,15,20-tetrakis(4-phosphonooxyphenyl)porphine (pTPPP) is a preferred hydrophilic photosensitizer for photodynamic tumor therapy.Type: ApplicationFiled: December 18, 2009Publication date: October 20, 2011Applicants: UNIVERSITAT DUISBURG-ESSEN, BIOLITEC AGInventors: Burkhatd Gitter, Susanna Grafe, Arno Wiehe, Volker Albrecht, Matthias Epple, Janine Schwiertz, Kathirvel Ganesan
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Patent number: 7959682Abstract: In order to provide a bone substitution material which enables mechanical stability and long-term in-vivo biocompatibility which can also be used for guided bone healing, the invention provides a method comprising the steps of providing a starting material comprising a mixture of at least a skeleton substance (20) and at least one functional substance, and building up a skeleton from the skeleton substance, thereby producing a profiled body (30), as well as a profiled body (30) containing a skeleton substance (20) and comprising a porous structure (10) with pores (12, 15) being interconnected with each other.Type: GrantFiled: September 30, 2004Date of Patent: June 14, 2011Assignee: ADC Advanced Dental Care GmbH & Co. KGInventors: Matthias Epple, Drazen Tadic
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Patent number: 7866555Abstract: A transport monitoring system is provided for transporting goods that are provided with identification tags. The identification tags store identification data used to identify the goods. The transport device includes a closeable transport unit, at least one reader unit, an evaluation unit and activation unit. The closeable transport unit receives goods that are provided with identification tags. The at least one reader unit emits an inquiry signal to the transport unit in order to read the identification tags when an activation signal for activating the reader unit is received. The at least one reader unit also receives the identification data signals emitted by the identification tags. The evaluation unit is used to evaluate the identification data signals received by the reader unit. The activation unit produces the activating signal for activating the reader unit once the transport unit is closed.Type: GrantFiled: October 7, 2005Date of Patent: January 11, 2011Assignee: Deutsche Telekom AGInventors: Rolf Hermann Schmid, Hartmut Feuchtmueller, Matthias Epple, Alfred Rampf, Hans-Juergen Neuerburg
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Publication number: 20090026263Abstract: A transport monitoring system is provided for transporting goods that are provided with identification tags. The identification tags store identification data used to identify the goods. The transport device includes a closeable transport unit, at least one reader unit, an evaluation unit and activation unit. The closeable transport unit receives goods that are provided with identification tags. The at least one reader unit emits an inquiry signal to the transport unit in order to read the identification tags when an activation signal for activating the reader unit is received. The at least one reader unit also receives the identification data signals emitted by the identification tags. The evaluation unit is used to evaluate the identification data signals received by the reader unit. The activation unit produces the activating signal for activating the reader unit once the transport unit is closed.Type: ApplicationFiled: October 7, 2005Publication date: January 29, 2009Applicant: DEUTSCHE TELEKOM AGInventors: Rolf Hermann Schmid, Hartmut Feuchtmueller, Matthias Epple, Alfred Rampf, Hans-Juergen Neuerburg
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Publication number: 20050163861Abstract: In order to provide a bone substitution material which enables mechanical stability and long-term in-vivo biocompatibility which can also be used for guided bone healing, the invention provides a method comprising the steps of providing a starting material comprising a mixture of at least a skeleton substance (20) and at least one functional substance, and building up a skeleton from the skeleton substance, thereby producing a profiled body (30), as well as a profiled body (30) containing a skeleton substance (20) and comprising a porous structure (10) with pores (12, 15) being interconnected with each other.Type: ApplicationFiled: September 30, 2004Publication date: July 28, 2005Inventors: Matthias Epple, Drazen Tadic