Patents by Inventor Matthias Franzreb
Matthias Franzreb has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11185870Abstract: An apparatus for a selective fractionation of ultrafine particles includes at least three separating columns fluidically connected in series by connecting lines. An infeed is arranged to feed into a connecting line which is arranged upstream of each separating column. Each connecting line comprises an inlet for a suspension of ultrafine particles to be separated and an inlet for at least one additional mobile phase. The inlets are alternately operated. A discharge branches off from a connecting line which is arranged downstream of each separating column. Each connecting line comprises an outlet for a first and a second discharge suspension of the ultrafine particles. The outlets are alternately operated. A control means provides a simultaneous switching of the through-flow switching position of the shutoff valves at the inlets and outlets. At least one magnetic field source for a magnetic field is arranged in each separating column.Type: GrantFiled: February 26, 2018Date of Patent: November 30, 2021Assignee: KARLSRUHER INSTITUT FUER TECHNOLOGIEInventors: Matthias Franzreb, Moritz Ebeler, Andre Tschoepe
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Publication number: 20200108401Abstract: An apparatus for a selective fractionation of ultrafine particles includes at least three separating columns fluidically connected in series by connecting lines. An infeed is arranged to feed into a connecting line which is arranged upstream of each separating column. Each connecting line comprises an inlet for a suspension of ultrafine particles to be separated and an inlet for at least one additional mobile phase. The inlets are alternately operated. A discharge branches off from a connecting line which is arranged downstream of each separating column. Each connecting line comprises an outlet for a first and a second discharge suspension of the ultrafine particles. The outlets are alternately operated. A control means provides a simultaneous switching of the through-flow switching position of the shutoff valves at the inlets and outlets. At least one magnetic field source for a magnetic field is arranged in each separating column.Type: ApplicationFiled: February 26, 2018Publication date: April 9, 2020Applicant: KARLSRUHER INSTITUT FUER TECHNOLOGIEInventors: MATTHIAS FRANZREB, MORITZ EBELER, ANDRE TSCHOEPE
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Patent number: 9757767Abstract: The present invention relates to a device, the use thereof and a method for producing highly porous, crystalline surface coatings comprising at least two spraying devices operating in sequential sequence for applying coating agents from the storage vessels (3, 4) to a material arranged on a sample holder (1) and at least one rinsing device (5, 13, 16) for removing unbound molecules from the coated surface.Type: GrantFiled: May 25, 2012Date of Patent: September 12, 2017Assignee: KARLSRUHER INSTITUT FUER TECHNOLOGIEInventors: Christof Woell, Osama Shekhah, Matthias Franzreb, Hasan Arslan, Jonas Wohlgemuth, Roland Fischer
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Publication number: 20140302304Abstract: The present invention relates to a device, the use thereof and a method for producing highly porous, crystalline surface coatings comprising at least two spraying devices operating in sequential sequence for applying coating agents from the storage vessels (3, 4) to a material arranged on a sample holder (1) and at least one rinsing device (5, 13, 16) for removing unbound molecules from the coated surface.Type: ApplicationFiled: May 25, 2012Publication date: October 9, 2014Applicant: KARLSRUHER INSTITUT FUER TECHNOLOGIEInventors: Christof Woell, Osama Shekhah, Matthias Franzreb, Hasan Arslan, Jonas Wohlgemuth, Roland Fischer
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Patent number: 8303822Abstract: The present invention relates to a fixed bed, for example for the isolation and/or purification of components originating from a biological system, which fixed bed comprises magnetic beads and a magnetizable fabric arranged at least in part in the fixed bed, a fluidized bed-fixed bed, which comprises the fixed bed of the invention after application of an alternating magnetic field, and also to a process for the isolation and/or purification of components originating from a biological system.Type: GrantFiled: July 4, 2007Date of Patent: November 6, 2012Assignees: Universität Karlsruhe, Forschungszentrum Karlsruhe GmbHInventors: Rudolf Hausmann, Matthias Franzreb
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Patent number: 8158007Abstract: A method for magnetically assisted extraction of a target substance from an aqueous solution containing a plurality components includes mixing a surfactant and functional magnetic particles having affinity for the target substance into the aqueous solution containing the target substance so as to bind the target substance to the functional magnetic particles and form a particle-containing single-phase aqueous surfactant solution. The particle-containing single-phase aqueous surfactant solution is transitioned to a two-phase state, a first particle- and surfactant-containing disperse phase being formed within a surrounding second phase. The first particle- and surfactant-containing disperse phase and the surrounding second phase are separated using a magnetic field. The first particle- and surfactant-containing disperse phase are separated.Type: GrantFiled: April 23, 2008Date of Patent: April 17, 2012Assignee: Forschungszentrum Karlsruhe GmbHInventors: Matthias Franzreb, Joerg Becker
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Publication number: 20100116747Abstract: A method for magnetically assisted extraction of a target substance from an aqueous solution containing a plurality components includes mixing a surfactant and functional magnetic particles having affinity for the target substance into the aqueous solution containing the target substance so as to bind the target substance to the functional magnetic particles and form a particle-containing single-phase aqueous surfactant solution. The particle-containing single-phase aqueous surfactant solution is transitioned to a two-phase state, a first particle- and surfactant-containing disperse phase being formed within a surrounding second phase. The first particle- and surfactant-containing disperse phase and the surrounding second phase are separated using a magnetic field. The first particle- and surfactant-containing disperse phase are separated.Type: ApplicationFiled: April 23, 2008Publication date: May 13, 2010Applicant: KARLSRUHE INSTITUTE OF TECHNOLOGYInventors: Matthias Franzreb, Joerg Becker
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Patent number: 7691264Abstract: In a semi-permeable membrane system for transferring magnetic particle fractions contained in a first fluid to a second fluid, comprising a membrane through which passages extend and which separates the first fluid from the second fluid being a pressure generation arrangement is provided for generating a reversible pressure differential between the two fluids across the membrane for alternately causing fluid movement in the membrane in opposite directions and a magnetic field generator is provided for alternately generating a magnetic field in the membrane wherein, during the fluid movement in one direction, the magnetic field is switched on to hold the magnetic particles in place in the membrane and, during fluid flow in the opposite flow direction, the magnetic field is switched off to permit the magnetic particles to be moved through the membrane in the other direction.Type: GrantFiled: February 12, 2007Date of Patent: April 6, 2010Assignee: Forschungszentrum Karlsruhe GmbHInventors: Matthias Franzreb, Tilmann Rogge
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Publication number: 20100062509Abstract: The present invention relates to a fixed bed, for example for the isolation and/or purification of components originating from a biological system, which fixed bed comprises magnetic beads and a magnetizable fabric arranged at least in part in the fixed bed, a fluidized bed-fixed bed, which comprises the fixed bed of the invention after application of an alternating magnetic field, and also to a process for the isolation and/or purification of components originating from a biological system.Type: ApplicationFiled: July 4, 2007Publication date: March 11, 2010Applicants: UNIVERSITÄT KARLSRUHE (TH), FORSCHUNGSZENTRUM KARLSRUHE GMBHInventors: Rudolf Hausmann, Matthias Franzreb
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Patent number: 7506765Abstract: In a high-gradient magnetic separator for the selective separation of magnetic particles from a suspension which is conducted through a matrix of plate-like separation structures of a magnetic material which are disposed in a magnetic field and through which the suspension is conducted, alternate plates of the separation structures are movable relative to the other plates which are stationary and are all mounted on a carrier by which they can be moved relative to the stationary plates at least during cleaning of the plates for the removal of magnetic particles collected on the plates.Type: GrantFiled: June 20, 2005Date of Patent: March 24, 2009Assignee: Forschungszentrum Karlsruhe GmbHInventors: Matthias Franzreb, Christian Reichert
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Publication number: 20080035541Abstract: In a semi-permeable membrane system for separating magnetic particle fractions from a mixture contained in a first fluid, comprising a membrane with opposite membrane surfaces between which passages extend and which separates the first fluid from a second fluid each of which is in contact with one of the membrane surfaces, means are provided for generating a reversible pressure differential between the two fluids across the membrane and means for generating and eliminating a magnetic field in the membrane for alternately causing a fluid flow through the membrane in opposite directions wherein, during the fluid flow in one direction, the magnetic field is switched on to hold the magnetic particles in place in the membrane and, during fluid flow in the opposite flow direction, the magnetic field is switched off to permit the magnetic particles to be moved through the membrane in the other direction.Type: ApplicationFiled: February 12, 2007Publication date: February 14, 2008Inventors: Matthias Franzreb, Tilmann Rogge
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Publication number: 20070144976Abstract: In an arrangement for the transport of at least one magnetic particle fraction through a microfluidic system including a structure with micro-channels and means for generating a back and forth flow of fluid in the channels in which the magnetic particle fraction is contained for movement of the magnetic particles through the micro channels, means are provided for generating a magnetic field to be switched on while the fluid flows in one direction for fixing the magnetic particles and to be switched off while the fluid flows in the opposite direction so that the magnetic particles are carried along with the fluid when flowing in that direction.Type: ApplicationFiled: February 26, 2007Publication date: June 28, 2007Inventors: Matthias Franzreb, Tilmann Rogge
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Patent number: 7223345Abstract: High-gradient magnetic filter and method for the separation of weakly magnetisable particles from fluid media (2) in a circuit, embodied as a compact, low-maintenance unit with low repair requirements, comprising a housing (1), for the high gradient magnetic filter, with means for directing the flowing medium (2) in a pipe system with a feed (3) and return (4), a magnetic circuit (5), forming the high-gradient magnet filter in which at least one filter (8) is arranged in a filter chamber (7), formed between the pole faces (6) of the magnetic circuit (5), through which the medium (2) for purification flows, at least one permanent magnet (9), arranged in the magnetic circuit (5), for generation of a magnetic field between the pole faces (6).Type: GrantFiled: April 4, 2002Date of Patent: May 29, 2007Assignee: Steinert Electromagnetbau GmbHInventors: Matthias Franzreb, Harald Leinen, Götz Warlitz
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Patent number: 6991716Abstract: In a device for electro-deionization (EDI) in the demineralization of aqueous solutions, which device includes ion exchange membranes arranged alternately and in spaced relationship so that between the membranes compartments are formed of which at least some are filled with cation and anion resin exchange particle fractions forming a mixed bed ion exchanger, the ion exchange resin particles of one of the two fractions include a magnetic material and a magnetic field generator is provided for generating a field for orienting the magnetic resin particles and arranging them in parallel chains extending between the membranes.Type: GrantFiled: February 5, 2004Date of Patent: January 31, 2006Assignee: Forschungszentrum Karlsruhe GmbHInventor: Matthias Franzreb
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Publication number: 20060016732Abstract: In a high-gradient magnetic separator for the selective separation of magnetic particles from a suspension which is conducted through a matrix of plate-like separation structures of a magnetic material which are disposed in a magnetic field and through which the suspension is conducted, alternate plates of the separation structures are movable relative to the other plates which are stationary and are all mounted on a carrier by which they can be moved relative to the stationary plates at least during cleaning of the plates for the removal of magnetic particles collected on the plates.Type: ApplicationFiled: June 20, 2005Publication date: January 26, 2006Inventors: Matthias Franzreb, Christian Reichert
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Patent number: 6942806Abstract: The invention relates to a method for separating out a substance dispersed or dissolved in a first liquid by using the following steps: a) adding magnetizable particles to the first liquid, so that the substance is adsorbed on the particles; b) immersing a rod consisting of a soft magnetic material into the first liquid; c) magnetizing the rod along its longitudinal axis with an exciter coil, thus causing the particles with the adsorbed substance to be deposited on the rod; d) pulling the rod with thereon deposited particles from the first liquid while the rod is still magnetized; e) immersing the rod into a second liquid; f) turning off the exciter coil and washing off the particles deposited on the rod in the second liquid. Also proposed is a magnet separator for realizing the method.Type: GrantFiled: October 12, 2001Date of Patent: September 13, 2005Assignee: Forschungszentrum Karlsruhe GmbHInventors: Matthias Franzreb, Jonas Wohlgemuth
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Publication number: 20040159612Abstract: High-gradient magnetic filter and method for the separation of weakly magnetizable particles from fluid media (2) in a circuit, embodied as a compact, low-maintenance unit with low repair requirements, comprising a housing (1), for the high gradient magnetic filter, with means for directing the flowing medium (2) in a pipe system with a feed (3) and return (4), a magnetic circuit (5), forming the high-gradient magnet filter in which at least one filter (8) is arranged in a filter chamber (7), formed between the pole faces (6) of the magnetic circuit (5), through which the medium (2) for purification flows, at least one permanent magnet (9), arranged in the magnetic circuit (5), for generation of a magnetic field between the pole faces (6).Type: ApplicationFiled: March 18, 2004Publication date: August 19, 2004Inventors: Matthias Franzreb, Harald Leinen, Gotz Warlitz
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Publication number: 20040154924Abstract: In a device for electro-deionization (EDI) in the demineralization of aqueous solutions, which device includes ion exchange membranes arranged alternately and in spaced relationship so that between the membranes compartments are formed of which at least some are filled with cation and anion resin exchange particle fractions forming a mixed bed ion exchanger, the ion exchange resin particles of one of the two fractions include a magnetic material and a magnetic field generator is provided for generating a field for orienting the magnetic resin particles and arranging them in parallel chains extending between the membranes.Type: ApplicationFiled: February 5, 2004Publication date: August 12, 2004Inventor: Matthias Franzreb
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Publication number: 20040029291Abstract: The invention relates to a method for separating out a substance dispersed or dissolved in a first liquid by using the following steps:Type: ApplicationFiled: September 17, 2003Publication date: February 12, 2004Inventors: Matthias Franzreb, Jonas Wohlgemuth
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Patent number: 6688473Abstract: In a high gradient magnetic separator with a separation zone consisting of a matrix of parallel magnetic wires arranged in parallel planes and channels formed by a non-magnetic material and extending in each plane between adjacent parallel magnetic wires for conducting a fluid including magnetic particles through the matrix, and a magnetizing structure disposed adjacent the matrix for generating a magnetic field with field lines which extend essentially normal to the parallel planes, separating walls are disposed in parts of the channels in the area ahead of the end of the magnetic field generated in the matrix and adjacent the flow exit end of the matrix so as to extend parallel to the planes and normal to the magnetic field lines and form partial flow channels receiving partial fluid flows of magnetic particle-enriched and, respectively, magnetic particle-depleted flow volumes.Type: GrantFiled: January 18, 2002Date of Patent: February 10, 2004Assignee: Forschungszentrum Karlsruhe GmbHInventors: Matthias Franzreb, Wolfgang Höll, Christian Hoffmann