Patents by Inventor Matthias Franzreb

Matthias Franzreb has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11185870
    Abstract: An apparatus for a selective fractionation of ultrafine particles includes at least three separating columns fluidically connected in series by connecting lines. An infeed is arranged to feed into a connecting line which is arranged upstream of each separating column. Each connecting line comprises an inlet for a suspension of ultrafine particles to be separated and an inlet for at least one additional mobile phase. The inlets are alternately operated. A discharge branches off from a connecting line which is arranged downstream of each separating column. Each connecting line comprises an outlet for a first and a second discharge suspension of the ultrafine particles. The outlets are alternately operated. A control means provides a simultaneous switching of the through-flow switching position of the shutoff valves at the inlets and outlets. At least one magnetic field source for a magnetic field is arranged in each separating column.
    Type: Grant
    Filed: February 26, 2018
    Date of Patent: November 30, 2021
    Assignee: KARLSRUHER INSTITUT FUER TECHNOLOGIE
    Inventors: Matthias Franzreb, Moritz Ebeler, Andre Tschoepe
  • Publication number: 20200108401
    Abstract: An apparatus for a selective fractionation of ultrafine particles includes at least three separating columns fluidically connected in series by connecting lines. An infeed is arranged to feed into a connecting line which is arranged upstream of each separating column. Each connecting line comprises an inlet for a suspension of ultrafine particles to be separated and an inlet for at least one additional mobile phase. The inlets are alternately operated. A discharge branches off from a connecting line which is arranged downstream of each separating column. Each connecting line comprises an outlet for a first and a second discharge suspension of the ultrafine particles. The outlets are alternately operated. A control means provides a simultaneous switching of the through-flow switching position of the shutoff valves at the inlets and outlets. At least one magnetic field source for a magnetic field is arranged in each separating column.
    Type: Application
    Filed: February 26, 2018
    Publication date: April 9, 2020
    Applicant: KARLSRUHER INSTITUT FUER TECHNOLOGIE
    Inventors: MATTHIAS FRANZREB, MORITZ EBELER, ANDRE TSCHOEPE
  • Patent number: 9757767
    Abstract: The present invention relates to a device, the use thereof and a method for producing highly porous, crystalline surface coatings comprising at least two spraying devices operating in sequential sequence for applying coating agents from the storage vessels (3, 4) to a material arranged on a sample holder (1) and at least one rinsing device (5, 13, 16) for removing unbound molecules from the coated surface.
    Type: Grant
    Filed: May 25, 2012
    Date of Patent: September 12, 2017
    Assignee: KARLSRUHER INSTITUT FUER TECHNOLOGIE
    Inventors: Christof Woell, Osama Shekhah, Matthias Franzreb, Hasan Arslan, Jonas Wohlgemuth, Roland Fischer
  • Publication number: 20140302304
    Abstract: The present invention relates to a device, the use thereof and a method for producing highly porous, crystalline surface coatings comprising at least two spraying devices operating in sequential sequence for applying coating agents from the storage vessels (3, 4) to a material arranged on a sample holder (1) and at least one rinsing device (5, 13, 16) for removing unbound molecules from the coated surface.
    Type: Application
    Filed: May 25, 2012
    Publication date: October 9, 2014
    Applicant: KARLSRUHER INSTITUT FUER TECHNOLOGIE
    Inventors: Christof Woell, Osama Shekhah, Matthias Franzreb, Hasan Arslan, Jonas Wohlgemuth, Roland Fischer
  • Patent number: 8303822
    Abstract: The present invention relates to a fixed bed, for example for the isolation and/or purification of components originating from a biological system, which fixed bed comprises magnetic beads and a magnetizable fabric arranged at least in part in the fixed bed, a fluidized bed-fixed bed, which comprises the fixed bed of the invention after application of an alternating magnetic field, and also to a process for the isolation and/or purification of components originating from a biological system.
    Type: Grant
    Filed: July 4, 2007
    Date of Patent: November 6, 2012
    Assignees: Universität Karlsruhe, Forschungszentrum Karlsruhe GmbH
    Inventors: Rudolf Hausmann, Matthias Franzreb
  • Patent number: 8158007
    Abstract: A method for magnetically assisted extraction of a target substance from an aqueous solution containing a plurality components includes mixing a surfactant and functional magnetic particles having affinity for the target substance into the aqueous solution containing the target substance so as to bind the target substance to the functional magnetic particles and form a particle-containing single-phase aqueous surfactant solution. The particle-containing single-phase aqueous surfactant solution is transitioned to a two-phase state, a first particle- and surfactant-containing disperse phase being formed within a surrounding second phase. The first particle- and surfactant-containing disperse phase and the surrounding second phase are separated using a magnetic field. The first particle- and surfactant-containing disperse phase are separated.
    Type: Grant
    Filed: April 23, 2008
    Date of Patent: April 17, 2012
    Assignee: Forschungszentrum Karlsruhe GmbH
    Inventors: Matthias Franzreb, Joerg Becker
  • Publication number: 20100116747
    Abstract: A method for magnetically assisted extraction of a target substance from an aqueous solution containing a plurality components includes mixing a surfactant and functional magnetic particles having affinity for the target substance into the aqueous solution containing the target substance so as to bind the target substance to the functional magnetic particles and form a particle-containing single-phase aqueous surfactant solution. The particle-containing single-phase aqueous surfactant solution is transitioned to a two-phase state, a first particle- and surfactant-containing disperse phase being formed within a surrounding second phase. The first particle- and surfactant-containing disperse phase and the surrounding second phase are separated using a magnetic field. The first particle- and surfactant-containing disperse phase are separated.
    Type: Application
    Filed: April 23, 2008
    Publication date: May 13, 2010
    Applicant: KARLSRUHE INSTITUTE OF TECHNOLOGY
    Inventors: Matthias Franzreb, Joerg Becker
  • Patent number: 7691264
    Abstract: In a semi-permeable membrane system for transferring magnetic particle fractions contained in a first fluid to a second fluid, comprising a membrane through which passages extend and which separates the first fluid from the second fluid being a pressure generation arrangement is provided for generating a reversible pressure differential between the two fluids across the membrane for alternately causing fluid movement in the membrane in opposite directions and a magnetic field generator is provided for alternately generating a magnetic field in the membrane wherein, during the fluid movement in one direction, the magnetic field is switched on to hold the magnetic particles in place in the membrane and, during fluid flow in the opposite flow direction, the magnetic field is switched off to permit the magnetic particles to be moved through the membrane in the other direction.
    Type: Grant
    Filed: February 12, 2007
    Date of Patent: April 6, 2010
    Assignee: Forschungszentrum Karlsruhe GmbH
    Inventors: Matthias Franzreb, Tilmann Rogge
  • Publication number: 20100062509
    Abstract: The present invention relates to a fixed bed, for example for the isolation and/or purification of components originating from a biological system, which fixed bed comprises magnetic beads and a magnetizable fabric arranged at least in part in the fixed bed, a fluidized bed-fixed bed, which comprises the fixed bed of the invention after application of an alternating magnetic field, and also to a process for the isolation and/or purification of components originating from a biological system.
    Type: Application
    Filed: July 4, 2007
    Publication date: March 11, 2010
    Applicants: UNIVERSITÄT KARLSRUHE (TH), FORSCHUNGSZENTRUM KARLSRUHE GMBH
    Inventors: Rudolf Hausmann, Matthias Franzreb
  • Patent number: 7506765
    Abstract: In a high-gradient magnetic separator for the selective separation of magnetic particles from a suspension which is conducted through a matrix of plate-like separation structures of a magnetic material which are disposed in a magnetic field and through which the suspension is conducted, alternate plates of the separation structures are movable relative to the other plates which are stationary and are all mounted on a carrier by which they can be moved relative to the stationary plates at least during cleaning of the plates for the removal of magnetic particles collected on the plates.
    Type: Grant
    Filed: June 20, 2005
    Date of Patent: March 24, 2009
    Assignee: Forschungszentrum Karlsruhe GmbH
    Inventors: Matthias Franzreb, Christian Reichert
  • Publication number: 20080035541
    Abstract: In a semi-permeable membrane system for separating magnetic particle fractions from a mixture contained in a first fluid, comprising a membrane with opposite membrane surfaces between which passages extend and which separates the first fluid from a second fluid each of which is in contact with one of the membrane surfaces, means are provided for generating a reversible pressure differential between the two fluids across the membrane and means for generating and eliminating a magnetic field in the membrane for alternately causing a fluid flow through the membrane in opposite directions wherein, during the fluid flow in one direction, the magnetic field is switched on to hold the magnetic particles in place in the membrane and, during fluid flow in the opposite flow direction, the magnetic field is switched off to permit the magnetic particles to be moved through the membrane in the other direction.
    Type: Application
    Filed: February 12, 2007
    Publication date: February 14, 2008
    Inventors: Matthias Franzreb, Tilmann Rogge
  • Publication number: 20070144976
    Abstract: In an arrangement for the transport of at least one magnetic particle fraction through a microfluidic system including a structure with micro-channels and means for generating a back and forth flow of fluid in the channels in which the magnetic particle fraction is contained for movement of the magnetic particles through the micro channels, means are provided for generating a magnetic field to be switched on while the fluid flows in one direction for fixing the magnetic particles and to be switched off while the fluid flows in the opposite direction so that the magnetic particles are carried along with the fluid when flowing in that direction.
    Type: Application
    Filed: February 26, 2007
    Publication date: June 28, 2007
    Inventors: Matthias Franzreb, Tilmann Rogge
  • Patent number: 7223345
    Abstract: High-gradient magnetic filter and method for the separation of weakly magnetisable particles from fluid media (2) in a circuit, embodied as a compact, low-maintenance unit with low repair requirements, comprising a housing (1), for the high gradient magnetic filter, with means for directing the flowing medium (2) in a pipe system with a feed (3) and return (4), a magnetic circuit (5), forming the high-gradient magnet filter in which at least one filter (8) is arranged in a filter chamber (7), formed between the pole faces (6) of the magnetic circuit (5), through which the medium (2) for purification flows, at least one permanent magnet (9), arranged in the magnetic circuit (5), for generation of a magnetic field between the pole faces (6).
    Type: Grant
    Filed: April 4, 2002
    Date of Patent: May 29, 2007
    Assignee: Steinert Electromagnetbau GmbH
    Inventors: Matthias Franzreb, Harald Leinen, Götz Warlitz
  • Patent number: 6991716
    Abstract: In a device for electro-deionization (EDI) in the demineralization of aqueous solutions, which device includes ion exchange membranes arranged alternately and in spaced relationship so that between the membranes compartments are formed of which at least some are filled with cation and anion resin exchange particle fractions forming a mixed bed ion exchanger, the ion exchange resin particles of one of the two fractions include a magnetic material and a magnetic field generator is provided for generating a field for orienting the magnetic resin particles and arranging them in parallel chains extending between the membranes.
    Type: Grant
    Filed: February 5, 2004
    Date of Patent: January 31, 2006
    Assignee: Forschungszentrum Karlsruhe GmbH
    Inventor: Matthias Franzreb
  • Publication number: 20060016732
    Abstract: In a high-gradient magnetic separator for the selective separation of magnetic particles from a suspension which is conducted through a matrix of plate-like separation structures of a magnetic material which are disposed in a magnetic field and through which the suspension is conducted, alternate plates of the separation structures are movable relative to the other plates which are stationary and are all mounted on a carrier by which they can be moved relative to the stationary plates at least during cleaning of the plates for the removal of magnetic particles collected on the plates.
    Type: Application
    Filed: June 20, 2005
    Publication date: January 26, 2006
    Inventors: Matthias Franzreb, Christian Reichert
  • Patent number: 6942806
    Abstract: The invention relates to a method for separating out a substance dispersed or dissolved in a first liquid by using the following steps: a) adding magnetizable particles to the first liquid, so that the substance is adsorbed on the particles; b) immersing a rod consisting of a soft magnetic material into the first liquid; c) magnetizing the rod along its longitudinal axis with an exciter coil, thus causing the particles with the adsorbed substance to be deposited on the rod; d) pulling the rod with thereon deposited particles from the first liquid while the rod is still magnetized; e) immersing the rod into a second liquid; f) turning off the exciter coil and washing off the particles deposited on the rod in the second liquid. Also proposed is a magnet separator for realizing the method.
    Type: Grant
    Filed: October 12, 2001
    Date of Patent: September 13, 2005
    Assignee: Forschungszentrum Karlsruhe GmbH
    Inventors: Matthias Franzreb, Jonas Wohlgemuth
  • Publication number: 20040159612
    Abstract: High-gradient magnetic filter and method for the separation of weakly magnetizable particles from fluid media (2) in a circuit, embodied as a compact, low-maintenance unit with low repair requirements, comprising a housing (1), for the high gradient magnetic filter, with means for directing the flowing medium (2) in a pipe system with a feed (3) and return (4), a magnetic circuit (5), forming the high-gradient magnet filter in which at least one filter (8) is arranged in a filter chamber (7), formed between the pole faces (6) of the magnetic circuit (5), through which the medium (2) for purification flows, at least one permanent magnet (9), arranged in the magnetic circuit (5), for generation of a magnetic field between the pole faces (6).
    Type: Application
    Filed: March 18, 2004
    Publication date: August 19, 2004
    Inventors: Matthias Franzreb, Harald Leinen, Gotz Warlitz
  • Publication number: 20040154924
    Abstract: In a device for electro-deionization (EDI) in the demineralization of aqueous solutions, which device includes ion exchange membranes arranged alternately and in spaced relationship so that between the membranes compartments are formed of which at least some are filled with cation and anion resin exchange particle fractions forming a mixed bed ion exchanger, the ion exchange resin particles of one of the two fractions include a magnetic material and a magnetic field generator is provided for generating a field for orienting the magnetic resin particles and arranging them in parallel chains extending between the membranes.
    Type: Application
    Filed: February 5, 2004
    Publication date: August 12, 2004
    Inventor: Matthias Franzreb
  • Publication number: 20040029291
    Abstract: The invention relates to a method for separating out a substance dispersed or dissolved in a first liquid by using the following steps:
    Type: Application
    Filed: September 17, 2003
    Publication date: February 12, 2004
    Inventors: Matthias Franzreb, Jonas Wohlgemuth
  • Patent number: 6688473
    Abstract: In a high gradient magnetic separator with a separation zone consisting of a matrix of parallel magnetic wires arranged in parallel planes and channels formed by a non-magnetic material and extending in each plane between adjacent parallel magnetic wires for conducting a fluid including magnetic particles through the matrix, and a magnetizing structure disposed adjacent the matrix for generating a magnetic field with field lines which extend essentially normal to the parallel planes, separating walls are disposed in parts of the channels in the area ahead of the end of the magnetic field generated in the matrix and adjacent the flow exit end of the matrix so as to extend parallel to the planes and normal to the magnetic field lines and form partial flow channels receiving partial fluid flows of magnetic particle-enriched and, respectively, magnetic particle-depleted flow volumes.
    Type: Grant
    Filed: January 18, 2002
    Date of Patent: February 10, 2004
    Assignee: Forschungszentrum Karlsruhe GmbH
    Inventors: Matthias Franzreb, Wolfgang Höll, Christian Hoffmann