Patents by Inventor Matthias Friebe
Matthias Friebe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12230387Abstract: A computer apparatus and computer-implemented process for generating a batch record (BR) from a master batch record (MBR) during manufacture of a batch of pharmaceutical product. In the control software, a graphical analysis interface is provided for processing graphs of spectroscopic or chromatographic analysis. A group of fields in the MBR is assigned to the analysis. The operator wears an augmented reality headset and uses this to capture an image of a graph from an instrument display. The graph image is then processed to extract the graph and its metadata, and then further processed to find peaks and assign attribute labels to the peaks, and thus populate the analysis fields. Overlay images are then transmitted to AR headset to present to the operator the populated analysis fields. The operator then accepts or rejects the populated analysis fields by issuing user interface commands.Type: GrantFiled: December 12, 2023Date of Patent: February 18, 2025Assignee: Augmenticon AGInventor: Matthias Friebe
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Publication number: 20240161917Abstract: A computer apparatus and computer-implemented process for generating a batch record (BR) from a master batch record (MBR) during manufacture of a batch of pharmaceutical product. In the control software, a graphical analysis interface is provided for processing graphs of spectroscopic or chromatographic analysis. A group of fields in the MBR is assigned to the analysis. The operator wears an augmented reality headset and uses this to capture an image of a graph from an instrument display. The graph image is then processed to extract the graph and its metadata, and then further processed to find peaks and assign attribute labels to the peaks, and thus populate the analysis fields. Overlay images are then transmitted to AR headset to present to the operator the populated analysis fields. The operator then accepts or rejects the populated analysis fields by issuing user interface commands.Type: ApplicationFiled: December 12, 2023Publication date: May 16, 2024Applicant: Augmenticon GmbHInventor: Matthias Friebe
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Publication number: 20240136057Abstract: A computer apparatus and computer-implemented process for generating a batch record (BR) from a master batch record (MBR) during manufacture of a batch of pharmaceutical product. In the control software, a graphical analysis interface is provided for processing graphs of spectroscopic or chromatographic analysis. A group of fields in the MBR is assigned to the analysis. The operator wears an augmented reality headset and uses this to capture an image of a graph from an instrument display. The graph image is then processed to extract the graph and its metadata, and then further processed to find peaks and assign attribute labels to the peaks, and thus populate the analysis fields. Overlay images are then transmitted to AR headset to present to the operator the populated analysis fields. The operator then accepts or rejects the populated analysis fields by issuing user interface commands.Type: ApplicationFiled: December 12, 2023Publication date: April 25, 2024Applicant: Augmenticon GmbHInventor: Matthias Friebe
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Publication number: 20240120079Abstract: A computer apparatus and computer-implemented process for generating a batch record (BR) from a master batch record (MBR) during manufacture of a batch of pharmaceutical product. In the control software, a graphical analysis interface is provided for processing graphs of spectroscopic or chromatographic analysis. A group of fields in the MBR is assigned to the analysis. The operator wears an augmented reality headset and uses this to capture an image of a graph from an instrument display. The graph image is then processed to extract the graph and its metadata, and then further processed to find peaks and assign attribute labels to the peaks, and thus populate the analysis fields. Overlay images are then transmitted to AR headset to present to the operator the populated analysis fields. The operator then accepts or rejects the populated analysis fields by issuing user interface commands.Type: ApplicationFiled: December 12, 2023Publication date: April 11, 2024Applicant: Augmenticon GmbHInventor: Matthias Friebe
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Patent number: 11894130Abstract: A computer apparatus and computer-implemented process for generating a batch record (BR) from a master batch record (MBR) during manufacture of a batch of pharmaceutical product. In the control software, a graphical analysis interface is provided for processing graphs of spectroscopic or chromatographic analysis. A group of fields in the MBR is assigned to the analysis. The operator wears an augmented reality headset and uses this to capture an image of a graph from an instrument display. The graph image is then processed to extract the graph and its metadata, and then further processed to find peaks and assign attribute labels to the peaks, and thus populate the analysis fields. Overlay images are then transmitted to AR headset to present to the operator the populated analysis fields. The operator then accepts or rejects the populated analysis fields by issuing user interface commands.Type: GrantFiled: December 23, 2020Date of Patent: February 6, 2024Assignee: Augmenticon GmbHInventor: Matthias Friebe
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Publication number: 20210202079Abstract: A computer apparatus and computer-implemented process for generating a batch record (BR) from a master batch record (MBR) during manufacture of a batch of pharmaceutical product. In the control software, a graphical analysis interface is provided for processing graphs of spectroscopic or chromatographic analysis. A group of fields in the MBR is assigned to the analysis. The operator wears an augmented reality headset and uses this to capture an image of a graph from an instrument display. The graph image is then processed to extract the graph and its metadata, and then further processed to find peaks and assign attribute labels to the peaks, and thus populate the analysis fields. Overlay images are then transmitted to AR headset to present to the operator the populated analysis fields. The operator then accepts or rejects the populated analysis fields by issuing user interface commands.Type: ApplicationFiled: December 23, 2020Publication date: July 1, 2021Applicant: Augmenticon GmbHInventor: Matthias Friebe
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Publication number: 20210200193Abstract: A computer-implemented process and computer apparatus for generating a quality control, QC, record to document line clearance of a pharmaceutical production line. The computer apparatus comprises a process data structure defining a sequence of operator actions and a line clearance protocol comprising content items and associated fields; and a mapping data structure that links operator actions to content items and fields. The operator populates the fields while progressing through the operator actions supported by an augmented reality, AR, headset which receives overlay image data of the content items and fields and transmits user input populating the fields. An automated QC check of the line clearance is performed based on an automated analysis of the field entries and outputs a QC check outcome. The QC record and QC check outcome are then transmitted to a workstation for review by a supervisor who makes a line clearance decision on that basis.Type: ApplicationFiled: December 23, 2020Publication date: July 1, 2021Applicant: Augmenticon GmbHInventor: Matthias Friebe
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Patent number: 9592308Abstract: This invention relates to methods, which provide access to [F-18]fluoropegylated (aryl/heteroaryl vinyl)-phenyl methyl amine derivatives.Type: GrantFiled: March 7, 2016Date of Patent: March 14, 2017Assignee: PIRAMAL IMAGING SAInventors: Mathias Berndt, Matthias Friebe, Fabrice Samson, Rainer Braun, Gunnar Garke, Marianne Patt, Andreas Schildan, Christoph Smuda
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Patent number: 9375497Abstract: The compounds and the synthesis of [F-18]-labeled L-glutamic acid, [F-18]-labeled L-glutamate, their derivatives as set forth in formula (I) and their uses are described.Type: GrantFiled: January 13, 2014Date of Patent: June 28, 2016Assignee: PIRAMAL IMAGING SAInventors: Ludger Dinkelborg, Matthias Friebe, Nikolaevna Raisa Krasikowa, Yuri Belokon, Fedorovna Olga Kuznetsova, Keith Graham, Lutz Lehmann, Mathias Berndt
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Patent number: 9308282Abstract: What is described are the compounds and the synthesis of [F-18]-labelled L-glutamic acid, [F-18]-labelled L-glutamate, their derivatives of the formula (I) and their use.Type: GrantFiled: February 5, 2014Date of Patent: April 12, 2016Assignee: PIRAMAL IMAGING SAInventors: Matthias Friebe, Heribert Schmitt-Willich, Matthias Berndt, Ludger Dinkelborg, Norman Koglin, Keith Graham
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Patent number: 9017645Abstract: This invention relates to homoglutamic acid derivatives suitable for labeling or already labeled with 18F or 19F, methods of preparing such compounds, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such compounds, compositions or kits for diagnostic imaging.Type: GrantFiled: November 8, 2010Date of Patent: April 28, 2015Assignee: Piramal Imaging SAInventors: Heribert Schmitt-Willich, Niels Böhnke, Norman Koglin, Andre Müller, Mathias Berndt, Matthias Friebe, Lutz Lehmann
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Patent number: 9000037Abstract: This invention relates to novel precursors suitable for 18F radiolabeling of glutamate derivatives, methods for preparing such compounds and its intermediates, compositions comprising such compounds, kits comprising such compounds or compositions and methods for 18F radiolabeling of glutamate derivatives wherein the obtained 18F radiolabeled glutamate derivatives are suitable for diagnostic imaging by Positron Emission Tomography (PET) of proliferative diseases e.g. tumor in mammals.Type: GrantFiled: April 30, 2012Date of Patent: April 7, 2015Assignee: Piramal Imaging SAInventors: Christina Hultsch, Michael Harre, Filip Novak, Mathias Berndt, Matthias Friebe, Heribert Schmitt-Willich, Dae Yoon Chi, Byoung Se Lee, Sang Don Park
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Patent number: 8981156Abstract: This invention relates to methods, which provide access to [F-18]fluoropegylated (aryl/heteroaryl vinyl)-phenyl methyl amine derivatives.Type: GrantFiled: May 30, 2011Date of Patent: March 17, 2015Assignee: Piramal Imaging SAInventors: Mathias Berndt, Matthias Friebe, Christina Hultsch, Fabrice Samson, Marianne Patt, Andreas Schildan, Christoph Smuda
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Publication number: 20140243532Abstract: This invention relates to novel precursors suitable for 18F radiolabeling of glutamate derivatives, methods for preparing such compounds and its intermediates, compositions comprising such compounds, kits comprising such compounds or compositions and methods for 18F radiolabeling of glutamate derivatives wherein the obtained 18F radiolabeled glutamate derivatives are suitable for diagnostic imaging by Positron Emission Tomography (PET) of proliferative diseases e.g. tumor in mammals.Type: ApplicationFiled: April 30, 2012Publication date: August 28, 2014Applicant: PIRAMAL IMAGING SAInventors: Christina Hultsch, Michael Harre, Filip Novak, Mathias Berndt, Matthias Friebe, Heribert Schmitt-Willich, Dae Yoon Chi, Byoung Se Lee, Sang Don Park
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Publication number: 20130217920Abstract: This invention relates to methods, which provide access to [F-18]fluoropegylated (aryl/heteraryl vinyl)-phenyl methyl amine derivatives.Type: ApplicationFiled: May 30, 2011Publication date: August 22, 2013Applicant: PIRAMAL IMAGING SAInventors: Mathias Berndt, Matthias Friebe, Christina Hultsch, Fabrice Samson, Seung Jun Oh, Christoph Smuda
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Publication number: 20130209363Abstract: This invention relates to methods, which provide access to [F-18]fluoropegylated (aryl/heteroaryl vinyl)-phenyl methyl amine derivatives.Type: ApplicationFiled: May 30, 2011Publication date: August 15, 2013Applicant: PIRAMAL IMAGING SAInventors: Mathias Berndt, Matthias Friebe, Fabrice Samson, Rainer Braun, Gunnar Garke, Marianne PATT, Andreas Schildan, Christoph Smuda
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Patent number: 8491906Abstract: The present invention relates to selectively targeting tumoral vasculature in vivo using a human recombinant scFv, L19, to the angiogenesis marker ED-B domain of fibronectin. In preferred embodiments, a complete human IgG1 is employed having the variable regions of L19. In other preferred embodiments is employed a mini-immunoglobulin generated by fusing the scFv L19 to the constant CH4 domain of a secretory IgE isoform that naturally contains a cysteine in its COOH terminal and which forms a covalently linked dimer. Different in vivo behavior of the antibody formats is exploitable for different diagnostic and/or therapeutic purposes, depending on clinical needs and disease. The antibody molecules may be labelled as described.Type: GrantFiled: March 11, 2003Date of Patent: July 23, 2013Assignees: Philogen S.p.A., Bayer Schering Pharma AGInventors: Laura Borsi, Barbara Carnemolla, Enrica Balza, Patrizia Castellani, Luciano Zardi, Matthias Friebe, Christoph-Stephan Hilger
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Publication number: 20130172620Abstract: This invention relates to methods, which provide access to [F-18]fluoropegylated (aryl/heteroaryl vinyl)-phenyl methyl amine derivatives.Type: ApplicationFiled: May 30, 2011Publication date: July 4, 2013Applicant: PIRAMAL IMAGING SAInventors: Mathias Berndt, Matthias Friebe, Christina Hultsch, Fabrice Samson, Marianne Patt, Andreas Schildan, Christoph Smuda
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Publication number: 20130149243Abstract: This invention relates to methods, which provide access to F-18 labeled glutamic acid derivatives.Type: ApplicationFiled: November 6, 2010Publication date: June 13, 2013Applicant: BAYER INTELLECTUAL PROPERTY GMBHInventors: Mathias Berndt, Heribert Schmitt-Willich, Matthias Friebe, Keith Graham, Thomas Brumby, Christina Hultsch, Hans-Jürgen Wester, Franziska Wagner
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Publication number: 20130071327Abstract: This invention relates to homoglutamic acid derivatives suitable for labeling or already labeled with 18F or 19F, methods of preparing such compounds, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such compounds, compositions or kits for diagnostic imaging.Type: ApplicationFiled: November 8, 2010Publication date: March 21, 2013Applicant: PIRAMAL IMAGING SAInventors: Heribert Schmitt-Willich, Niels Böhnke, Norman Koglin, Andre Müller, Mathias Berndt, Matthias Friebe, Lutz Lehmann