Abstract: A novel RMP homologue is provided, as well as nucleic acids encoding the protein and antisense nucleic acids, Methods of diagnosing conditions dependent on RMP are provided as well as screening methods for identify agents active against conditions dependent on RMP, such as conditions dependent on amino acid regulation, cancer, neurodegeneration, muscle degeneration, immune disorders, and AIDS.

Abstract: Methods of identifying anti-cancer agents are provided based on ligand binding or enzymatic activity of TIP49 family members. The assays may include the measurement of ATPase and/or helicase activity. Also provided are anti-cancer agents identified by the screening methods of the invention, as well as the use of the agent for the prophylaxis or treatment of cancer. A complex of a TIP49 family member with various proteins that regulate transcription is also provided.

Abstract: Protein complexes containing a SKP2 binding protein (STAP1) are provided useful in identifying anti-cancer agents. Also provided are agents identified using the methods for use as therapeutics.