Patents by Inventor Matthias GRIMMLER

Matthias GRIMMLER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210382044
    Abstract: A method for measuring the presence of calprotectin (S100A8/A) heterodimer in a biological sample using a particle-enhanced turbidimetric immunoassay (PETIA) based on monoclonal antibodies. The method can be adapted on automated standard analyzers and provides a reliable clinical measurement of calprotectin in faecal samples and extracts. The method is comparable to commerical two-site sandwich ELISA. The disclosed method counters spontaneous agglutination caused by calcium ions and low-molecular weight calcium-binding S100 proteins as observed with conventional PETIAs. The method can be used for measuring the presence of human calprotectin in stool, urine, serum, plasma, synovial liquid and other body liquids. Metrological traceability and high commutability with conventional immunoassays (ELISA) has been shown despite of different measurement principles used.
    Type: Application
    Filed: May 9, 2018
    Publication date: December 9, 2021
    Applicants: Immundiagnostik AG, Diasys Diagnostic Systems GmbH
    Inventors: Franz-Paul Armbruster, Matthias Grimmler, Pia Schu, Tobias Becker, Felix Walzer
  • Publication number: 20200362386
    Abstract: A method for quantitatively determining the amount of acetaminophen in a sample with greater precision, greater sensitivity and fewer interactions and fewer spectral and chemical interferences with other compounds contained in the sample. The method includes acetaminophen being hydrolyzed and the resulting p-minophenol being reacted with a compound of general formula (III) in the presence of an oxidant, wherein R1 and R2, independently of one another, are selected from H, —CH3, and —OCH3, R3 is —C2H5 and R4 is a C1-4 alkyl moiety with a terminal sulfonate group, with the proviso that at least one of R1 and R2 is —OCH3 and/or R4 additionally has at least one OH substituent, and then the amount of the compound of general formula (IV) in the reaction mixture being photometrically determined.
    Type: Application
    Filed: January 8, 2019
    Publication date: November 19, 2020
    Applicant: DiaSys Diagnostic Systems GmbH
    Inventors: Matthias GRIMMLER, Detlef THÖNGES, Pia SCHU, Carolin MENZENBACH, Laura KRECKEL
  • Patent number: 10202632
    Abstract: A method for determining the amount of glycated hemoglobin (HbA1c), in which—if required—the erythrocytes in a sample are hemolyzed, the haemoglobin that is then released—if required—is contacted with a proteolytic agent and the glycated hemoglobin degradation products obtained in this way or otherwise are quantified is disclosed. In order to provide such a process and reagents employable therein that has/have the property of sufficient stability of the chemical compounds that are essential to the reaction, the provision of the requisite proteolytic agent in the form of an inactivated protease is proposed, which is then only reactivated in situ.
    Type: Grant
    Filed: March 31, 2015
    Date of Patent: February 12, 2019
    Assignee: DiaSys Diagnostic Systems GmbH
    Inventors: Günther Gorka, Yoshifumi Watazu, Erwin Metzmann, Alexandra Lein, Holger Müller, Matthias Grimmler
  • Patent number: 10093959
    Abstract: A method for determining the amount of glycated haemoglobin (HbA1c), in which—if required—the erythrocytes in a sample are haemolysed, the haemoglobin that is then released—if required—is contacted with a proteolytic agent and the glycated haemoglobin degradation products obtained in this way or otherwise are quantified is disclosed. In order to provide such a process and reagents employable therein that has/have the property of sufficient stability of the chemical compounds that are essential to the reaction, for the stabilization of the haemoglobin which is unfolded at a very low pH in the range from 1 to 3, at least one suitable stabilizer is present in the haemolysis solution.
    Type: Grant
    Filed: May 6, 2015
    Date of Patent: October 9, 2018
    Assignee: DiaSys Diagnostic Systems GmbH
    Inventors: Günther Gorka, Yoshifumi Watazu, Erwin Metzmann, Alexandra Lein, Holger Müller, Matthias Grimmler
  • Publication number: 20170191112
    Abstract: A method for determining the amount of glycated haemoglobin (HbA1c), in which—if required—the erythrocytes in a sample are haemolysed, the haemoglobin that is then released—if required—is contacted with a proteolytic agent and the glycated haemoglobin degradation products obtained in this way or otherwise are quantified is disclosed. In order to provide such a process and reagents employable therein that has/have the property of sufficient stability of the chemical compounds that are essential to the reaction, the provision of the requisite proteolytic agent in the form of an inactivated protease is proposed, which is then only reactivated in situ.
    Type: Application
    Filed: March 31, 2015
    Publication date: July 6, 2017
    Inventors: Günther GORKA, Yoshifumi WATAZU, Erwin METZMANN, Alexandra LEIN, Holger MÜLLER, Matthias GRIMMLER
  • Publication number: 20170058318
    Abstract: A method for determining the amount of glycated haemoglobin (HbA1c), in which—if required—the erythrocytes in a sample are haemolysed, the haemoglobin that is then released—if required—is contacted with a proteolytic agent and the glycated haemoglobin degradation products obtained in this way or otherwise are quantified is disclosed. In order to provide such a process and reagents employable therein that has/have the property of sufficient stability of the chemical compounds that are essential to the reaction, for the stabilization of the haemoglobin which is unfolded at a very low pH in the range from 1 to 3, at least one suitable stabilizer is present in the haemolysis solution.
    Type: Application
    Filed: May 6, 2015
    Publication date: March 2, 2017
    Inventors: Günther GORKA, Yoshifumi WATAZU, Erwin METZMANN, Alexandra LEIN, Holger MÜLLER, Matthias GRIMMLER