Abstract: The present invention provides a method of detecting senescent cells or diagnosing cellular senescence in a subject wherein the level of one or more selected miRNAs is quantified in a sample from said subject.

Abstract: The present invention provides a method of detecting senescent cells or diagnosing cellular senescence in a subject wherein the level of one or more selected miRNAs is quantified in a sample from said subject.

Abstract: The invention relates to an in vitro method of determining a subjects risk of liver dysfunction, specifically after partial liver resection, said method comprising the steps of providing a sample from said subject, determining in said sample the expression level of at least one miRNA, selected from the group consisting of miR-151a, miR-192 and miR-122, and comparing these expression level(s) with at least one reference expression level, or identifying the ratios of the expression levels of miR-15 la to miR-192 and/or of miR-122 to miR-151a and comparing said expression level ratios with reference expression level ratios, and classifying the sample from the outcome of the comparison into one of at least two classes, wherein each class is one of the at least two categories “high-risk” and “low-risk”.

Abstract: The invention relates to an in vitro method of determining a subjects risk of liver dysfunction, specifically after partial liver resection, said method comprising the steps of providing a sample from said subject, determining in said sample the expression level of at least one miRNA, selected from the group consisting of miR-15 la, miR-192 and miR-122, and comparing these expression level(s) with at least one reference expression level, or identifying the ratios of the expression levels of miR-15 la to miR-192 and/or of miR-122 to miR-151a and comparing said expression level ratios with reference expression level ratios, and classifying the sample from the outcome of the comparison into one of at least two classes, wherein each class is one of the at least two categories “high-risk” and “low-risk”.

Abstract: The present invention relates to the therapy, prophylaxis and diagnosis of disorders that are associated with aberrant bone mineral density, in particular osteoporosis; wherein the level of selected microRNAs in samples of patients are detected and wherein an increase or decrease of said level compared to the level of healthy individuals is indicative of the disorder.

Abstract: The present invention relates to the therapy, prophylaxis and diagnosis of disorders that are associated with aberrant bone mineral density, in particular osteoporosis; wherein the level of selected microRNAs in samples of patients are detected and wherein an increase or decrease of said level compared to the level of healthy indivduals is indicative of the disorder.

Abstract: The present invention relates to the therapy, prophylaxis and diagnosis of disorders that are associated with aberrant bone mineral density, in particular osteoporosis; wherein the level of selected micro RNAs in samples of patients are detected and wherein an increase or decrease of said level compared to the level of healthy individuals is indicative of the disorder.

Abstract: The present invention relates to the therapy, prophylaxis and diagnosis of disorders that are associated with aberrant bone mineral density, in particular osteoporosis; wherein the level of selected micro RNAs in samples of patients are detected and wherein an increase or decrease of said level compared to the level of healthy individuals is indicative of the disorder.

Abstract: Device and method are described for operating a vehicle using a vehicle controller to individually adjust braking forces of the wheels of at least one axle of the vehicle and using a yawing moment compensator to at least partially compensate for a yawing moment of the vehicle resulting from different braking forces of individual wheels of at least one axle by intervening in a steering of the vehicle, the action of the yawing moment compensator on the steering not being performed or only to a lesser degree while the vehicle controller is adjusting braking forces.

Abstract: Device and method for operating a vehicle using a vehicle controller to individually adjust braking forces of the wheels of at least one axle of the vehicle and using a yawing moment compensator to at least partially compensate for a yawing moment of the vehicle resulting from different braking forces of individual wheels of at least one axle by intervening in a steering of the vehicle, the action of the yawing moment compensator on the steering not being performed or only to a lesser degree while the vehicle controller is adjusting braking forces.

Abstract: The precharging device is part of a hydraulic brake system of a vehicle and serves to impose brake fluid under pressure selectively on a brake assembly, by means of a charging unit. To activate the imposition of brake fluid, the charging unit is operatively connected to a fuel supply system. The charging unit is preferably embodied as a piston unit.

Abstract: A steering system for a motor vehicle having at least one steerable wheel, an actuator and a superposing gear assembly. The steering movement, which is initiated by the driver of the vehicle, and the movement, which is initiated by the actuator, are superposed by the superposing gear assembly for generating a steering movement of the steerable wheel within pregiven steering stops. The essence of the invention is that the movement, which is initiated by the actuator, is at least reduced before reaching the steering stop. According to the invention, one arrives at a superposed steering with which the steering stops are considered so as to provide increased safety and increased comfort.

Abstract: The precharging device is part of a hydraulic brake system of a vehicle and serves to impose brake fluid under pressure selectively on a brake assembly, by means of a charging unit. To activate the imposition of brake fluid, the charging unit is operatively connected to a fuel supply system. The charging unit is preferably embodied as a piston unit.

Abstract: A method for actuating a “steer-by-wire” steering drive mechanism by means of at least two triggerable control motors and gear units downstream of them, by which a gear element, connected to the wheels, can be driven simultaneously, is characterized in that the two control motors can be triggered independently of one another in such a way that by them both, drive forces in both the same direction and opposite directions and of equal or different amounts oriented in both the same and in opposite directions can be generated simultaneously.

Abstract: The invention relates to a steering system for a motor vehicle having at least one steerable wheel, an actuator and a superposing gear assembly. The steering movement, which is initiated by the driver of the vehicle, and the movement, which is initiated by the actuator, are superposed by the superposing gear assembly for generating a steering movement of the steerable wheel within pregiven steering stops. The essence of the invention is that the movement, which is initiated by the actuator, is at least reduced before reaching the steering stop. According to the invention, one arrives at a superposed steering with which the steering stops are considered so as to provide increased safety and increased comfort.

Abstract: A steering system for a motor vehicle with at least one steerable wheel, an actuator, and an auxiliary drive. The steering motion initiated by the driver of the vehicle and the motion initiated by the actuator are superimposed by the auxiliary drive to generate the steering motion of the steerable wheel. At least two steering components are computed and a control signal is generated to control the actuator by superimposing the computed steering components. The steering components are computed in parallel and independently of one another so that several functions are beneficially combined to control running behavior. This provides an improvement of running dynamics by means of steering interventions.

Abstract: A steering system for a motor vehicle with a steering drive train having at least one steerable wheel, one actuator and one auxiliary drive. The steering wheel is operable by the driver of the vehicle as well as by mechanically configured offset devices. The offset devices have rotating input and output shafts and a predetermined offset angle between the input shaft and the output shaft. The auxiliary drive superimposes the steering motion initiated by the steering wheel and the motion initiated by the actuator to generate the steering motion of the steerable wheel. A control signal dependent on the angular offset and the rotational motion of the input shaft is computed. The actuator is then controlled dependent on at least the generated control signal to initiate the actuator initiated motion. Any structurally unavoidable nonuniformity of rotational motion is compensated for by the superimposition of an appropriate added angle.

Abstract: A steering system for a motor vehicle with at least one steerable wheel, one actuator, and one auxiliary drive. The auxiliary drive superimposes the steering motion initiated by the driver of the vehicle and the motion initiated by the actuator to generate the steering motion of the steerable wheel. A yaw parameter representing the yawing motion of the vehicle is detected, and a control signal is calculated when a predetermined running condition prevails, dependent at least on the detected yaw parameter. The actuator is then controlled by the generated control signal to initiate the motion. A braking parameter representing the braking condition of the vehicle is also detected, and the existence of the running condition is determined dependent on this detected braking parameter whereby yaw behavior is improved. Active steering intervention is switched in only when an external disturbance of vehicle motion is detected.

Abstract: A power steering system for a motor vehicle, comprising a steering wheel actuated by the driver of the vehicle, at least one steered wheel, an actuator motor that is activated to assist the steering movement initiated by the driver and a locking device for locking the steering wheel in at least one predetermined position. The steering wheel is moved to the predetermined position by activation of the actuator motor upon detection of a predetermined preset operating condition. Using the actuator motor to move the steering wheel to the predetermined position frees the driver from having to manually turn the steering wheel to the locking position upon shutdown of the vehicle. This has the advantage of increasing the comfort of such a steering system since the driver is freed from having to turn the steering wheel after shutdown of the vehicle and of increasing protection against theft since the driver does not have to remember to engage the steering lock upon shutdown of the vehicle.

Abstract: A steering system for a motor vehicle, comprising at least one steered axle, an actuator, an actuator motor and a steering mechanism. The actuator and the steering mechanism, respectively, each have a mechanical gear ratio. The steered axle, the actuator motor, the actuator and the steering mechanism are operatively connected with one another. Steering movements initiated by the driver and movements initiated by the actuator motor are superimposed by the actuator. The superimposed movement is passed to the steering gear, which relays this movement as steering angle to the wheels of the steered axle. The steering gear mechanical gear ratio is configured to be variable which enables selectively adjustable relationships between the steering wheel movements and the steering angles of the steered wheels and avoids the loss of good steering feel for the driver.