Patents by Inventor Matthias Hebrok

Matthias Hebrok has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Preservation of pancreatic islet grafts in the extrahepatic space
    Patent number: 11951136
    Abstract: Provided herein, inter alia, are methods and compositions for treating diabetes mellitus comprising co-transplantation of an insulin-producing cell and a cell derived from a parathyroid gland (PTG), a CD34+ cell derived from a parathyroid gland, a CD34+ cell derived from a stem cell, or other progenitor cell-derived CD34+ cell.
    Type: Grant
    Filed: December 12, 2018
    Date of Patent: April 9, 2024
    Assignees: The Regents of the University of California, The United States Government as Represented by the Department of Veterans Affairs
    Inventors: Casey Ward, Qizhi Tang, Peter Stock, Gaetano Faleo, Gopika Nair, Matthias Hebrok, Wenhan Chang, Thuy Vo, Jeffrey A. Bluestone, Eleonora De Klerk
  • Methods for Generating Thymic Cells in Vitro
    Publication number: 20230159887
    Abstract: The present description provides improved methods for generating thymic epithelial progenitor (TEP) cells from pluripotent stem (PS) cells in vitro. Also provided are isolated invitro cell populations, compositions, and systems comprising TEP cells produced in vitro. Compositions and systems of cell populations of thymic epithelial cells and subpopulations thereof, as well as cells formed during different stages of differentiation of PS cells into thymic epithelial cells and subpopulations thereof are provided.
    Type: Application
    Filed: April 27, 2021
    Publication date: May 25, 2023
    Inventors: Audrey Parent, Matthias Hebrok, Mark Stuart Anderson
  • Methods and compositions for producing pancreatic beta cells
    Patent number: 11332716
    Abstract: Compositions and methods of producing mammalian cell populations that include a high proportion of pancreatic beta cells are described herein. Such cell populations are useful for treatment of diabetes. Also provided are materials and methods for the direct differentiation of stem cells, such as embryonic stem cells, into functional pancreatic beta cells. The disclosure provides the benefit of direct differentiation, which results in the production of functional pancreatic beta cells efficiently and at low cost.
    Type: Grant
    Filed: July 26, 2016
    Date of Patent: May 17, 2022
    Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, The J. David Gladstone Institutes, a testamentary trust established under the Will of J. David Gladstone
    Inventors: Matthias Hebrok, Holger Andreas Russ, Sheng Ding, Saiyong Zhu
  • Production of fully functional mature beta cells from human pancreatic progenitors
    Patent number: 11299711
    Abstract: Methods are provided for the simple, fast, effective and safe directed differentiation of embryonic stem cells into the mature beta cells of enriched beta clusters, wherein the beta cells rapidly and reliably secrete insulin in response to glucose levels. The cells are useful transplant therapeutics for diabetic individuals. These cells can also be used for drug screening purposes to identify factors/chemicals capable of increasing beta cell functions, proliferation, survival, and resistance to immune assault.
    Type: Grant
    Filed: April 7, 2017
    Date of Patent: April 12, 2022
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Matthias Hebrok, Holger Andreas Russ, Gopika G. Nair
  • Controlled induction of human pancreatic progenitors produces functional beta-like cells
    Patent number: 10975355
    Abstract: Methods are provided for the simple, fast, effective and safe directed differentiation of embryonic stem cells into pancreatic beta-like cells secreting insulin in response to glucose levels. The cells are useful transplant therapeutics for diabetic individuals.
    Type: Grant
    Filed: April 22, 2016
    Date of Patent: April 13, 2021
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Matthias Hebrok, Holger Andreas Russ
  • PRODUCTION OF FULLY FUNCTIONAL MATURE BETA CELLS FROM HUMAN PANCREATIC PROGENITORS
    Publication number: 20190177697
    Abstract: Methods are provided for the simple, fast, effective and safe directed differentiation of embryonic stem cells into the mature beta cells of enriched beta clusters, wherein the beta cells rapidly and reliably secrete insulin in response to glucose levels. The cells are useful transplant therapeutics for diabetic individuals. These cells can also be used for drug screening purposes to identify factors/chemicals capable of increasing beta cell functions, proliferation, survival, and resistance to immune assault.
    Type: Application
    Filed: April 7, 2017
    Publication date: June 13, 2019
    Inventors: Matthias Hebrok, Holger Andreas Russ, Gopika G. Nair
  • Methods and Compositions for Producing Pancreatic Beta Cells
    Publication number: 20180216076
    Abstract: Compositions and methods of producing mammalian cell populations that include a high proportion of pancreatic beta cells are described herein. Such cell populations are useful for treatment of diabetes. Also provided are materials and methods for the direct differentiation of stem cells, such as embryonic stem cells, into functional pancreatic beta cells. The disclosure provides the benefit of direct differentiation, which results in the production of functional pancreatic beta cells efficiently and at low cost.
    Type: Application
    Filed: July 26, 2016
    Publication date: August 2, 2018
    Inventors: Matthias Hebrok, Holger Andreas Russ, Sheng Ding, Saiyong Zhu
  • Controlled Induction of Human Pancreatic Progenitors Produces Functional Beta-Like Cells
    Publication number: 20180087034
    Abstract: Methods are provided for the simple, fast, effective and safe directed differentiation of embryonic stem cells into pancreatic beta-like cells secreting insulin in response to glucose levels. The cells are useful transplant therapeutics for diabetic individuals.
    Type: Application
    Filed: April 22, 2016
    Publication date: March 29, 2018
    Inventors: Matthias Hebrok, Holger Andreas Russ
  • Generation of thymic epithelial progenitor cells in vitro
    Patent number: 9850465
    Abstract: Methods for generating thymic epithelial progenitor (TEP) cells from pluripotent stem (PS) cells in vitro are provided. Compositions and systems of cell populations of TEP cells as well as cells formed during different stages of differentiation of PS cells into TEP cells are also disclosed. The methods, isolated in vitro cell populations, compositions, and systems disclosed provide functional TEP cells that mature into thymic epithelial cells in vivo.
    Type: Grant
    Filed: February 26, 2014
    Date of Patent: December 26, 2017
    Assignee: The Regents of the University of California
    Inventors: Audrey Parent, Matthias Hebrok, Mark Stuart Anderson
  • Generation of Thymic Epithelial Progenitor Cells In Vitro
    Publication number: 20160010055
    Abstract: Methods for generating thymic epithelial progenitor (TEP) cells from pluripotent stem (PS) cells in vitro are provided. Compositions and systems of cell populations of TEP cells as well as cells formed during different stages of differentiation of PS cells into TEP cells are also disclosed. The methods, isolated in vitro cell populations, compositions, and systems disclosed provide functional TEP cells that mature into thymic epithelial cells in vivo.
    Type: Application
    Filed: February 26, 2014
    Publication date: January 14, 2016
    Inventors: Audrey Parent, Matthias Hebrok, Mark Stuart Anderson
  • Inhibition of pancretic cancer cell growth
    Publication number: 20090012018
    Abstract: The present invention relates to compositions and methods for inhibition of signal transduction pathways in cancer cells. In particular, the present invention provides methods and compositions comprising Wnt and Hedgehog pathway inhibitors for reducing proliferation of adenocarcinoma cells.
    Type: Application
    Filed: September 13, 2005
    Publication date: January 8, 2009
    Inventors: Matthias Hebrok, Marina Pasca Di Magliano